TUDCA (tauroursodeoxycholic acid) is a water-soluble bile acid that has gained significant attention for its liver-protective properties. Originally used in traditional Chinese medicine, TUDCA supports bile flow, protects liver cells from toxin damage, and may improve hepatic insulin sensitivity. It’s become a go-to supplement for liver health, gallbladder support, and increasingly for neuroprotective benefits.
Quick Comparison
Product
TUDCA Per Serving
Form
Best For
Rating
Double Wood TUDCA
500mg
Capsules
Best Overall
4.6/5
Nutricost TUDCA 500mg
500mg
Capsules
Best Value
4.5/5
Dr. Berg TUDCA
250mg
Capsules
Best Trusted Brand
4.5/5
Honeylitte TUDCA 1200mg
1200mg
Capsules
Most Potent
4.4/5
Best Naturals TUDCA
250mg
Capsules
Best Budget Pick
4.4/5
BulkSupplements TUDCA
500mg
Powder
Best Powder
4.3/5
LimerenxLush TUDCA Drops
1500mg
Liquid Drops
Best Liquid
4.3/5
1. Double Wood TUDCA – Best Overall
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TUDCA Bile Salts Liver Support Supplement, 500mg Servings, Liver and Gallbladder Cleanse Supplement (60 Capsules, 250mg) Genuine Bile Acid TUDCA with Strong Bitter Taste by Double Wood
BILE SALT FOR LIVER HEALTH: TUDCA supports healthy levels of liver enzymes
BECOME YOUR BEST SELF: TUDCA helps support your overall health so you feel and operate at your best
MOST POWERFUL BILE SALT FOR LIVER AND GALLBLADDER HEALTH: Studies show TUDCA may help optimize the content of gallbladder bile
OTHER HEALTH BENEFITS: TUDCA is most known for liver health but also supports intestinal, immune, gallbladder, and thyroid healthManufactured in the USA from Globally Sourced Ingredients: Double Wood’s TUDCA pills are manufactured and tested for microbes / heavy metals right here in the USA from Globally Sourced Ingredients
WE BOTTLE WELLNESS: At Double Wood, we provide pure, potent supplements that deliver exceptional value, all backed by careful sourcing and rigorous third-party testing
Double Wood’s TUDCA is the gold standard in this category, trusted by thousands of users for reliable liver and gallbladder support.
Each serving delivers 500mg of TUDCA across two capsules (250mg each), providing a clinically relevant dose for bile flow optimization and liver protection. The formula uses genuine bile acid TUDCA with a characteristic bitter taste that confirms authenticity. Manufactured and third-party tested in the USA, this supplement contains no unnecessary fillers. A 60-capsule bottle provides a full 30-day supply at the recommended dose. For those also interested in comprehensive liver cleanse supplements, TUDCA pairs well with milk thistle.
Pros:
500mg per serving at a competitive price point
Third-party tested in the USA for purity and heavy metals
Genuine bile acid with authentic bitter taste verification
Cons:
Requires two capsules per serving
Bitter taste may be noticeable if capsule is opened
Best for: Anyone seeking a well-established, trusted TUDCA supplement for daily liver and gallbladder support
2. Nutricost TUDCA 500mg – Best Value
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Nutricost Tudca 500mg, 30 Capsules (Tauroursodeoxycholic Acid) – Premium Quality, Gluten Free
30 Capsules of Tudca Per Bottle
500mg of Tudca Per Serving (Serving Size Just 1 Capsule)
Non-GMO, Soy Free, and Gluten Free
Tested by Independent, ISO-Accredited Laboratories
Manufactured in an NSF Certified, GMP Compliant, FDA Registered Facility
Nutricost delivers a full 500mg of TUDCA per capsule at one of the most affordable prices in the category.
This single-capsule formula simplifies dosing while delivering the same potency as competitors requiring two capsules. Nutricost manufactures in an NSF-certified, GMP-compliant, FDA-registered facility and conducts third-party testing on every batch. The TUDCA is not derived from bear bile, using a synthetic process instead. Each bottle contains 30 capsules for a one-month supply. The straightforward, no-frills formula contains TUDCA with minimal inactive ingredients.
Pros:
Full 500mg dose in a single capsule
NSF-certified facility with third-party testing
One of the lowest cost-per-serving options
Cons:
Only 30 servings per bottle
Contains gelatin capsule (not vegan)
Best for: Budget-conscious buyers who want a high-potency, single-capsule TUDCA supplement
3. Dr. Berg TUDCA – Best Trusted Brand
Dr. Berg TUDCA Supplement (Tauroursodeoxycholic Acid) – Powerful Formula for Liver Health, Bile Flow, Gallbladder Support, and Digestive Health* – 30 Capsules
𝗣𝗢𝗪𝗘𝗥𝗙𝗨𝗟 𝗕𝗜𝗟𝗘 𝗦𝗔𝗟𝗧 – Support your liver, gallbladder, and digestive system. Tauroursodeoxycholic acid is a powerful bile salt that promotes optimal bile flow, vital for liver function, gallbladder health, and nutrient absorption.
𝗠𝗘𝗧𝗔𝗕𝗢𝗟𝗜𝗦𝗠 𝗦𝗨𝗣𝗣𝗢𝗥𝗧 – TUDCA also aids bile acid metabolism and promotes metabolic health by protecting the liver from the harmful effects of oxidative stress.
𝗠𝗔𝗫𝗜𝗠𝗨𝗠 𝗘𝗙𝗙𝗘𝗖𝗧𝗜𝗩𝗘𝗡𝗘𝗦𝗦 – In just one capsule, experience a high-potency formula designed for optimal performance and effectiveness.
𝗔𝗗𝗩𝗔𝗡𝗖𝗘𝗗 𝗙𝗢𝗥𝗠𝗨𝗟𝗔 – Recommended by Dr. Berg, this TUDCA supplement delivers 250 mg of TUDCA in each serving for targeted support.
𝗧𝗥𝗬 𝗙𝗢𝗥 𝟯𝟬 𝗗𝗔𝗬𝗦 – If you are unhappy with this product reach out to us within 30 days of your purchase date and we will take care of you.
Dr. Berg’s TUDCA provides a moderate 250mg dose in a formula designed for targeted liver health, bile flow, and gallbladder support.
Each capsule delivers 250mg of TUDCA per serving, which is a solid maintenance dose for daily liver protection. The formula is recommended by Dr. Berg, a well-known health educator, and is designed for maximum effectiveness in a single capsule format. The 30-capsule bottle provides a full month supply. This is a strong option for those who prefer a moderate dose or want to ease into TUDCA supplementation.
Pros:
Backed by a recognized health brand
One capsule per serving for easy dosing
Moderate dose suitable for daily maintenance
Cons:
Lower dose (250mg) compared to competitors
Higher cost per milligram than bulk options
Best for: Those who prefer a trusted brand name and moderate TUDCA dosing for daily maintenance
4. Honeylitte TUDCA 1200mg – Most Potent
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Honeylitte delivers the highest per-serving dose on this list at 1200mg of pure TUDCA for aggressive liver support.
This ultra-strength formula provides 1200mg of pharmaceutical-grade TUDCA per serving across two vegan capsules. The clean-label formula contains no fillers, GMOs, gluten, or gelatin, making it suitable for a wide range of dietary preferences. Produced in a cGMP-certified facility with rigorous third-party testing for identity, purity, and potency. The 90-capsule bottle provides a 45-day supply at the recommended two-capsule daily dose.
Pros:
Highest potency at 1200mg per serving
100% vegan capsules with zero fillers
90 capsules for extended 45-day supply
Cons:
High dose may be unnecessary for maintenance use
Newer brand with limited track record
Best for: Those seeking the highest-potency TUDCA supplement for intensive liver support
5. Best Naturals TUDCA – Best Budget Pick
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Best Naturals TUDCA 250mg (Tauroursodeoxycholic Acid) – 60 Veg Capsules – 2 Months Supply (60 Count (Pack of 1)) (60 Count (Pack of 1))
3rd Party Lab Tested for Purity & Quality.
250 mg of Tudca per Vegetarian Capsule – 60 Capsules per Bottle.
Non-GMO & Gluten-Free.
Proudly Made in USA, GMP Compliant, FDA Registered Facility.
No Artificial Color, Flavor, or Sweetener, No Preservatives, No Sugar, No Milk, No Corn, No Soy, No Egg, No Lactose, No Gluten, No Wheat, No Yeast, No Fish. Sodium Free.
Best Naturals offers a straightforward 250mg TUDCA at an entry-level price point, ideal for those new to the supplement.
Each capsule delivers 250mg of TUDCA in a non-GMO, gluten-free formula. The product is manufactured in a GMP-compliant, FDA-registered facility in the USA. The 60-capsule bottle provides a full two-month supply at one capsule daily, or one month at two capsules daily for a 500mg dose. The clean formula avoids common allergens including milk, corn, soy, egg, lactose, wheat, and yeast.
Pros:
Excellent price for 60 capsules
Free from major allergens
Flexible dosing at 250mg per capsule
Cons:
250mg may require doubling up for therapeutic doses
Less brand recognition than premium options
Best for: First-time TUDCA users or anyone seeking affordable daily liver support
6. Nutricost TUDCA 250mg – Best for Flexible Dosing
Nutricost Tudca 250mg, 60 Capsules (Tauroursodeoxycholic Acid) – Premium Quality
60 Capsules of Tudca In Each Bottle
250mg of Tudca Per Capsule. Just One Capsule Per Serving
High Quality Tudca, Non-GMO, Soy Free, and Gluten Free
3rd Party Tested By ISO-Accredited Laboratories
Manufactured in an NSF Certified, GMP Compliant, FDA Registered Facility. Lid May be White or Blue
Nutricost’s lower-dose TUDCA option provides 250mg per capsule, allowing precise dose customization for different health goals.
This 60-capsule bottle at the 250mg strength allows users to take one capsule for maintenance support or two for a full 500mg therapeutic dose. Like its higher-dose sibling, it’s manufactured in an NSF-certified, GMP-compliant facility with independent third-party testing. The TUDCA is synthetically produced rather than derived from animal bile, appealing to those concerned about sourcing. If you’re also supporting liver health with NAC supplements, TUDCA makes an excellent complementary addition.
Pros:
Flexible dosing from 250mg to 500mg daily
60-capsule bottle stretches up to two months
Same quality standards as premium Nutricost products
Cons:
Requires two capsules for standard 500mg dose
Contains gelatin capsule
Best for: Those who want flexible dose control to dial in the right TUDCA amount for their needs
7. BulkSupplements TUDCA Powder – Best Powder
BulkSupplements.com TUDCA Powder – Tauroursodeoxycholic Acid, TUDCA 500mg – TUDCA Supplement for Liver Support – Gluten Free, 500mg per Serving, 50g (1.8 oz) (Pack of 1)
Elevate Your General Health and Well-being: Tailored to support your overall health, our TUDCA 500mg powder, or TUDCA Liver Support supplement, is the perfect addition to any lifestyle. Packed with essential nutrients, they’re designed to boost your general well-being, keeping you feeling your best day after day.
Tailored for Modern Lifestyles: Our TUDCA supplement is not just about nutrition; Tauroursodeoxycholic Acid powder is about fitting into your modern lifestyle with ease. Whether you are a just starting a healthier living, or a health-conscious professional, our products are crafted to complement your dietary preferences and wellness goals.
Convenient Powder Form for Easy Integration: Say goodbye to cumbersome pill regimes! Our TUDCA supplement, in TUDCA 500mg, come in a versatile powder form, making it incredibly easy to integrate into any lifestyle. Just add it to your morning smoothie, juice or plain water can elevate your daily nutritional intake without any hassle.
Transparent and Trustworthy: Experience the confidence that comes with choosing a supplement that not only meets rigorous third party testing but also upholds the principles of clarity and integrity in its formulation and production.
Commitment to Excellence: Produced in a facility compliant with strict cGMP standards, our TUDCA powder, in TUDCA 500mg, stands as a testament to our dedication to quality. You can trust in our product’s consistency and excellence, batch after batch.
BulkSupplements offers TUDCA in pure powder form for maximum dosing flexibility and cost efficiency.
The 50g pouch provides approximately 100 servings at the recommended 500mg per dose, making it one of the most cost-effective TUDCA options available. Produced in a cGMP-compliant facility, the powder is lab-tested for quality and purity. The powder form allows for precise customization of dose amounts and can be mixed into liquids or encapsulated at home. Note that a milligram scale is recommended for accurate dosing.
Pros:
Lowest cost per serving in the TUDCA market
Complete dosing flexibility
Approximately 100 servings per pouch
Cons:
Requires a milligram scale for accurate dosing
Strong bitter taste in powder form
Best for: Experienced supplement users who want bulk TUDCA at the lowest possible cost
8. LimerenxLush TUDCA Drops 1800mg – Best Liquid
LimerenxLush TUDCA Liver Support Drops 1800mg – Powerful Liver Supplement with Bile Salts, NAC, Schisandra and Dandelion, Liver Detox & Repair – Fast-Absorbing, Sugar-Free, Alcohol-Free – 2 Fl.Oz
Maximum Potency for Liver Support: Each serving provides 1500 mg of TUDCA to support liver function and overall wellness. It also helps maintain healthy bile processes as part of a strong daily liver support routine
HepatoDefense Complex for Synergistic Support: Our unique TUDCA supplement formula includes N-Acetyl Cysteine, Schisandra Berry Extract, and Dandelion Root Extract, working together to support natural liver processes and help maintain overall liver wellness
Fast-Absorbing Liquid Drops Formula:Our TUDCA bile salts supplement provides faster and more efficient absorption than tablets or capsules, making it an ideal option for those with digestive challenges or difficulty swallowing pills
Diet-Friendly and Clean:Our TUDCA supplement is crafted without alcohol, sugar, animal products, soy, gluten, dairy, or GMOs—suitable for various dietary preferences, including vegan diets.It’s ideal for everyday liver support with a clean, simple formula
Premium Liver Support Supplement: Proudly made in the USA, our TUDCA liver support supplements with bile salts are carefully formulated to ensure high potency and quality
LimerenxLush delivers TUDCA in a fast-absorbing liquid drop format with synergistic liver support ingredients including NAC, Schisandra, and Dandelion Root.
Each serving provides 1500mg of TUDCA in a sugar-free, alcohol-free liquid formula that absorbs faster than traditional capsules. The HepatoDefense Complex adds N-Acetyl Cysteine (NAC), Schisandra Berry Extract, and Dandelion Root Extract for comprehensive liver protection. The 2 fl oz bottle is diet-friendly—vegan, soy-free, gluten-free, and dairy-free. This is an ideal choice for those who have difficulty swallowing pills or want faster absorption. For additional detox support, consider pairing with a full liver cleanse protocol.
Pros:
Liquid format for faster absorption
Multi-ingredient formula with NAC and herbal extracts
No pills to swallow
Cons:
Shorter supply compared to capsule bottles
More expensive per serving than capsule options
Best for: Those who prefer liquid supplements or want a comprehensive liver support formula beyond TUDCA alone
How to Choose the Best TUDCA Supplement
When selecting a TUDCA supplement, dosage is the most important factor. Clinical studies have used doses ranging from 250mg to 1,750mg daily, with 500mg being the most common dose for general liver support. Start at 250mg daily and increase as needed based on your health goals and practitioner guidance.
Look for third-party tested products manufactured in cGMP-certified facilities. TUDCA should be synthetically produced rather than derived from bear bile, which is both an ethical and quality concern. Genuine TUDCA has a characteristic bitter taste—if a product claims to be TUDCA but has no bitterness, it may be low-quality or underdosed.
Capsules are the most popular delivery form, though powder offers the best cost-per-serving and liquids provide faster absorption. Choose the form that best fits your routine and comfort level. Most users take TUDCA with meals, as it supports bile production that aids fat digestion.
For maximum liver support, TUDCA stacks well with other liver-protective compounds like NAC, milk thistle, and artichoke extract. Check for clean labels free from unnecessary fillers, artificial ingredients, and common allergens.
Frequently Asked Questions
What is TUDCA and what does it do?
TUDCA (tauroursodeoxycholic acid) is a water-soluble bile acid naturally produced in small amounts by the body. It supports liver cell health by reducing endoplasmic reticulum stress, promotes healthy bile flow, protects against liver cell death, and may improve insulin sensitivity. It has been used in clinical settings for liver and gallbladder conditions and is now widely available as a dietary supplement.
How much TUDCA should I take daily?
Most supplements provide 250-500mg per serving, with 500mg daily being the most commonly studied dose for general liver support. Clinical studies have used doses up to 1,750mg daily for specific conditions. Start with a lower dose (250mg) and increase gradually. Always follow the manufacturer’s recommendations and consult a healthcare provider for personalized dosing.
When is the best time to take TUDCA?
TUDCA is best taken with meals, particularly meals containing fat, as it supports bile production needed for fat digestion. Taking it with food also reduces the chance of stomach discomfort. Some users split their dose between morning and evening meals for sustained support throughout the day.
Are there any side effects of TUDCA?
TUDCA is generally well tolerated at recommended doses. Some users report mild digestive discomfort, diarrhea, or nausea when first starting. These effects typically diminish within a few days. TUDCA is a bile acid, so those with bile duct obstruction or certain gallbladder conditions should consult a physician before use.
Can I take TUDCA with other supplements?
TUDCA stacks well with other liver support supplements including NAC, milk thistle, artichoke extract, and dandelion root. It’s commonly used alongside vitamin D and omega-3 fatty acids. Those taking prescription medications should consult a healthcare provider, as TUDCA may affect the absorption of certain drugs through its effects on bile acid metabolism.
How long does it take for TUDCA to work?
Many users report noticing improved digestion and reduced bloating within 1-2 weeks of consistent use. Liver enzyme improvements may be measurable through blood work within 4-8 weeks. For neuroprotective or more systemic benefits, longer-term use of 2-3 months is typically recommended before assessing results.