Palmitoylethanolamide (PEA) is a naturally occurring fatty acid amide produced by the body to help regulate pain signaling, inflammation, and immune responses. Discovered in the 1950s, PEA has been the subject of over 600 clinical studies demonstrating its ability to support nerve comfort, joint health, and balanced inflammatory responses without the side effects associated with NSAIDs.
As interest in natural pain management grows, PEA supplements — particularly micronized and liposomal forms with enhanced bioavailability — have become one of the fastest-growing categories in the supplement market. PEA works through the endocannabinoid system by modulating PPAR-alpha receptors and enhancing the activity of the body’s own endocannabinoids, providing meaningful comfort support without the risks of dependency, tolerance, or cognitive impairment associated with many conventional pain management options.
Quick Comparison
Product
PEA Dose
Form
Best For
Rating
Neurogan Ultra Micronized PEA
1,500mg
Capsules
Best Overall
9.5/10
X Gold Health Micronized PEA
600mg
Capsules
Best Value
9.3/10
Natgrown PEA 600mg
600mg
Capsules
Best Budget Pick
9.1/10
Gade Nutrition PEA + Quercetin
800mg
Capsules
Best Multi-Ingredient
9.0/10
Ulmubra Liposomal PEA + Luteolin
1,300mg
Softgels
Best Liposomal Formula
9.0/10
Rosmolo Liposomal PEA + Luteolin
1,000mg
Softgels
Best for Nerve Support
8.8/10
HARVEST NATURALS PEA 400mg
400mg
Capsules
Best Low-Dose Starter
8.7/10
1. Neurogan Ultra Micronized PEA 1500mg – Best Overall
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Neurogan Ultra Micronized Palmitoylethanolamide (Pea) Supplement – 1500 MG Per Serving – Highly Purified & Bioavailable – 90 Capsules – Natural Support for Men & Women
ENHANCED ABSORPTION: Our PEA Pro Capsules undergo ultra-micronization process for maximum absorption.
BALANCED LIFESTYLE: Palmitoylethanolamide, supports the body’s natural equilibrium, especially in response to stress. It’s ideal for those seeking a comfortable lifestyle and a natural choice for balanced wellness.
PURE AND POTENT FORMULA: Our PEA Palmitoylethanolamide supplement are free of fillers, ensuring utmost purity and potency. Trust only in the highest-quality ingredients for your health and well-being journey.
A FAMILY-OWNED LEGACY: Neurogan is more than just a brand—it’s a family-owned legacy driven by passion and dedication. Proudly made in the USA, our supplements undergo meticulous crafting in a GMP-certified facility, backed by third-party lab tests for unmatched quality and safety.
TRUSTED BRAND: As a family-owned brand based in California, USA, we stand firmly behind the quality of our products.
Neurogan delivers the highest PEA dose on the market at 1,500mg per serving in an ultra-micronized format, maximizing both potency and absorption for serious pain and inflammation support.
Ultra-micronization reduces PEA particle size dramatically, addressing one of the compound’s key challenges: poor water solubility and absorption in standard form. Neurogan’s ultra-micronized PEA achieves significantly better bioavailability than regular PEA powder, meaning more of the active compound reaches your system. The 1,500mg dose per serving is at the high end of clinically studied ranges, making it suitable for those with more significant comfort needs. The capsules are vegan, non-GMO, and manufactured in a GMP-certified US facility. For those also dealing with joint discomfort, combining PEA with a dedicated joint pain supplement can address both nerve and structural sources of discomfort.
Pros:
Highest PEA dose available (1,500mg per serving)
Ultra-micronized for dramatically improved bioavailability
Vegan, non-GMO, GMP-certified US manufacturing
Cons:
Premium pricing reflects the high dose and micronized processing
May require 2-3 capsules per serving to reach 1,500mg
Best for: Those who need maximum-strength PEA support for significant nerve discomfort, chronic pain conditions, or inflammatory issues
2. X Gold Health Micronized PEA 600mg – Best Value
Palmitoylethanolamide Pea Supplement 600 mg | Micronized Pea 99% Highly Purified and Bioavailable | Made in USA | Supplement for Men and Women – 120 Capsules
NATURAL DISCOMFORT RELIEF: The Best Quality Micronized Palmitoylethanolamide PEA Supplement, our 600 mg micronized Palmitoylethanolamide Specially formulated to relieve and reduce general discomfort quickly;
MICRONIZED PEA FOR HIGH AVAILABILITY: Studies for micronized palmitoylethanolamide PEA have shown that when taken daily MICRONIZED PEA significantly increased comfort levels in addition to having more efficient absorption than Regular PEA. Micronized for increased availability and efficiency, our capsules contain a high dose of 99% PEA for an incredibly effective combination against discomfort;
CLINICALLY STUDIED FORMULA: .Studies for Palmitoylethanolamide (PEA) have shown that when taken every day for a few weeks, PEA significantly supported comfort levels for participants. X Gold Health Micronized PEA formula contains 600 mg per serving same as the clinical study.
FOR MEN & WOMEN PEA is a powerful and natural antioxidant agent that may relieve discomfort and strengthen the immune system. Supporting your body’s discomfort management system with naturally occurring PEA (palmitoylethanolamide), a fatty acid that plays a central role in the fight against discomfort and helps you run at peak capacity.
THE BEST AROUND: With purer ingredients sourced from around the world and manufactured and tested for quality in the USA, our non-GMO, vegetarian capsules are free of gluten, soy, eggs, dairy, nuts, and harmful preservatives to be inclusive so everyone can feel the tremendous benefits of this high-quality complex.
X Gold Health offers 99% pure micronized PEA at the clinically validated 600mg dose per capsule, delivering research-grade quality at an accessible price point.
Each capsule provides 600mg of micronized PEA — the exact dose used in numerous clinical trials demonstrating benefits for nerve comfort, inflammatory balance, and immune modulation. The 99% purity specification ensures minimal filler and maximum active compound per capsule. The formula is manufactured in the USA, free from GMOs, gluten, soy, and artificial additives. The 120-capsule bottle provides a generous supply that can last 2-4 months depending on dosing, making it one of the best values in the micronized PEA category.
Pros:
99% pure micronized PEA at the standard clinical dose
Excellent price per serving, especially at 120-count
Clean formula with no unnecessary fillers or additives
Cons:
Single-ingredient formula (no synergistic compounds like luteolin)
600mg may be insufficient for those with more severe symptoms (can take two capsules)
Best for: Those seeking a well-priced, research-backed PEA supplement at the standard clinical dose
3. Natgrown PEA 600mg – Best Budget Pick
Natgrown Palmitoylethanolamide Pea Supplement 600 mg – 120 Capsules
The Best Quality Palmitoylethanolamide PEA Supplement – 600 mg Palmitoylethanolamide pills deliver a pure, potent dose for occasional minor pain and discomfort
NATURAL DISCOMFORT RELIEF – Studies have shown that when taken every day for three weeks, Palmitoylethanolamide (PEA) can support comfort levels. Our formula contains 600 mg per serving, mirroring the clinical study dosage
For Men & Women – PEA (Palmitoylethanolamide) is a compound naturally produced by your body. Our supplement contains 600 mg per serving so that you can live comfortably
Suggested Use – As a dietary supplement, take two capsules once a day with a full glass of water. Best when taken as directed by a qualified healthcare professional
MADE IN THE USA – Made with Palmitoylethanolamide (PEA). Our products do not contain gluten, milk, soy, tree nuts, peanuts, or wheat
Natgrown provides a straightforward 600mg PEA formula at one of the lowest price points in the category, making PEA supplementation accessible to budget-conscious buyers.
Each capsule delivers 600mg of palmitoylethanolamide in a clean, minimal formula. Natgrown focuses on simplicity and affordability, providing the clinically studied dose without premium pricing for branded ingredients or advanced delivery systems. The capsules are suitable for daily use and manufactured following GMP standards. For those new to PEA supplementation, starting at 600mg daily provides a solid foundation to evaluate the compound’s effects on comfort and inflammation before considering higher doses.
Pros:
Among the most affordable PEA supplements available
Standard 600mg clinical dose per capsule
Simple, no-frills formula with minimal excipients
Cons:
Not micronized, which may reduce absorption compared to processed forms
Less established brand compared to premium PEA companies
Best for: Budget-conscious buyers who want to try PEA at the clinical dose without a significant upfront investment
4. Gade Nutrition PEA 800mg + Quercetin – Best Multi-Ingredient
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Gade Nutrition Palmitoylethanolamide Pea Supplement 800 mg with Quercetin 200 mg | Micronized Pea 99% Highly Purified and 95% Quercetin Bioavailable | Made in USA | Supplement for Men and Women
ADVANCED PEA SUPPLEMENT: Palmitoylethanolamide (PEA) is a naturally occurring fatty acid amide that plays a crucial role in maintaining a balanced inflammatory response. Our palmitoylethanolamide supplement contains micronized PEA (99% pure) for superior bioavailability, ensuring your body absorbs and utilizes it efficiently. This powerful compound supports nerve comfort, joint health, and immune regulation, making it an essential part of your wellness routine. Combined with quercetin phytosome, it enhances cellular health and immune function, providing comprehensive immune support and relief from occasional discomfort.
STRENGTHEN YOUR IMMUNE SYSTEM WITH QUERCETIN PHYTOSOME: Quercetin is a potent flavonoid known for its ability to stabilize immune responses and support antioxidant activity. Our formula uses quercetin phytosome, a cutting-edge absorption technology that binds quercetin to phospholipids, ensuring superior uptake and bioavailability. As a leading immune support supplement, it works in synergy with PEA to regulate immune function, promote respiratory health, and defend against environmental stressors. With 200 mg of highly bioavailable quercetin phytosome, this formula delivers targeted support for daily immune resilience.
NERVE COMFORT: PEA is widely studied for its ability to support nerve health, making it an effective solution for individuals seeking natural relief. Palmitoylethanolamide helps modulate the body’ signals, reducing discomforts. When combined with quercetin, it provides additional antioxidant benefits that protect nerve health. This dual-action approach makes our PEA supplement ideal for those looking to support long-term health.
CLEAN, HIGH-QUALITY FORMULA FOR MAXIMUM BENEFITS: We are committed to delivering a palmitoylethanolamide supplement that meets the highest quality standards. Our formula is free from GMOs, gluten, soy, and artificial additives, making it a clean and natural choice for those seeking effective immune boosters for adults. Designed for maximum absorption and effectiveness, our PEA with Quercetin supplement is carefully crafted to support your body’s natural defense systems and overall well-being. Whether you need enhanced immune function, joint support, or nerve relief, this immunity supplement is the perfect addition to your daily regimen.
SAFE STANDARD QUALITY: Our products are manufactured in the USA with all-natural, fast-dissolving veggie capsules. Made in an FDA-registered laboratory that is GMP certified. We hold ourselves to high standards of 100% natural purity, Potency, and Third Party Tested. Trust Gade Nutrition for a high-quality supplement. Our pills are made with non-GMO, gluten-free, sugar-free ingredients, no stimulants, no binders, no fillers, no allergens, and no chemicals
Gade Nutrition combines 800mg of 99% pure micronized PEA with 200mg of quercetin phytosome for a dual-action formula that addresses both inflammatory balance and antioxidant support.
This formula stands out by pairing PEA’s endocannabinoid-modulating effects with quercetin phytosome — an advanced absorption form that binds quercetin to phospholipids for superior uptake compared to standard quercetin. The combination targets nerve comfort, joint health, and immune regulation from multiple pathways. PEA modulates the body’s pain and inflammatory signals while quercetin provides potent antioxidant protection and additional immune-stabilizing effects. The product is free from GMOs, gluten, soy, and artificial additives, and is made in the USA. For broader anti-inflammatory support, PEA with quercetin creates a strong foundation that can be enhanced with omega-3s or curcumin.
Pros:
Synergistic PEA + quercetin phytosome combination
99% pure micronized PEA for enhanced bioavailability
Quercetin phytosome provides superior absorption over standard quercetin
Cons:
Higher cost than single-ingredient PEA supplements
Newer brand with limited long-term track record
Best for: Those who want a comprehensive anti-inflammatory and immune-modulating formula that combines PEA with enhanced-absorption quercetin
5. Ulmubra Liposomal PEA 1300mg + Luteolin – Best Liposomal Formula
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Ulmubra uses liposomal delivery technology to encapsulate 1,300mg of micronized PEA plus 100mg of luteolin in phospholipid spheres, dramatically improving absorption and cellular delivery.
Liposomal formulations wrap active ingredients in tiny fat-based vesicles that protect them through the digestive system and enhance absorption into cells. This addresses PEA’s inherent challenge of poor water solubility by creating a lipid-compatible delivery system. The addition of luteolin — a flavonoid with potent mast cell stabilizing and neuroprotective properties — creates a synergistic pairing frequently recommended in integrative medicine protocols for neuroinflammation and chronic pain conditions. The softgel format provides convenient dosing and stable shelf life.
Pros:
Liposomal technology significantly enhances PEA absorption
Synergistic PEA + luteolin combination used in clinical protocols
High 1,300mg dose in a convenient softgel format
Cons:
Premium pricing for liposomal delivery technology
Softgels contain gelatin (not suitable for vegans)
Best for: Those who want maximum absorption through advanced delivery technology, especially for neuroinflammation and chronic pain protocols
6. Rosmolo Liposomal PEA 1000mg + Luteolin – Best for Nerve Support
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Rosmolo combines 1,000mg of liposomal PEA with luteolin in a targeted formula specifically designed for nerve comfort and neuroprotective support.
The PEA + luteolin combination has been extensively studied for its effects on nerve health, with PEA modulating endocannabinoid signaling pathways that regulate pain perception while luteolin provides neuroprotective antioxidant activity. Rosmolo’s liposomal delivery ensures both compounds reach target tissues efficiently. The 1,000mg PEA dose sits in the effective mid-range between the standard 600mg clinical dose and higher 1,500mg options, providing strong nerve support without excessive dosing. For those dealing with nerve-related discomfort, combining PEA with a turmeric supplement can provide additional anti-inflammatory coverage.
Pros:
Targeted PEA + luteolin formula with strong research support for nerve health
Liposomal delivery for enhanced bioavailability
Well-balanced 1,000mg dose in the effective clinical range
Cons:
Softgel format may not suit those who prefer capsules
Higher cost per serving than standard PEA capsules
Best for: Those specifically seeking nerve comfort and neuroprotective support, particularly for conditions involving peripheral nerve discomfort
7. HARVEST NATURALS PEA 400mg – Best Low-Dose Starter
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HARVEST NATURALS offers PEA at a conservative 400mg dose per capsule, making it ideal for those who want to start at a lower dose and titrate up based on individual response.
Not everyone needs — or tolerates — high-dose PEA supplementation from the start. HARVEST NATURALS’ 400mg formula allows users to begin conservatively and adjust their intake by adding capsules as needed. This approach is particularly useful for those with sensitivities or those who are new to endocannabinoid-modulating supplements. The formula uses clean ingredients without artificial fillers or common allergens, and is manufactured in the USA under GMP standards.
Pros:
Flexible low-dose option for gradual titration
Clean formula suitable for those with sensitivities
Easy to customize dosing by adjusting capsule count
Cons:
May require multiple capsules to reach effective clinical doses (600-1,200mg)
Not micronized, which may limit absorption
Best for: First-time PEA users, those with supplement sensitivities, or anyone who prefers starting at a low dose and gradually increasing
How to Choose the Best PEA Supplement
The most critical factor in PEA supplementation is the form of PEA used. Standard (non-micronized) PEA has poor water solubility and limited bioavailability, meaning much of it passes through the digestive system unabsorbed. Micronized PEA reduces particle size significantly (typically below 10 micrometers), improving absorption and effectiveness by increasing the surface area available for uptake. Liposomal PEA goes further by encapsulating the compound in phospholipid vesicles for enhanced cellular delivery. If budget allows, always choose micronized or liposomal forms over standard PEA powder — the difference in bioavailability can mean the difference between noticeable results and minimal effect.
The clinically studied dose range for PEA is 300-1,200mg daily, with 600mg being the most commonly used dose in clinical trials for conditions ranging from sciatic pain to carpal tunnel syndrome to chronic low back pain. For general wellness and mild discomfort, 600mg daily is a good starting point. Those with more significant pain or inflammatory conditions may benefit from 1,000-1,500mg daily, often split into two doses (morning and evening). Start at the lower end and increase gradually over 2-4 weeks to find your optimal dose. Many practitioners recommend a “loading phase” of higher doses (1,200mg) for the first 4-6 weeks, then reducing to a maintenance dose of 600mg.
Consider whether a standalone PEA product or a combination formula best suits your needs. PEA pairs synergistically with luteolin (for neuroprotective benefits and enhanced mast cell stabilization) and quercetin (for immune and antioxidant support). The PEA + luteolin combination is particularly well-studied in neuroinflammation and chronic pain protocols, as luteolin inhibits the release of pro-inflammatory mediators from mast cells and microglia, amplifying PEA’s anti-inflammatory effects. These combinations are commonly used in integrative medicine protocols for chronic pain, neuroinflammation, and immune modulation.
Look for products with 99% purity specifications, GMP certification, and transparent labeling of both active and inactive ingredients. PEA is classified as a food supplement rather than a pharmaceutical in most countries, so quality varies significantly between manufacturers. Reputable brands will specify whether their PEA is micronized, ultra-micronized, or liposomal, and will clearly state the purity level on the label. Avoid products that list PEA as part of a proprietary blend without disclosing the exact dose, as underdosing is common in multi-ingredient formulas.
Frequently Asked Questions
What is palmitoylethanolamide (PEA) and what does it do?
PEA is a fatty acid amide that your body naturally produces as part of the endocannabinoid system. It acts on peroxisome proliferator-activated receptor alpha (PPAR-α) and other targets to modulate pain signaling, reduce inflammatory responses, and support immune balance. Unlike CBD, which directly binds cannabinoid receptors, PEA works through an “entourage effect” by enhancing the activity of the body’s own endocannabinoids like anandamide. This mechanism supports nerve comfort, joint health, and balanced immune function without psychoactive effects. PEA was first identified in egg yolk and soy lecithin in the 1950s, and Nobel laureate Rita Levi-Montalcini’s research helped establish its role in controlling cellular inflammation and immune responses.
How much PEA should I take daily?
Clinical trials have used doses ranging from 300mg to 1,200mg daily, with 600mg being the most common effective dose across studies. For general wellness and mild discomfort, 600mg daily is effective. For more significant pain or inflammatory conditions, 1,000-1,200mg daily (often split into two doses of 600mg morning and evening) may be more appropriate. Start at 600mg and increase gradually every 1-2 weeks based on your response. Micronized and liposomal forms may be effective at lower doses due to improved absorption. Many practitioners recommend a higher “loading dose” period of 1,200mg daily for the first month, then reducing to 600mg for ongoing maintenance.
When is the best time to take PEA?
PEA can be taken at any time of day and is well-absorbed with or without food. Many practitioners recommend taking it with meals for optimal absorption, as PEA is a fatty acid amide that may benefit from the presence of dietary fats. For those taking divided doses (e.g., 600mg twice daily), morning and evening dosing provides more consistent levels throughout the day. PEA does not cause drowsiness or stimulation, so timing is primarily based on convenience.
Are there any side effects of PEA?
PEA has an excellent safety profile across over 600 clinical studies, with very few reported side effects. Mild digestive effects (occasional stomach upset) have been noted in some individuals, particularly at higher doses. PEA does not cause dependence, tolerance, or withdrawal effects, and it does not interact with the opioid system. It has no known significant drug interactions, though as with any supplement, inform your healthcare provider about all supplements you’re taking.
Can PEA replace NSAIDs or pain medication?
PEA works through entirely different mechanisms than NSAIDs and should not be viewed as a direct replacement without medical guidance. While clinical studies show PEA can meaningfully reduce discomfort scores across various pain types, it works gradually through anti-inflammatory modulation rather than acute pain blocking. Some people successfully reduce their NSAID use after establishing PEA supplementation, but any changes to pain medication should be discussed with a healthcare provider. PEA is most commonly used as a complementary approach alongside conventional pain management.
How long does it take for PEA to work?
Most clinical trials show noticeable benefits within 2-4 weeks of consistent daily use, with optimal effects developing over 6-8 weeks. Some users report improvements within the first week, particularly with micronized or liposomal forms that achieve higher blood levels faster. PEA works by gradually modulating inflammatory pathways and enhancing endocannabinoid tone, so consistent daily use is more important than taking it only when symptoms flare. Benefits tend to increase progressively over the first 2-3 months of use.
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