Nattokinase is a fibrinolytic enzyme derived from natto, a traditional Japanese fermented soybean dish that has been consumed for over a thousand years. It has gained widespread interest for its ability to break down fibrin (a protein involved in blood clotting), support healthy circulation, and promote cardiovascular wellness. Nattokinase potency is measured in fibrinolytic units (FU), with most effective supplements delivering 2,000-10,000 FU per serving. Unlike pharmaceutical blood thinners, nattokinase works through a natural enzymatic process and has been the subject of numerous clinical studies examining its effects on blood flow, blood pressure, and cardiovascular markers.
Quick Comparison
Product
Potency
Form
Best For
Rating
Lunakai Nattokinase 8000 FU
8,000 FU
Capsules
Best Overall
4.6/5
Luma Nutrition Nattokinase 4000 FU
4,000 FU
Capsules
Best Value
4.5/5
Double Wood Nattokinase 4000 FU
4,000 FU
Capsules
Best Seller
4.5/5
Doctor’s Best Nattokinase 2000 FU
2,000 FU
Veg Caps
Best Trusted Brand
4.6/5
Toku Nattokinase 10,800 FU
10,800 FU
Capsules
Most Potent
4.5/5
Horbäach Nattokinase 4000 FU
4,000 FU
Capsules
Best Budget Pick
4.5/5
Pure Encapsulations NSK-SD Nattokinase
2,000 FU
Capsules
Best Premium
4.7/5
1. Lunakai Nattokinase Supplement 8000 FU – Best Overall
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Lunakai USA Made Nattokinase Supplement – 400mg Natto Enzyme, 8000 FU per Serving – Heart & Circulation Support – Non-GMO, 60ct, 4000 FU Capsule
Supports Circulation – Each serving delivers 8000 FU of nattokinase, traditionally sourced to assist in supporting normal blood flow.
Natural Heart Support – Our nattokinase supplement is formulated to complement daily routines focused on overall heart wellness support.
Clean & Simple Ingredients – Each capsule contains 200mg of nattokinase enzyme, delivering 4000 FU, sourced from fermented natto with no artificial flavors or additives.
Vegan-Friendly Formula – Our nattokinase supplement is 100% vegan and plant-based, with no animal-derived ingredients or gelatin.
Made in the USA – Manufactured in the United States in a facility that follows GMP (Good Manufacturing Practices) for quality and consistency.
Lunakai delivers an impressive 8,000 FU of nattokinase per serving, making it one of the most potent single-serving options available while maintaining clean, USA-made quality standards.
Each serving provides 400mg of nattokinase enzyme delivering 8,000 fibrinolytic units, which is four times the standard 2,000 FU dose found in many competing products. The formula is non-GMO and manufactured in the USA in GMP-certified facilities. Each bottle contains 60 capsules for a full month’s supply at the recommended 2-capsule serving. The high potency makes this an excellent choice for those who want maximum nattokinase activity without taking multiple capsules from lower-dose products.
Pros:
High 8,000 FU potency — four times many competitors
USA-made in GMP-certified facilities
Non-GMO, clean formula with no unnecessary fillers
Cons:
Higher price per bottle than basic 2,000 FU options
Contains soy (derived from fermented soybeans)
Best for: Anyone who wants a high-potency nattokinase from a quality USA manufacturer
2. Luma Nutrition Nattokinase 4000 FU – Best Value
Luma Nutrition Nattokinase Supplement – Natto 4000 FU Per Serving, Premium Heart Health Support – Vegan & Gluten Free – 60 Capsules – Made in USA
Premium Natto Extract: Luma Nutrition’s powerful nattokinase supplement boasts superior quality and a powerful dosage of Nattokinase 4000 fu, twice as strong as other nattokinase 2000 fu products. These effective Nattokinase powder capsules promote healthy blood flow and circulation, supporting cardiovascular function and overall heart health.
Natural Heart Support: Nattokinase is an enzyme extracted from natto, a traditional Japanese fermented soybean dish. It’s renowned for its fibrinolytic properties, meaning it helps break down fibrin, a protein involved in restricted blood flow. Without the presence of Serrapeptase or Lumbrokinase, this supplement works for vegan or gluten-free diets.
30 Day Supply: Each bottle of Luma’s nattokinase supplement organic lasts for a month to maintain optimal freshness and provides natural heart health support. This nattokinase supplement for men and women makes the perfect monthly subscription.
3rd Party Tested: All of our products are 3rd party tested for purity and quality. Our Nattokinase is made in the USA in our fully certified facility. Non-gmo and the highest quality.
Proudly USA: All Luma Nutrition supplements are manufactured in GMP certified facilities in the United States to ensure product safety and quality is always upheld. Certificed by NSF December 2023. We are veteran owned and operated.
Luma Nutrition delivers a solid 4,000 FU per serving with third-party testing and GMP certification at a price point that makes daily nattokinase supplementation very affordable.
Each serving provides 4,000 FU of nattokinase enzyme — twice the standard 2,000 FU dose — in easy-to-swallow capsules. Luma Nutrition is a USA-based brand that third-party tests all products for purity and quality. The formula is vegan, gluten-free, and manufactured in GMP-certified facilities. Each bottle contains 60 capsules for a 30-day supply, making it an excellent balance of potency and affordability.
Pros:
4,000 FU per serving at an affordable price
Third-party tested and GMP-certified
Vegan and gluten-free formula
Cons:
30-day supply per bottle requires monthly reordering
Contains trace soy from nattokinase extraction
Best for: Budget-conscious users who want a potent, quality nattokinase without overpaying
3. Double Wood Nattokinase 4000 FU – Best Seller
Nattokinase Supplement 4,000 FU Servings, 120 Capsules (Derived from Japanese Natto) Systemic Enzymes for Cardiovascular and Circulatory Support by Double Wood
CARDIOVASCULAR HEALTH: Nattokinase may help support a healthy circulatory system by lowering plasma levels of certain proteins that affect circulation
CIRCULATORY SUPPORT: Research suggests that Nattokinase may help support cardiovascular health by promoting a healthy circulatory system
DERIVED FROM SOY (JAPANESE NATTO): Since Nattokinase is derived from fermented soybeans (Japanese Natto), there may be trace amounts of soy in the product. Do not take it if you are allergic to soy
TWO-MONTH SUPPLY: Our Nattokinase supplement contains 60 servings of 200 mg (4,000 FU), which equals 120 capsules (100 mg, 2,000 FU per capsule)
ROOTED IN QUALITY: Double Wood’s Nattokinase is manufactured right here in the USA from Globally Sourced Ingredients, Vegetarian, Non-GMO, and gluten-free
Double Wood’s nattokinase is one of the top-selling options on Amazon, delivering 4,000 FU per serving in a two-month supply bottle that has earned thousands of positive reviews.
Each serving consists of two capsules providing 200mg (4,000 FU) of nattokinase derived from Japanese natto. The 120-capsule bottle provides a full two-month supply, doubling the value of many 60-count competitors. Double Wood manufactures in the USA, and the product is vegetarian, non-GMO, and gluten-free. This is a straightforward, no-frills nattokinase that consistently ranks among the most popular options for cardiovascular and circulatory support.
Pros:
120-capsule bottle provides a full two-month supply
Amazon’s Choice with thousands of verified reviews
USA-manufactured, vegetarian, and non-GMO
Cons:
Requires two capsules per serving to reach 4,000 FU
Contains trace soy
Best for: Those who want a proven, highly reviewed nattokinase with a generous two-month supply
4. Doctor’s Best Nattokinase 2000 FU – Best Trusted Brand
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Doctor’s Best has been a trusted supplement brand for over 35 years, and their nattokinase delivers a research-backed 2,000 FU per capsule with vitamin K2 removed for those on anticoagulant protocols.
Each vegetarian capsule provides 2,000 FU of nattokinase with vitamin K2 specifically removed from the natto extract. This is an important distinction for people who are monitoring vitamin K intake or taking blood-thinning medications, as vitamin K can interfere with anticoagulant therapy. The product is non-GMO, vegan, and gluten-free. Doctor’s Best is known for science-backed formulations and transparent labeling. For those interested in comprehensive heart health supplements, this pairs well with CoQ10 and omega-3s.
Pros:
Vitamin K2 removed — important for those on blood thinners
35+ year trusted brand with science-backed formulations
Vegan capsule format, non-GMO and gluten-free
Cons:
2,000 FU per capsule is on the lower end of effective dosing
Smaller 90-count bottle means more frequent reordering
Best for: Those who need nattokinase with vitamin K removed, especially statin or anticoagulant users
5. Toku Nattokinase 10,800 FU – Most Potent
Toku Nattokinase 10,800 FU Supplement with Vitamin K2 MK7 & Oat Beta Glucan, Daily Circulation Support Powder, Plant-Based Drink Mix, Soy-Free, 30 Single-Serve Packets
DAILY WELLNESS SUPPORT: Toku Flow is a once-daily powder designed to support heart and vascular health with functional ingredients rooted in Eastern wellness traditions and backed by science.
CLINICALLY STUDIED NATTOKINASE: Delivers 10,800 FU of nattokinase, an enzyme derived from fermented Japanese natto, to help promote healthy blood flow and encourage natural enzyme activity in the body.
VITAMIN K2 FOR CALCIUM BALANCE: Includes 180 mcg of Vitamin K2 MK7 to help support proper calcium utilization and vascular health by guiding calcium toward the bones and away from soft tissues.
BETA GLUCAN FROM ORGANIC OAT BRAN: Provides 3g of organic oat bran per serving, standardized to 10% beta glucan, a naturally occurring soluble fiber known to help support internal balance and healthy nutrient metabolism.
PURE, PLANT-BASED FORMULA: A vegan-friendly powder that blends easily into water or your favorite beverage, free from soy and synthetic additives—offering gentle, effective support without pharmaceuticals.
Toku offers the highest-potency nattokinase available at 10,800 FU per serving, paired with vitamin K2 MK-7 and oat beta-glucan for comprehensive cardiovascular support.
Each serving delivers 10,800 FU of soy-free nattokinase — over five times the standard 2,000 FU dose. The formula also includes vitamin K2 (MK-7) for bone and arterial health, plus oat beta-glucan for cholesterol support. Toku specializes in nattokinase products and uses a soy-free extraction process, making it suitable for those with soy allergies. The multi-ingredient approach makes this a cardiovascular support stack in a single supplement.
Pros:
Industry-leading 10,800 FU potency
Soy-free nattokinase — rare in the category
Added vitamin K2 and oat beta-glucan for heart health
Cons:
Contains vitamin K2, which is not suitable for those on anticoagulants
Higher price point reflects the premium potency and ingredients
Best for: Those seeking maximum nattokinase potency with added cardiovascular ingredients in a soy-free format
6. Spike Detox Nattokinase 10,000 FU – Best Enzyme Blend
Atherionyxora Spike Detox – Nattokinase Supplement 10,000 FU with Serrapeptase 18,000 SPU & Bromelain 800 GDU – 3-in-1 Systemic Multi-Enzyme Formula for Heart – 90 Tablets
3-in-1 High-Potency Multi-Enzyme Formula: Spike Support Supplement combines Nattokinase (10,000 FU), Serrapeptase (18,000 SPU), and Bromelain (800 GDU) in a 3-in-1 multi-enzyme blend for protein breakdown, circulatory clarity, and balanced inflammatory response
Herbal & Antioxidant Support Blend: Herbal & Antioxidant Blend with NAC, black seed, dandelion, turmeric, and quercetin, forming a comprehensive herbal antioxidant complex designed for natural antioxidant properties, gentle internal cleansing, and overall formula synergy
High Absorption & Bioavailability: Black pepper extract combined with turmeric and quercetin in this multi-enzyme and herbal formula for efficient ingredient utilization
Enteric-Coated Technology for Precise Release: Protects active enzymes from stomach acid, ensuring stable release in the intestines for optimal potency and systemic benefits
Clean & Trusted Formula: Gluten-free, soy-free, and free from artificial colors or preservatives, making it suitable for those seeking a pure, high-quality supplement
This multi-enzyme formula combines 10,000 FU of nattokinase with serrapeptase and bromelain, creating a comprehensive systemic enzyme blend for fibrin breakdown and inflammatory support.
Each serving delivers 10,000 FU of nattokinase alongside 18,000 SPU of serrapeptase and bromelain. The triple-enzyme approach targets fibrin from multiple pathways, making it popular among those seeking comprehensive proteolytic enzyme support. The formula is designed for systemic enzyme activity beyond just cardiovascular support, addressing inflammation and overall circulatory wellness. For related circulation support, explore circulation supplements that complement nattokinase.
Pros:
Triple-enzyme formula with nattokinase, serrapeptase, and bromelain
10,000 FU nattokinase potency
Targets both fibrin breakdown and inflammatory pathways
Cons:
Multi-enzyme formulas may not suit everyone
Higher price due to the multi-ingredient profile
Best for: Users who want a comprehensive systemic enzyme formula combining nattokinase with other proteolytic enzymes
7. Horbäach Nattokinase 4000 FU – Best Budget Pick
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Horbäach Nattokinase Supplement 4000 FU | 150 Capsules | Non-GMO, Gluten Free
NATTOKINASE: This powerful enzyme is derived from the Japanese soybean called Natto
INNOVATIVE SUPPORT: Delivers 4000 FUs of Nattokinase per serving in convenient quick-release capsules
EXPERTLY CRAFTED: Our professional formula is backed by our commitment to purity and potency
HORBAACH MANUFACTURERS: Laboratory Tested, Trusted Ingredients, Superior Quality, 100% Guaranteed!
NATURALLY FREE OF: Gluten, Wheat, Milk, Lactose, Artificial Flavor, Color, Preservatives & Non-GMO
Horbäach delivers 4,000 FU of nattokinase per serving in a generous 150-capsule bottle, providing one of the best cost-per-serving values in the entire nattokinase category.
Each two-capsule serving provides 4,000 FU of nattokinase in quick-release capsules. The 150-count bottle provides a 75-day supply, significantly more than most 60-count competitors. Horbäach is a brand with 40+ years in the natural products industry, known for affordable, laboratory-tested supplements. The formula is non-GMO, gluten-free, and free from artificial flavors, colors, and preservatives.
Pros:
150-count bottle provides outstanding value per serving
40+ year brand history with laboratory-tested quality
Non-GMO, gluten-free with no artificial additives
Cons:
Requires two capsules per serving
Uses gelatin capsules (not vegan-friendly)
Best for: Budget shoppers who want a high-count bottle of nattokinase from an established brand
8. Pure Encapsulations NSK-SD Nattokinase – Best Premium
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Pure Encapsulations uses NSK-SD, the most clinically studied form of nattokinase with vitamin K2 removed, in a hypoallergenic formula designed for maximum purity and tolerability.
Each capsule provides 100mg of NSK-SD nattokinase delivering 2,000 FU. NSK-SD is the specific nattokinase extract used in much of the published clinical research on fibrinolytic activity and cardiovascular support. Pure Encapsulations is known for hypoallergenic formulas free from common allergens, artificial additives, and unnecessary excipients. The vitamin K2 has been removed during processing, making it suitable for those on anticoagulant therapy.
Pros:
Uses clinically studied NSK-SD nattokinase extract
Hypoallergenic, free from major allergens and fillers
Vitamin K2 removed for anticoagulant compatibility
Cons:
2,000 FU per capsule requires doubling for higher potency needs
Premium price reflects the clinical-grade ingredient sourcing
Best for: Those who want the most clinically validated form of nattokinase in a hypoallergenic, pure formulation
9. Toku Flow Nattokinase Powder 10,800 FU – Best Powder
Toku Nattokinase 10,800 FU Supplement with Vitamin K2 MK7 & Oat Beta Glucan, Daily Circulation Support Powder, Plant-Based Drink Mix, Soy-Free, 30 Single-Serve Packets
DAILY WELLNESS SUPPORT: Toku Flow is a once-daily powder designed to support heart and vascular health with functional ingredients rooted in Eastern wellness traditions and backed by science.
CLINICALLY STUDIED NATTOKINASE: Delivers 10,800 FU of nattokinase, an enzyme derived from fermented Japanese natto, to help promote healthy blood flow and encourage natural enzyme activity in the body.
VITAMIN K2 FOR CALCIUM BALANCE: Includes 180 mcg of Vitamin K2 MK7 to help support proper calcium utilization and vascular health by guiding calcium toward the bones and away from soft tissues.
BETA GLUCAN FROM GLUTEN FREE OAT BRAN: Provides 3g of oat bran per serving, standardized to 10% beta glucan, a naturally occurring soluble fiber known to help support internal balance and healthy nutrient metabolism.
PURE, PLANT-BASED FORMULA: A vegan-friendly powder that blends easily into water or your favorite beverage, free from soy and synthetic additives—offering gentle, effective support without pharmaceuticals.
Toku Flow delivers 10,800 FU of soy-free nattokinase in a functional daily powder format, offering a unique alternative for those who prefer mixing their supplements into beverages.
Each serving of this functional daily powder provides 10,800 FU of nattokinase alongside vitamin K2 MK-7, making it one of the most potent nattokinase products in any format. The powder dissolves in water or other beverages and is soy-free, addressing a common concern with nattokinase products. Toku specializes in nattokinase-based cardiovascular supplements and uses a proprietary extraction process.
Pros:
Powder format is ideal for those who dislike swallowing capsules
10,800 FU ultra-high potency per serving
Soy-free extraction process
Cons:
Powder format is less convenient for on-the-go use
Contains vitamin K2, not suitable for anticoagulant users
Best for: People who prefer powder supplements and want maximum-potency soy-free nattokinase
How to Choose the Best Nattokinase Supplement
The most important factor in choosing a nattokinase supplement is potency, which should always be listed in fibrinolytic units (FU) rather than just milligrams. A product listing only milligrams without FU does not tell you how active the enzyme actually is, since nattokinase potency varies depending on manufacturing and extraction methods. Most research uses doses of 2,000-4,000 FU daily, though higher-potency products offering 8,000-10,000 FU are becoming increasingly popular for more robust cardiovascular support. When comparing products, always look at the FU per serving, not just the number of capsules or milligrams.
Pay attention to whether the product has vitamin K2 removed. Nattokinase is naturally derived from natto, which is rich in vitamin K2. While vitamin K2 is beneficial for bone and arterial health in most people, it can interfere with anticoagulant medications like warfarin. If you take blood thinners, choose a nattokinase product specifically labeled as “vitamin K2 removed” or “NSK-SD.” For those not on anticoagulants, products that retain vitamin K2 or add it intentionally can provide additional cardiovascular benefits, as K2 helps direct calcium into bones and away from artery walls.
Capsules are the most common and effective delivery format for nattokinase. Look for vegetarian capsules if that aligns with your dietary preferences, as some products use gelatin. Enteric-coated options may provide additional protection for the enzyme through stomach acid, though standard capsules are generally effective. Powder formats are also available for those who prefer mixing supplements into drinks, and can offer very high potency per serving.
Quality indicators to look for include third-party testing, GMP certification, and manufacturing in the USA. Products using the NSK-SD extract have the most clinical research backing their fibrinolytic activity and are considered the gold standard by many practitioners. Also consider whether the product is soy-free, as most nattokinase is derived from fermented soybeans and may contain trace soy allergens — several brands now offer soy-free alternatives. For a broader approach to cardiovascular support, nattokinase pairs well with hawthorn berry, CoQ10, and omega-3 supplements.
Frequently Asked Questions
What is nattokinase and what does it do?
Nattokinase is a proteolytic enzyme extracted from natto, a traditional Japanese food made by fermenting soybeans with Bacillus subtilis bacteria. It is primarily studied for its fibrinolytic properties — meaning it helps break down fibrin, a protein involved in blood clot formation. This activity supports healthy blood flow, cardiovascular function, and circulatory wellness. Research also suggests potential benefits for blood pressure regulation and maintaining healthy cholesterol levels. Nattokinase has been consumed in Japan for centuries through natto, though the enzyme was first isolated and identified by Japanese researcher Dr. Hiroyuki Sumi in 1987. Since then, it has become one of the most studied natural fibrinolytic agents available.
How much nattokinase should I take daily?
Most studies and manufacturers recommend 2,000-4,000 FU (fibrinolytic units) daily for general cardiovascular support. Some higher-potency products deliver 8,000-10,000 FU for more intensive use. Always follow the specific product’s recommended dosage and consult a healthcare provider before starting, especially if you take blood-thinning medications.
When is the best time to take nattokinase?
Nattokinase is most commonly taken on an empty stomach, between meals, for optimal enzyme activity. Taking it away from food allows the enzyme to enter the bloodstream more effectively rather than being used for digestive purposes. Many people take it first thing in the morning or before bed. Some research suggests evening dosing may better support overnight circulatory function.
Are there any side effects of nattokinase?
Nattokinase is generally well-tolerated at recommended doses. Some people experience mild digestive discomfort when first starting supplementation. The primary concern is its blood-thinning properties — people taking anticoagulant medications (warfarin, heparin, aspirin), those with bleeding disorders, or anyone scheduled for surgery should consult a healthcare provider before use. Nattokinase derived from soy may trigger allergic reactions in soy-sensitive individuals.
Can I take nattokinase with other supplements?
Nattokinase pairs well with many cardiovascular support supplements including CoQ10, omega-3 fatty acids, magnesium, and hawthorn berry. However, exercise caution when combining nattokinase with other blood-thinning supplements like fish oil, vitamin E, garlic, or ginkgo biloba, as the combined effect may increase bleeding risk. Always inform your healthcare provider about all supplements you take.
How long does it take for nattokinase to work?
Some fibrinolytic activity can be measured within hours of taking nattokinase, with peak blood levels typically occurring 4-6 hours after ingestion. However, cumulative cardiovascular benefits generally develop over 4-8 weeks of consistent daily supplementation. Studies measuring blood pressure improvements have typically run 4-8 weeks to see meaningful changes.