Best Endurance Supplements for Runners (2026)

Endurance supplements for runners target the specific demands of distance training — reducing lactic acid buildup, increasing oxygen delivery, supporting energy production, and speeding recovery between sessions. The best formulas use research-backed ingredients like beetroot nitrates, beta-alanine, electrolytes, and iron to help runners train harder, recover faster, and perform at their peak on race day.

Quick Comparison

Product
Key Ingredient
Form
Best For
Rating

PurePremium Beet Root Capsules
Beetroot, CoQ10, Hawthorn
Capsules
Best Overall
9.5/10

Snap Supplements Organic Beet Root Powder
Organic Beetroot
Powder
Best Beet Root Powder
9.4/10

Xendurance Extreme Endurance
Lactic Acid Buffer Complex
Tablets
Best for Lactic Acid Reduction
9.3/10

Iron Brothers Nitric Oxide
L-Arginine, L-Citrulline
Capsules
Best Nitric Oxide Booster
9.2/10

Snap Supplements Beet Root Gummies
Beetroot, Pomegranate
Gummies
Best Gummies
9.1/10

SPORTLEGS Fast Fitness Boost
Lactate Compound
Capsules
Best Pre-Race Supplement
9.0/10

Nuun Sport Electrolyte Tablets
Sodium, Potassium, Magnesium
Effervescent Tablets
Best Electrolyte Support
8.9/10

1. PurePremium Beet Root Capsules – Best Overall

PurePremium delivers a comprehensive 14-in-1 beet root formula that combines beetroot powder with CoQ10, hawthorn berry, and grapeseed extract for multi-pathway endurance and circulation support.

This formula goes beyond basic beetroot supplementation by including ingredients that support cardiovascular health, oxygen utilization, and antioxidant protection — all critical for distance runners. The beetroot provides dietary nitrates that convert to nitric oxide for improved blood flow and oxygen delivery to working muscles, while CoQ10 supports mitochondrial energy production. Each bottle provides a full month’s supply in easy-to-swallow capsules.

Pros:

14-in-1 formula addresses multiple endurance performance factors

CoQ10 supports cellular energy production during long runs

Grapeseed extract provides additional antioxidant protection

Cons:

Multi-ingredient formula means lower individual doses

Capsule format rather than powder for pre-run mixing

Best for: Runners who want an all-in-one endurance supplement covering nitric oxide, energy production, and cardiovascular support

2. Snap Supplements Organic Beet Root Powder – Best Beet Root Powder

Snap Supplements offers USDA-certified organic beetroot powder that delivers a concentrated dose of dietary nitrates in a mixable format perfect for pre-run preparation.

This pure organic beet root powder provides nitric oxide precursors that research has shown can improve endurance performance, reduce oxygen cost during exercise, and enhance time to exhaustion. The powder format allows for flexible dosing and can be mixed into water, smoothies, or juice before training. Snap Supplements uses USDA-certified organic beetroot with no artificial colors, flavors, or sweeteners, and the product is third-party tested.

Pros:

USDA-certified organic beetroot with no artificial additives

Powder format allows flexible dosing and easy pre-run mixing

Research-backed nitrate supplementation for endurance improvement

Cons:

Earthy beet flavor may not appeal to all palates

Requires mixing rather than grab-and-go convenience

Best for: Runners who prefer a clean, organic powder format for their pre-run nitrate supplementation

3. Xendurance Extreme Endurance – Best for Lactic Acid Reduction

No products found.

Xendurance’s flagship formula is clinically proven to reduce lactic acid by 26% and increase aerobic threshold, making it a staple among serious endurance athletes from marathon runners to triathletes.

Extreme Endurance is backed by 12 clinical studies, including two gold-standard double-blind, placebo-controlled trials published in peer-reviewed journals. The formula acts as a lactic acid buffer, helping runners sustain higher intensity efforts for longer before fatigue sets in. Each bottle contains 180 tablets for a 30-day supply. The product is Informed Sport certified, meaning every batch is tested for banned substances — critical for competitive runners. It contains no caffeine or stimulants.

Pros:

Clinically proven to reduce lactic acid by 26% in published studies

Informed Sport certified for competitive athletes

Stimulant-free and caffeine-free for any time of day

Cons:

Premium price point reflects clinical research investment

Requires 3-5 days of loading before peak effects

Best for: Competitive runners and triathletes seeking clinically validated lactic acid reduction and endurance improvement

4. Iron Brothers Nitric Oxide – Best Nitric Oxide Booster

Iron Brothers provides a potent nitric oxide pre-workout formula with L-arginine, L-citrulline, and beetroot extract specifically designed to enhance blood flow and oxygen delivery during endurance training.

This formula combines the two most effective nitric oxide precursors — L-arginine and L-citrulline — with beetroot extract for triple-pathway NO production. For runners, increased nitric oxide means improved blood flow to working leg muscles, better oxygen utilization, and reduced perceived effort during long runs. The capsule format is convenient for race-day use and travel to events.

Pros:

Triple-pathway nitric oxide support with arginine, citrulline, and beetroot

Convenient capsule format for race-day travel

Clean formula without artificial additives

Cons:

Proprietary blend obscures exact ingredient amounts

May need to be taken well before running to avoid stomach discomfort

Best for: Runners who want comprehensive nitric oxide support for improved oxygen delivery and reduced perceived effort

5. Snap Supplements Beet Root Gummies – Best Gummies

Snap Supplements makes beetroot supplementation enjoyable with sugar-free cherry-flavored gummies that combine beetroot with pomegranate powder for nitric oxide and antioxidant support.

Each serving of these gummies delivers concentrated beetroot alongside pomegranate powder, which adds polyphenol antioxidants that help combat exercise-induced oxidative stress. The sugar-free formula avoids the GI issues that sugar-heavy gummies can cause during training. Each bag provides 60 gummies for a full month of daily endurance support. These are an ideal option for runners who dislike swallowing capsules or mixing powders.

Pros:

Sugar-free gummy format that’s easy and enjoyable to take

Added pomegranate provides antioxidant recovery support

No mixing or pill-swallowing required

Cons:

Lower nitrate concentration compared to powder or capsule forms

Gummy format may not deliver as many active compounds per serving

Best for: Runners who want a convenient, tasty alternative to capsules and powders for daily beetroot supplementation

6. PurePremium Beet Root 3-in-1 – Best with CoQ10

PurePremium’s 3-in-1 formula pairs concentrated beetroot with CoQ10 and grapeseed extract for a targeted endurance stack addressing blood flow, cellular energy, and antioxidant protection.

This streamlined formula focuses on three key areas for runners: beetroot nitrates for vasodilation and oxygen delivery, CoQ10 for mitochondrial energy production in muscle cells, and grapeseed extract for cardiovascular support and antioxidant defense against exercise-induced free radicals. The simplified 3-in-1 approach offers higher individual ingredient doses compared to larger multi-ingredient blends.

Pros:

Focused 3-ingredient formula with higher individual doses

CoQ10 supports energy production at the cellular level

Grapeseed extract provides cardiovascular and antioxidant benefits

Cons:

Capsule format may not suit pre-run mixing preferences

Fewer supporting ingredients than comprehensive multi-formulas

Best for: Runners who prefer a streamlined formula targeting the three most impactful endurance performance factors

7. SPORTLEGS Fast Fitness Boost – Best Pre-Race Supplement

No products found.

SPORTLEGS uses a unique lactate compound approach to pre-load muscles before exercise, helping runners manage the burn and sustain pace during races and hard training sessions.

Unlike most endurance supplements that work through nitric oxide, SPORTLEGS takes a different approach by providing European lactate compounds that prime muscles before exercise. The concept is based on research suggesting that pre-loading with lactate helps the body manage lactic acid more efficiently during intense efforts. The formula is NSF Certified for Sport, stimulant-free, and has been trusted by endurance athletes for over a decade. Take it 30 minutes before running for best results.

Pros:

Unique lactate-based approach different from standard NO boosters

NSF Certified for Sport for competitive athletes

Stimulant-free with no caffeine or banned substances

Cons:

Must be taken before each workout rather than building up over time

Individual results vary more than with beetroot supplementation

Best for: Competitive runners looking for a race-day supplement to manage lactic acid buildup during high-intensity efforts

8. Nuun Sport Electrolyte Tablets – Best Electrolyte Support

No products found.

Nuun Sport provides essential electrolytes — sodium, potassium, magnesium, and calcium — in a convenient effervescent tablet that dissolves in water for optimal hydration during long runs.

Proper electrolyte balance is fundamental to endurance performance, and Nuun Sport delivers the key minerals lost through sweat without excess sugar or calories. Each tablet dissolves in 16 oz of water and provides a balanced electrolyte profile designed specifically for athletes. The low-calorie formula avoids GI distress that high-sugar sports drinks can cause during running. Available in multiple flavors, Nuun is one of the most trusted hydration brands among marathon and ultra runners.

Pros:

Clean electrolyte formula with minimal calories and sugar

Convenient effervescent tablets that dissolve quickly

Trusted by marathon and ultra-distance runners worldwide

Cons:

Electrolytes only — doesn’t address nitric oxide or lactic acid

Mild flavor may not satisfy those who prefer sweeter sports drinks

Best for: Runners needing reliable electrolyte replacement during long training runs and races without excess sugar

How to Choose the Best Endurance Supplement for Running

The most research-backed endurance supplement for runners is beetroot, thanks to its high dietary nitrate content. Studies consistently show that beetroot supplementation can improve running economy by 1-3%, reduce oxygen cost during submaximal exercise, and extend time to exhaustion. For optimal results, look for products providing at least 300-500mg of dietary nitrates per serving, and consider loading for 3-6 days before an important race.

Electrolyte supplementation is essential for runners training over 60 minutes or in hot conditions. Sodium is the primary electrolyte lost through sweat, with runners losing 500-1500mg per hour depending on individual sweat rates and intensity. Potassium, magnesium, and calcium also play critical roles in muscle contraction and nerve signaling. Choose electrolyte products with minimal sugar to avoid GI distress during running.

Iron is often overlooked but critically important for endurance athletes, particularly female runners. Iron deficiency affects up to 50% of female runners and 30% of male runners, leading to fatigue and decreased performance. If you experience unexplained fatigue or declining performance, have your iron levels tested before supplementing, as excessive iron can be harmful.

Consider your training phase when selecting supplements. Beta-alanine and creatine may benefit runners doing speed work and interval training, while beetroot and electrolytes are most valuable for longer endurance efforts. Caffeine (3-6mg per kg body weight) is one of the most proven ergogenic aids for running performance, reducing perceived effort by 2-4% in studies. For race-day use, always test any new supplement during training first.

Frequently Asked Questions

What supplements actually help running endurance?

The most evidence-backed supplements for running endurance include beetroot (dietary nitrates), caffeine, beta-alanine, creatine monohydrate, and electrolytes. Beetroot supplementation has been shown to improve running economy and extend time to exhaustion. Caffeine reduces perceived exertion by 2-4%. Beta-alanine helps buffer lactic acid during high-intensity intervals, and electrolytes maintain hydration and muscle function during long efforts.

When should runners take endurance supplements?

Timing depends on the supplement. Beetroot is most effective when taken 2-3 hours before running, though daily supplementation for 3-6 days before an event maximizes nitrate levels. Caffeine peaks in the blood 30-60 minutes after consumption. Electrolytes should be consumed before, during, and after runs lasting over 60 minutes. Beta-alanine works through daily loading rather than acute pre-workout timing.

Is beetroot really effective for runners?

Yes, beetroot is one of the most well-supported endurance supplements in sports nutrition research. Multiple systematic reviews and meta-analyses confirm that dietary nitrate supplementation from beetroot can reduce oxygen cost during submaximal exercise, improve time to exhaustion, and enhance running economy. The effects are most pronounced in recreational to moderately trained runners and during longer endurance efforts.

Can endurance supplements replace proper training?

No supplement can replace consistent, structured training. Endurance supplements provide marginal performance improvements of 1-5% at best, which can be meaningful in competition but are secondary to proper training, nutrition, sleep, and recovery. Think of supplements as the final 1-3% optimization after your training base, diet, hydration, and recovery protocols are already dialed in.

Are endurance supplements safe for competitive runners?

Most natural endurance supplements like beetroot, electrolytes, and caffeine are safe and permitted by all sports governing bodies. However, runners subject to anti-doping testing should look for third-party certifications like Informed Sport or NSF Certified for Sport, which verify that products are free from banned substances. Always check the current WADA prohibited list and avoid any supplement with unfamiliar proprietary blends.

How long do endurance supplements take to work?

Acute supplements like caffeine and beetroot juice can produce noticeable effects within a single session (30-180 minutes after consumption). Daily supplements like beta-alanine and creatine require a loading phase of 2-4 weeks before reaching peak effectiveness. Lactic acid buffers like Xendurance Extreme Endurance typically need 3-5 days of consistent use before users notice significant improvements in endurance and recovery.