L-arginine is a semi-essential amino acid that serves as a precursor to nitric oxide (NO) — a molecule critical for blood vessel dilation, healthy circulation, and cardiovascular function. Supplementing with L-arginine supports blood flow, exercise performance, blood pressure regulation, and overall vascular health. The best L-arginine supplements deliver clinically effective doses in formats optimized for absorption and convenience.
Quick Comparison
Product
Key Ingredient
Form
Best For
Rating
Snap Supplements Nitric Oxide (150ct)
L-Arginine + Beet Root
Capsules
Best Overall
9.5/10
Snap Supplements Nitric Oxide (60ct)
L-Arginine + Beet Root
Capsules
Best Starter Size
9.4/10
Iron Brothers Nitric Oxide
L-Arginine + L-Citrulline
Capsules
Best for Workouts
9.3/10
Natures Craft Nitric Oxide
L-Arginine + Tribulus
Capsules
Best for Men’s Health
9.1/10
BioSchwartz L-Arginine + L-Citrulline
L-Arginine 1000mg + L-Citrulline
Capsules
Best Combo Formula
9.0/10
L-Arginine Gummies with Beet Root
L-Arginine + L-Citrulline + Beet
Gummies
Best Gummies
8.9/10
NOW L-Arginine 1000mg
Pure L-Arginine 1000mg
Tablets
Best Pure L-Arginine
8.8/10
1. Snap Supplements Nitric Oxide with L-Arginine (150ct) – Best Overall
Sale
Snap Supplements Nitric Oxide Supplement with L-Arginine to Support Energy, Quick Recovery, Heart Health, Muscle Growth & Circulation, 90 Vegetarian Capsules
Supports Oxygen Delivery & Natural Energy – Nitric Oxide plays a role in circulation and energy production, supporting healthy circulation and daily vitality. Our Nitric Oxide Booster supports natural nitric oxide levels and features ginseng root, traditionally used to promote stamina, endurance, and sustained energy—without stimulants or added sugars.
Promotes Healthy Circulation & Cardiovascular Wellness – By supporting healthy blood flow throughout the body, our nitric oxide supplement promotes natural circulation and helps maintain heart and overall circulatory wellness. This blend helps you stay active and feel good, naturally.
L-Arginine & L-Citrulline For Active Energy & Performance – Formulated with three forms of L-Arginine and L-Citrulline, key amino acids that help support the body’s natural nitric oxide production, this supplement promotes energy production, supports healthy immune function, and helps maintain muscle health and recovery. Because natural production may vary, supplementing with L-Arginine can help support circulation, stamina, workout endurance, and overall wellness for an active lifestyle.
Enhance Your Wellness Routine: Ideal for fitness enthusiasts and active adults who want to support natural energy, workout recovery, and healthy circulation. Best used alongside a balanced diet, regular exercise, and your favorite gym supplements. Convenient for use at home, in the gym, or on the go.
Quality You Can Trust: Our vitamins and supplements are crafted by health experts and manufactured in the USA with globally sourced ingredients. This supplement is non-GMO, free of major allergens, gluten-free, and manufactured in a GMP-certified facility to ensure purity, potency, and quality. It contains no gelatin, dairy, or other animal-derived substances – making it a great option for vegans & vegetarians.
A top-rated nitric oxide booster that combines L-arginine with beet root extract for dual-pathway NO production, supporting energy, circulation, and workout recovery in a generous 150-capsule bottle.
This formula pairs L-arginine with organic beet root powder, creating two complementary pathways to nitric oxide production — the L-arginine/NOS pathway and the nitrate/nitrite pathway from beet root. The result is more sustained NO elevation than either ingredient alone. Each serving delivers a clinically relevant L-arginine dose alongside beet root for enhanced vascular support. Made in a GMP-certified USA facility with vegetarian capsules.
Pros:
Dual-pathway NO production from L-arginine plus beet root
150-capsule bottle provides extended supply
Supports energy, circulation, and exercise recovery
Cons:
Multi-ingredient blend means less pure L-arginine per capsule
Requires 3 capsules per serving
Best for: Anyone who wants comprehensive nitric oxide support from multiple pathways
2. Snap Supplements Nitric Oxide with L-Arginine (60ct) – Best Starter Size
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Snap Supplements Nitric Oxide Supplement with L-Arginine to Support Energy, Quick Recovery, Heart Health, Muscle Growth & Circulation, 60 Vegetarian Capsules (1 Month Supply)
Supports Oxygen Delivery & Natural Energy – Nitric Oxide plays a role in circulation and energy production, supporting healthy circulation and daily vitality. Our Nitric Oxide Booster supports natural nitric oxide levels and features ginseng root, traditionally used to promote stamina, endurance, and sustained energy—without stimulants or added sugars.
Promotes Healthy Circulation & Cardiovascular Wellness – By supporting healthy blood flow throughout the body, our nitric oxide supplement promotes natural circulation and helps maintain heart and overall circulatory wellness. This blend helps you stay active and feel good, naturally.
L-Arginine & L-Citrulline For Active Energy & Performance – Formulated with three forms of L-Arginine and L-Citrulline, key amino acids that help support the body’s natural nitric oxide production, this supplement promotes energy production, supports healthy immune function, and helps maintain muscle health and recovery. Because natural production may vary, supplementing with L-Arginine can help support circulation, stamina, workout endurance, and overall wellness for an active lifestyle.
Enhance Your Wellness Routine: Ideal for fitness enthusiasts and active adults who want to support natural energy, workout recovery, and healthy circulation. Best used alongside a balanced diet, regular exercise, and your favorite gym supplements. Convenient for use at home, in the gym, or on the go.
Quality You Can Trust: Our vitamins and supplements are crafted by health experts and manufactured in the USA with globally sourced ingredients. This supplement is non-GMO, free of major allergens, gluten-free, and manufactured in a GMP-certified facility to ensure purity, potency, and quality. It contains no gelatin, dairy, or other animal-derived substances – making it a great option for vegans & vegetarians.
The same effective L-arginine and beet root formula in a 60-capsule bottle — ideal for first-time users who want to test the formula before committing to a larger supply.
This is the same proven nitric oxide formula as the 150-count bottle, offering L-arginine combined with organic beet root for synergistic NO production. The smaller bottle makes it a low-risk way to evaluate how L-arginine supplementation works for your body. Quick recovery support, energy enhancement, and circulation benefits in a formula backed by positive user reviews.
Pros:
Affordable trial size for new L-arginine users
Same proven formula as the larger bottle
Good balance of L-arginine and beet root extract
Cons:
Higher cost per serving than the 150-count option
20-day supply at recommended dose
Best for: First-time L-arginine users who want to try a proven formula at low commitment
3. Iron Brothers Nitric Oxide Supplement – Best for Workouts
Iron Brothers Nitric Oxide Supplement for Men & Women | Pre-Workout Nitric Oxide Booster for Enhanced Muscle Pump, Blood Flow & Endurance | L-Arginine, L-Citrulline, Pine Bark Extract | 120 Vegan Caps
Full, Energized Muscle Pump with Iron Brothers Nitric Oxide Supplement for Men & Women: Features a Quad-Action Nitric Oxide Formula with L-Arginine, L-Citrulline & Agmatine Sulfate to support a full muscle pump that lasts longer and doesn’t fade right away.
Support Healthy Blood Flow & Circulation: Our nitric oxide for women is formulated with Pine Bark Extract, Niacin & BioPerine, to support smooth circulation, efficient nutrient & oxygen delivery to active muscles – fueling your body during physical activity.
Boost & Sustain Your Nitric Oxide Levels with a Double-Lock Formula: This blend combines Niacin to support blood vessel dilation, maintain nitric oxide availability, and support sustained blood flow, endurance, and performance during intense workouts.
100% Caffeine-Free, Stimulant-Free Composition: Our pre-workout nitric oxide booster for men is designed to support clean workout energy & endurance without jitters or crashes. Ideal for late-day training or stacking with other performance supplements.
Vegan, Easy-To-Swallow Capsules with Maximum Absorption: What’s the point of a pump formula if your body can’t absorb it? Our nitric oxide capsules for men include black pepper extract to enhance nutrient uptake and absorb the key ingredients efficiently.
Designed as a pre-workout nitric oxide booster for both men and women, this formula combines L-arginine with L-citrulline, beet root, and pine bark extract for maximum muscle pump and endurance.
Iron Brothers delivers a stacked nitric oxide formula built for athletic performance. L-arginine provides the direct NO precursor, while L-citrulline recycles arginine for sustained production. Beet root adds dietary nitrates, and pine bark extract (a natural source of pycnogenol) enhances endothelial function. The multi-angle approach targets blood flow, oxygen delivery, and exercise capacity more effectively than L-arginine alone.
Pros:
Comprehensive pre-workout NO stack with 4+ active ingredients
L-citrulline extends L-arginine’s NO-boosting effects
Formulated for both men and women
Cons:
Proprietary blend doesn’t disclose exact per-ingredient doses
Not ideal for those who want pure L-arginine only
Best for: Athletes and gym-goers who want a comprehensive pre-workout NO booster
4. Natures Craft Nitric Oxide with L-Arginine – Best for Men’s Health
Natures Craft Energizing Nitric Oxide Supplement for Men – Nitric Oxide Pills for Men with L-Arginine L-Citrulline Amino Acids for Intense Muscle Growth Intense Energy and Smooth Recovery – 60 Count
Get those Gains – Our natural nitric oxide pre workout for men is powered by flavonoids and amino acids to increase nitric oxide levels and give you that ripped look
Natural formula – Unlike many other nitric oxide supplements for men our formula has no unnecessary additives to make space for extra L arginine and citrulline beet powder and AKG for real results
Amino acids supplement – Enhance your manly lifestyle with our muscle builder pre workout pills for better energy and size enlargement that won’t let you down in the gym or at home
Natural Energy – Just try our NO Rush preworkout energy pills and feel the Natures Craft difference in your daily exercise unlike so many other natural energy supplements for men
Natures Craft Quality – We are proud to be a leading name in natural mens health and muscle gainer bodybuilding supplements because we believe real results come from real ingredients you can trust
An energizing nitric oxide formula that combines L-arginine with tribulus terrestris, maca, and ginseng for men seeking both circulation support and overall vitality enhancement.
This formula goes beyond basic NO support by adding adaptogenic herbs and men’s health botanicals to the L-arginine base. Tribulus terrestris and maca root support energy and vitality, while ginseng provides adaptogenic stress support. The combination addresses circulation, physical performance, and men’s wellness in one daily supplement. Made with natural ingredients and free from artificial additives.
Pros:
Combines L-arginine with men’s health adaptogens
Tribulus and maca add energy and vitality support
Multi-benefit formula addresses circulation plus wellness
Cons:
Added herbs may not appeal to those wanting pure L-arginine
Primarily marketed toward men
Best for: Men who want L-arginine circulation support combined with energy and vitality herbs
5. L-Arginine 1000mg with L-Citrulline – Best Combo Formula
L-Arginine Capsules with L-Citrulline – Nitric Oxide Supplement – L Arginine and L Citrulline Blend – 120 Count – Vegan, Non-GMO Capsules for Performance, Endurance and Muscle Support – 2 Month Supply
L-Arginine L-Citrulline Complex – Each serving contains a 1200mg blend of L-Arginine and L-Citrulline, ensuring maximum performance and muscle support during physical activities.
Supports Nitric Oxide Production – Our l arginine supplement for men and women helps support nitric oxide production, which may promote peak performance during exercise and support overall physical vitality.
Exercise Endurance – Fuel your active lifestyle with l-arginine for men and women, formulated to assist with endurance and recovery, helping you stay on top of your fitness goals.
Two-Month Supply – With 120 capsules per bottle, our L-Arginine and L-Citrulline supplement offers a convenient 2-month supply, providing long-term support for your fitness and wellness goals with ease.
Vegan & Non-GMO – Crafted with vegan and non-GMO ingredients, our L-Arginine capsules are produced to meet high standards, ensuring you get a reliable and hassle-free supplement for your active lifestyle.
A straightforward, high-dose combination of 1,000 mg L-arginine with L-citrulline that delivers the two most important amino acids for sustained nitric oxide production.
This supplement pairs L-arginine with L-citrulline in a clean, focused formula. L-citrulline is converted to L-arginine in the kidneys, effectively extending the duration of elevated arginine levels and NO production. The combination has shown superior results to L-arginine alone in clinical studies. Each capsule delivers a clear 1,000 mg L-arginine dose with complementary L-citrulline. No proprietary blends — you know exactly what you’re getting.
Pros:
Transparent dosing with 1,000 mg L-arginine per serving
L-citrulline enhances and extends NO production
Clean formula without unnecessary filler ingredients
Cons:
Basic formula without additional performance or cardiovascular support ingredients
Standard commission product without premium brand recognition
Best for: Those who want a straightforward, well-dosed L-arginine + L-citrulline combination
6. Nitric Oxide Gummies with L-Arginine and Beet Root – Best Gummies
Nitric Oxide Gummies for Men and Women with L-Arginine and Beet Root – NO Gummies for Endurance and Recovery – 90 Count – Green Apple and Cinnamon Flavor – Vegan, Non-GMO, 1 Month Supply
Nitric Oxide Booster – Formulated with l-arginine and beet root, our nitric oxide gummies support nitric oxide production, helping to enhance vitality and endurance for both men and women.
Endurance & Power – This nitric oxide supplement blends l-arginine HCI and beet root, offering powerful support that may promote performance and endurance during workouts, making it ideal for active lifestyles.
Training & Recovery Support – Combining L-arginine, beet root, and a plant-based S7 blend, these gummies support muscle endurance and promote faster recovery, helping you achieve better training results.
Bold Flavor – With a satisfying cinnamon bite, these nitric oxide gummies deliver a unique and adventurous taste sensation. While some enjoy the intense cinnamon heat, our pleasantly surprising yet spicy gummy is not for the weak! Try them for yourself and embark on a fun, spicy kick to help you with your workout.
Convenient & Vegan-Friendly – Our nitric oxide gummies offer a tasty and easy way to support your daily routine, crafted to be vegan, gluten-free, and non-GMO, suitable for both men and women.
A convenient gummy format that delivers L-arginine and beet root for nitric oxide support without swallowing capsules — ideal for those who prefer a tastier supplement experience.
These gummies combine L-arginine with beet root extract for dual-pathway NO support in a chewable format. Designed for both men and women, they target endurance, energy, and healthy blood flow. The gummy form makes them easy to incorporate into any daily routine, particularly for users who dislike taking multiple capsules. Natural flavoring with no artificial colors or preservatives.
Pros:
Tasty gummy format eliminates capsule fatigue
Combines L-arginine with beet root for synergistic NO support
Suitable for both men and women
Cons:
Lower L-arginine dose per serving compared to capsules
Contains added sugars typical of gummy supplements
Best for: Anyone who prefers gummies over capsules and wants basic L-arginine + beet root NO support
7. L-Arginine Gummies with L-Citrulline and Beet Root – Best Triple-Action Gummy
L-Arginine Gummies with L-Citrulline and Beet Root – Nitric Oxide Supplement – 90 Count – Energy, Endurance, and Recovery Support – Vegan, Non-GMO – Energizing Sour Berry Flavor, 30-Day Serving
Powerful Nitric Oxide Blend – Formulated with L-Arginine HCI, L-Citrulline, and Beet Root, these gummies help support nitric oxide production, making them ideal for both men and women seeking peak performance.
Delicious Sour Berry Flavor – Satisfy your taste buds with our tangy sour berry l arginine and l citrulline gummies, offering a delightful and energizing way to prepare for your workout.
L-Arginine & L-Citrulline Complex – Our gummy formula combines L-Arginine and L-Citrulline to aid in the production of nitric oxide, supporting your active lifestyle and fitness goals.
Workout Companion – Designed to help support exercise endurance and recovery, these gummies are a convenient pre-workout option for athletes and fitness enthusiasts aiming for a productive workout session.
Your Favorite Just Got Tastier – We took our fan-favorite l citrulline l arginine supplements for men, and made them into delicious gummies. These statements have not been evaluated by the Food and Drug Administration; this product is not intended to diagnose, treat, cure, or prevent any disease.
A triple-action nitric oxide gummy that combines L-arginine, L-citrulline, and beet root in one chewable serving for comprehensive vascular support without any pills.
This gummy delivers three NO-boosting ingredients in one convenient chew. L-arginine provides the direct NO precursor, L-citrulline recycles arginine for sustained production, and beet root adds dietary nitrates for additional vascular support. The 90-count bottle provides a full month’s supply. Designed for energy enhancement, endurance support, and healthy circulation in a pleasant-tasting format.
Pros:
Three NO-boosting ingredients in one gummy
No capsules to swallow — great for pill-averse users
90-count bottle provides good value
Cons:
Total amino acid dose lower than capsule alternatives
Added sweeteners necessary for gummy formulation
Best for: Users who want a triple-action NO supplement in gummy form
8. Vasonoxol Nitric Oxide Supplement 2880mg – Best for Blood Pressure
Vasonoxol U.S. Patented Nitric Oxide Supplement for Blood Pressure Support 2880mg – Physician Formulated Vascular Health Formula with L-Arginine & and L-Citrulline – Vegan, Non-GMO (360 Capsules)
CARDIOVASCULAR WELL-BEING – Vasonoxol is a nitric oxide supplement that promotes blood circulation. Our blood pressure supplements help with high blood pressure and may provide other cardiovascular benefits.
SUPPORT BLOOD PRESSURE—This original formulation of Vasonoxol high blood pressure supplements supports blood flow by providing more of the key nutrients your body needs. Always consult a physician before taking medication.
NATURAL INGREDIENTS – Vasonoxol blood pressure support supplement is herbal, GMO-free, and vegan-friendly. This natural formulation contains ginkgo biloba, horse chestnut, red yeast rice, cayenne and key amino acids L-arginine and L-citrulline.
U.S. PATENT—Vasonoxol is Panoxol. Our nitric oxide supplement, formulated by a physician, is patented by the United States Patent and Trademark Office. Patented formulas are a sign of quality and purity. Physicians recommend our natural formula for blood pressure.
ABOUT VASONOXOL—Dr. Richards first developed Vasonoxol, a nitric oxide supplement, for someone who needed holistic blood pressure support. It worked so well that he needed to share it with everyone. Behind our products are success stories of real people impacted by Panoxol’s benefits.
A patented, high-dose nitric oxide formula delivering 2,880 mg of active ingredients specifically formulated for blood pressure support and cardiovascular health.
Vasonoxol holds a US patent for its specific combination of L-arginine, L-citrulline, and supporting nutrients designed to optimize nitric oxide production for vascular health. The 2,880 mg total active dose is among the highest available in a capsule supplement. Clinical-grade formulation targets blood pressure regulation through sustained NO production. Manufactured in the USA in a GMP-certified facility.
Pros:
US-patented formula specifically for blood pressure support
High 2,880 mg total active ingredient dose
Clinical-grade formulation with transparent dosing
Cons:
Premium price point compared to basic L-arginine supplements
Multiple capsules per serving
Best for: Those specifically seeking L-arginine for blood pressure and cardiovascular support
How to Choose the Best L-Arginine Supplement
Effective L-arginine supplementation typically requires 2,000–6,000 mg per day, with most clinical studies using 3,000–6,000 mg for cardiovascular benefits. Look for products that clearly state the L-arginine dose per serving rather than hiding it in proprietary blends. Higher doses are generally needed for blood pressure and circulation benefits, while lower doses (1,500–3,000 mg) may be sufficient for general NO support and exercise performance.
Formulas that combine L-arginine with L-citrulline tend to produce better results than L-arginine alone. L-citrulline is converted to L-arginine in the body and helps maintain elevated arginine levels for a longer period. Beet root extract adds another NO pathway (the nitrate/nitrite route), creating even more comprehensive nitric oxide support. Multi-ingredient formulas targeting several NO pathways often outperform single-ingredient products.
Capsules and tablets offer higher doses per serving than gummies and are better suited for achieving clinically effective amounts. Gummies sacrifice potency for convenience and taste. Powder forms offer the highest flexibility for dosing but require mixing. For exercise performance, timing matters — take L-arginine 30–60 minutes before workouts for best results.
Quality markers include GMP-certified manufacturing, third-party testing, transparent ingredient labeling, and the use of L-arginine (the free-form amino acid) rather than cheaper arginine salts. Products made in the USA and tested for purity provide additional confidence. If you take blood pressure medications or blood thinners, consult your healthcare provider before starting L-arginine supplementation.
Frequently Asked Questions
What is L-arginine and what does it do?
L-arginine is a semi-essential amino acid that the body uses to produce nitric oxide (NO), a molecule that relaxes blood vessels, improves blood flow, and supports healthy blood pressure. It plays a role in immune function, wound healing, hormone signaling, and exercise performance. While the body produces some L-arginine naturally, supplementation can boost NO levels beyond what the body produces alone.
How much L-arginine should I take daily?
For general cardiovascular and circulation support, 2,000–6,000 mg per day is typical. For exercise performance, 3,000–6,000 mg taken 30–60 minutes before training is common. For blood pressure support, clinical studies generally use 4,000–6,000 mg daily divided into 2–3 doses. Start with a lower dose and increase gradually to assess tolerance.
When is the best time to take L-arginine?
For exercise performance, take L-arginine 30–60 minutes before workouts to maximize blood flow during training. For cardiovascular support, splitting the daily dose into 2–3 servings taken with meals provides more sustained NO elevation throughout the day. Taking it on an empty stomach may improve absorption but can cause GI discomfort in some people.
Are there any side effects of L-arginine?
Common side effects at higher doses include GI discomfort, bloating, diarrhea, and nausea. L-arginine can lower blood pressure, which is beneficial for many but may be problematic for those already on blood pressure medication or with naturally low blood pressure. People with herpes infections should use caution, as L-arginine may trigger outbreaks. Consult a healthcare provider if you take medications for blood pressure, diabetes, or blood clotting.
Can I take L-arginine with L-citrulline?
Yes — in fact, combining L-arginine with L-citrulline is one of the most effective strategies for sustained nitric oxide production. L-citrulline is converted to L-arginine in the kidneys, effectively recycling and extending arginine’s availability. Many researchers and supplement formulators consider this combination superior to either amino acid alone for NO enhancement and cardiovascular support.
How long does it take for L-arginine to work?
For acute effects like exercise performance and blood flow, L-arginine can begin working within 30–60 minutes of ingestion. For sustained cardiovascular benefits like blood pressure improvement, consistent daily supplementation for 2–4 weeks is typically needed before measurable changes occur. Maximum benefits for vascular health generally emerge after 4–12 weeks of consistent use.