The kidneys filter roughly 200 quarts of blood daily, removing waste, balancing electrolytes, and regulating blood pressure. Supporting kidney health with targeted supplements — especially those containing cranberry, astragalus, stinging nettle, and uva ursi — can help maintain optimal renal function and protect against oxidative stress that contributes to kidney decline.
Quick Comparison
Product
Key Ingredient
Form
Best For
Rating
PurePremium Kidney Support (60-Day)
Cranberry + Astragalus 21-in-1
Capsules
Best Overall
9.5/10
PurePremium Kidney Support (Original)
Cranberry + Astragalus 21-in-1
Capsules
Best Value
9.4/10
Snap Supplements Kidney Health
Cranberry + Grape Seed
Capsules
Best Plant-Based
9.2/10
Advanced Kidney Support
Cranberry + Uva Ursi + Nettle
Capsules
Best for Urinary Tract
9.0/10
Organic Cranberry Pills
Cranberry 50:1 Concentrate
Capsules
Best Cranberry Supplement
8.9/10
Natural Cranberry Gummies
Cranberry Extract
Gummies
Best Gummies
8.8/10
Tart Cherry Capsules
Tart Cherry 7500mg
Capsules
Best for Uric Acid Support
8.7/10
1. PurePremium Kidney Support Supplement (60-Day Supply) – Best Overall
PurePremium Kidney Support Supplement – Kidney Cleanse Detox & Repair with Cranberry Extract & Astragalus – 21-in-1 Complex Supports Normal Bladder, Urinary Tract & Kidneys Health – 120 Day Supply
3-In-1 Health Support – Support your normal kidney’s health with Pure Premium Kidney Supplement, which contains powerful herbal ingredients to help maintain and support a healthy normal kidney function, bladder health, and urinary tract health. Health support for a daily cleanse, detox and repair.
Advance Kidney Health Supplement – With advanced formulation to offer you all the essential nutrients to maintain your normal kidney health. A Cranberry extract capsules combined with powerful natural ingredients, for a day-to-day support for all-natural kidney cleanse & support for urinary tract health for women and men
All Natual Herbal Ingredients – Support urinary and bladder health by adding our kidney support capsules to your routine. Our kidney detox support supplement contains cranberry extract, astragalus, juniper berry powder, uva ursi leaf and nettle leaf extract.
Complete Kidney Support With Just One Tablet – You get a highly beneficial, all-natural fusion of Cranberry 30% Extract (VitaCran), Astragalus, Birch Leaf Powder, Gravel Root Powder, Goldenrod Grass Powder, Uva Ursi Leaf & Java Tea.
Formulated For Men & Women – Our proprietary formula, helps men and women hit reset and supports their normal kidney health the natural way. Formulated in the USA, Every PurePremium product comes from a facility based right here in the USA.
PurePremium’s 21-in-1 kidney support formula delivers the most comprehensive blend of kidney-protective ingredients available in a single capsule.
This advanced formula combines cranberry extract with astragalus root, ginger, turmeric, grape seed extract, nettle leaf, juniper berries, uva ursi, and chanca piedra among its 21 natural ingredients. Each component targets a different aspect of kidney health — from antioxidant protection to urinary tract support and detoxification. The 60-day supply offers extended value, and the capsules are free from GMOs, gluten, and preservatives. Manufactured in a GMP-certified facility.
Pros:
21 synergistic kidney-support ingredients in one capsule
60-day supply for consistent long-term use
Includes astragalus, cranberry, and chanca piedra — top kidney herbs
Cons:
Proprietary blend doesn’t list individual ingredient amounts
Large capsule size may be difficult for some to swallow
Best for: Anyone seeking the most comprehensive kidney health supplement available
2. PurePremium Kidney Support Supplement (Original) – Best Value
Sale
PurePremium Kidney Support Supplement – Kidney Cleanse Detox & Repair with Cranberry Extract & Astragalus – 21-in-1 Complex Supports Normal Bladder, Urinary Tract & Kidneys Health – 60 Day Supply
3-IN-1 HEALTH SUPPORT: PurePremium kidney support supplement provides all-in-one solution for kidney cleanse detox & repair, urinary tract health, and bladder support — in just 1 cranberry supplement capsule daily.*
ADVANCED CRANBERRY SUPPLEMENT: Our kidney health supplement offers a variety of nutrients for optimal kidney support. Each capsule includes cranberry powder, astragalus, ginger, turmeric, and grape seed extract supporting kidney flush and bladder heath.*
21 NATURAL INGREDIENTS: PurePremium kidney supplement combines 21 powerful ingredients, including nettle leaf, juniper berries, uva ursi, chanca piedra. Support your kidney detox effectively and simplify your health routine with our cranberry pills.*
QUALITY & PURITY: Our commitment to excellence shines through in every aspect of our kidney health vitamins. Free from GMOs, gluten, and preservatives, our kidney supplements are meticulously crafted to ensure purity and provide you with a trusted choice for your wellness needs.*
USA-MADE & LAB TESTED: PurePremium kidney vitamins are manufactured in a USA-based facility that complies with all cGMP standards. Additionally, each batch of our cranberry extract is tested by a third-party laboratory.*
The original PurePremium kidney formula that established the brand as a leader in renal health supplements, offering the same 21-ingredient complex at a competitive price.
This formula mirrors the advanced version with cranberry extract, astragalus, ginger, turmeric, and 17 additional kidney-supporting ingredients. It targets kidney cleansing, detox, and repair while also supporting bladder and urinary tract health. The capsules are vegetarian-friendly and manufactured under strict GMP standards. This is one of the top-selling kidney supplements on Amazon with thousands of verified reviews.
Pros:
Proven formula with extensive positive user feedback
Same 21-ingredient kidney complex as the premium version
Competitive pricing makes it accessible for long-term use
Cons:
Shorter supply than the 60-day version
Individual ingredient doses not disclosed
Best for: Budget-conscious buyers who want a proven, multi-ingredient kidney supplement
3. Snap Supplements Kidney Health Support – Best Plant-Based
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Snap Supplements Kidney Health Support Supplement – Kidney and Urinary Tract Health Support for Women and Men, 60 Vegetarian Capsules (30 Servings, 1 Month Supply)
Urinary System Support: We’ve formulated our Kidney Health supplement with plant-based ingredients that help support urinary tract wellness and overall vitality. Designed for adults seeking natural support for kidney and urinary function as part of a healthy lifestyle.
Supports Healthy Kidney Function: Crafted for daily use, this supplement features herbs and nutrients that help support kidney function and urinary wellness. Complements hydration and balanced nutrition for everyday self-care.
Powerful Plant-Based Ingredients: Formulated with organic cranberry, grape seed extract, and other botanicals traditionally used to support kidney and urinary wellness. This gentle, plant-based blend contains antioxidants that help support natural energy and digestive wellness—an ideal choice for health-conscious individuals who value a natural approach to daily supplementation.
Simple Everyday Wellness: Take daily as part of your wellness routine to help support kidney and urinary health. Fits seamlessly into any schedule—at home, work, or on the go. Best when paired with a balanced lifestyle, this supplement helps support overall wellness and vitality.
Quality You Can Trust: Our vitamins and supplements are crafted by health experts and manufactured in the USA with globally sourced ingredients. This supplement is non-GMO, free of major allergens, gluten-free, and manufactured in a GMP-certified facility to ensure purity, potency, and quality. It contains no animal-derived substances – making it a great option for vegans & vegetarians.
Snap’s plant-based kidney formula uses organic cranberry and botanical extracts for gentle daily kidney and urinary tract support.
Formulated with organic cranberry, grape seed extract, and other botanicals traditionally used for kidney wellness, this supplement takes a clean, plant-based approach. The 60 vegetarian capsules provide a 30-day supply. Snap manufactures in the USA in a GMP-certified facility, and the formula is non-GMO, allergen-free, gluten-free, and contains no animal-derived substances. The gentle formula is designed for daily use without harsh detox effects.
Pros:
100% plant-based and vegan-friendly
Organic cranberry for quality assurance
Gentle enough for daily long-term use
Cons:
Fewer total ingredients than PurePremium’s 21-in-1
30-day supply requires monthly reorders
Best for: Vegans and health-conscious individuals seeking a gentle, plant-based kidney supplement
4. Advanced Kidney Support Supplement – Best for Urinary Tract
Sale
Advanced Kidney Support Supplement – Kidney Cleanse Detox & Repair Cranberry Extract Capsules with Uva Ursi, Stinging Nettle & Astragalus for Kidney health – Urinary Tract Health – 60 Caps
ADVANCED KIDNEY CLEANSE & DETOX SUPPORT – Maintain optimal kidney function with this high-potency herbal kidney health supplement, designed to support natural detox, fluid balance & urinary tract health. A gentle yet effective bladder control supplements to help your kidneys function at their best.
URINARY TRACT & BLADDER WELLNESS – This kidney supplement is crafted with botanical extracts that help flush out impurities, support urinary flow, and maintain bladder health. Suitable bladder support for women & men, it’s a natural choice for promoting urinary balance.
NATURAL HERBAL BLEND FOR KIDNEY SUPPORT – Features a potent combination of astragalus, cranberry extract, uva ursi, stinging nettle, horsetail herb, java tea & chanca piedra capsules. These cranberry herbal supplements are traditionally used to assist with detox, promote kidney & urinary tract function.
USAGE INSTRUCTIONS & IMPORTANT GUIDELINES – Take one to two kidney restore uva ursi capsules daily with water to support kidney and urinary tract function. For long-term kidney health, use consistently and consult a doctor before prolonged use, especially if pregnant, nursing, or taking medications.
MADE IN THE USA WITH GLOBALLY SOURCED INGREDIENTS – Made in the USA in a GMP-compliant facility, this third-party tested nettle seeds for kidney cleanse & better bladder supplement provides purity, potency & safety. Formulated with non-GMO ingredients and free from artificial additives.
This kidney cleanse and detox formula pairs cranberry extract with uva ursi, stinging nettle, and astragalus for strong urinary tract support alongside kidney health.
The formula emphasizes both kidney cleansing and urinary tract protection with a targeted blend of cranberry extract capsules, uva ursi (bearberry) for antimicrobial support, stinging nettle for anti-inflammatory benefits, and astragalus for immune and kidney function. At 60 capsules per bottle, this supplement provides a full month of daily support. The combination of cranberry with uva ursi is particularly effective for urinary tract maintenance.
Pros:
Strong urinary tract focus with cranberry + uva ursi
Astragalus and nettle provide immune and anti-inflammatory support
Well-balanced formula for kidney cleanse and maintenance
Cons:
Standard Amazon brand — less established than specialty brands
May not be potent enough for significant kidney concerns
Best for: People who want combined kidney and urinary tract support in a single supplement
5. Organic Cranberry Pills 50:1 Concentrate – Best Cranberry Supplement
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Organic Cranberry Pills – 50:1 Concentrate Equals 25,000mg of Fresh Cranberries (Vegan) for Urinary Tract Health & Kidney Cleanse – Cranberry Pills for Women – UTI Support Supplement – 60 Capsules
Boost yourself with a berry blast: When it comes to supplements, more isn’t always better; but when it comes to cranberries, your body can use as much as you can give it. That’s why we’ve crammed the equivalent of 25,000mg of fresh, organic cranberries into just one vegan capsule. Whether you’re going on a kidney cleanse or want to maintain a healthy urinary tract, try Pure Co cranberry pills.
Certified organic cranberry concentrate: We’re on a mission to provide you the very best nutrients we can that’s why our organic cranberries are sourced from local USA and Canada farms, we’ve also taken the time and invested the money to bring you certified organic & non-GMO ingredients in every capsule of this widely acclaimed kidney health booster.
Made the right way in the USA: Our mission also extends to manufacturing our supplements to the highest possible standards. GMP-certified, our facility utilizes the most stringent quality control measures to ensure you’re getting the same healthy ingredients in every veggie capsule. Plus, none of our products contain: yeast, wheat, gluten, dairy, corn, soy, eggs, sugar, tree nuts, peanuts, fish, shellfish, or hydrogenated oils.
Only the best: When you take just one capsule, you’re getting a whopping 25,000mg equivalent of organic concentrated cranberry power. Even the vegan capsule we use are non-GMO, providing amazing cranberry concentrate pills.
Order today: Try a full bottle of our organic cranberry concentrate to experience the benefits of this highly regarded unity tract helper for yourself; Click add to cart today.
Each capsule delivers the equivalent of 25,000mg of fresh cranberries through a potent 50:1 concentration, making it one of the strongest cranberry supplements available.
Cranberry is the cornerstone ingredient for kidney and urinary tract health, and this organic formula maximizes cranberry’s benefits through a 50:1 extraction ratio. The vegan capsules provide highly concentrated proanthocyanidins (PACs), the active compounds in cranberry responsible for preventing bacterial adhesion in the urinary tract. Organic certification ensures clean sourcing without pesticides or synthetic additives.
Pros:
50:1 concentration — equivalent to 25,000mg fresh cranberries
Organic and vegan-certified
High PAC content for urinary tract protection
Cons:
Single-ingredient — doesn’t include kidney-specific herbs like astragalus
Best used as part of a broader kidney health regimen
Best for: Anyone wanting a pure, concentrated cranberry supplement for kidney and urinary support
6. Natural Cranberry Gummies – Best Gummies
Natural Cranberry Gummies for Women and Men – Extra Strength Delicious Antioxidant Cranberry Chews for Urinary Tract Health Kidney Support Bladder & Immune Health – Vegan Gluten & Gelatin Free – 60ct
TAKE URINARY HEALTH SERIOUSLY – Experience the power of a more natural dietary supplement like our cranberry gummies that have been expertly formulated to give you essential kidney and bladder support
BOOST YOUR BLADDER HEALTH – Cranberry concentrate has been known to help improve bladder health as well as enhance urinary tract health and provides much needed kidney support for men and women
A BOTTLE OF BENEFITS – Our gummies are packed with antioxidants that support joint health and womens health that can give you a gentle kidney cleanse with a formula that can improve your immune health
CRANBERRY CONCENTRATE – Cranberries are rich in antioxidants compared to other fruits which is why our cranberry gummies are the gummy of choice among adults who enjoy an overall health boost
NATURES CRAFT QUALITY – We believe in real ingredients for real results which is why our dietary supplements make use of plant-based ingredients that are non-GMO for your health and peace of mind
For those who dislike swallowing capsules, these extra-strength cranberry gummies deliver kidney-supporting antioxidants in a delicious chewable format.
These cranberry chews provide potent cranberry extract with antioxidant support for both men and women. The gummy format makes daily supplementation enjoyable and easy to maintain consistently. While gummies typically offer lower concentrations than capsules, these are formulated at extra strength to provide meaningful cranberry benefits for kidney and urinary tract health.
Pros:
Great-tasting gummy format for easy compliance
Suitable for men and women
Extra-strength cranberry extract
Cons:
Contains added sugars common in gummy supplements
Lower concentration per serving than capsule forms
Best for: People who have difficulty swallowing pills or prefer a more enjoyable supplement format
7. Extra Strength Tart Cherry Capsules – Best for Uric Acid Support
Extra Strength Tart Cherry Capsules – Tart Cherry Extract Capsules 7500mg for Uric Acid Cleanse for Gout & Kidneys Support – Fruit Extract Supplement for Urinary Tract Health & Joint Support – 240 Ct
POTENT URIC ACID & JOINT SUPPORT – Our extra strength tart cherry powder capsules offer a high-potency 7500mg equivalent dose of tart cherry extract, known to support joint health, uric acid cleanse, and post-workout recovery for men and women seeking optimal mobility and wellness.
FULL-SPECTRUM WELLNESS BENEFITS – Tart cherry concentrate is packed with nutrients and anthocyanins that help reduce oxidative stress, ease joint discomfort, support kidney and urinary tract function, and promote natural immune balance for better flexibility and endurance.
CLINICALLY STUDIED FRUIT EXTRACTS – Each serving contains cherry tart extract rich in polyphenols and flavonoids that work synergistically to flush excess uric acid, protect the kidneys, and combat free radicals that may lead to joint strain or discomfort.
HOW TO USE – Adults may take 2 tart cherry supplement capsules daily with a full glass of water, preferably with a meal. For ongoing support, use consistently for a minimum of 4–6 weeks. Consult a healthcare provider before use if pregnant, nursing, or managing a medical condition.
MADE IN THE USA WITH GLOBALLY SOURCED INGREDIENTS – Our uric acid supplement is manufactured in a GMP-certified facility. These cherry tart concentrate capsules are third-party tested, non-GMO, vegan-friendly, and free of gluten and artificial additives, providing a clean supplement.
Tart cherry extract at 7,500mg strength helps support healthy uric acid levels, reducing the burden on kidneys from uric acid processing.
High uric acid levels place significant strain on the kidneys and can contribute to kidney stone formation. This extra-strength tart cherry extract provides 7,500mg equivalent per serving, delivering powerful anthocyanins that support healthy uric acid metabolism. Tart cherry also offers potent anti-inflammatory and antioxidant benefits that complement overall kidney health. The capsule form provides higher potency than typical tart cherry gummies.
Pros:
7,500mg tart cherry extract for potent uric acid support
Rich in anthocyanins — powerful kidney-protective antioxidants
Supports both kidney health and joint comfort
Cons:
Primarily targets uric acid rather than comprehensive kidney function
Best used alongside a dedicated kidney supplement
Best for: People with uric acid concerns who want to reduce kidney strain from uric acid processing
8. Healthy Kidney Inc. Kidney Restore – Best Specialist Brand
Kidney Cleanse Detox & Repair – Formulated by Kidney Health Expert Living w/Transplant – US Made Kidneys Support Supplement, Detox, Flush – Renal Vitamins 60 Capsules
Our one-of-a-kind science-based supplement supports kidney health from multiple angles for max kidney support. you will not find this in other vitamins or supplements. Over 50,000 people have used Kidney Restore and reported good kidney health and it improved the quality of their lives! There is hope for supported kidneys. Let our specialty take your health to a new level!
The Probiotic microorganisms & FOS support kidneys by supporting natural elimination of bad stuff in the gut; this supports kidney health by allowing them to work less and rest. The delayed release sodium bicarb neutralizes renal acids and body junk, balances minerals and so much more. This is the most complete kidney supplement out there. Niacin to support phosphorus levels & heart health. Let Kidney Restore support your kidneys!
Support kidney health and overall function with our targeted blend of ingredients; safe to use with other supplements; manufactured and checked in cGMP registered facility, instructions on package to access eBook 2-Day Kidney clean up on how to best use Kidney Restore with a renal clean up diet. Product support by health coaches, but more importantly a real simple natural way to support kidneys without any negatives
Keep your kidney health to support function and increase flow; a weak kidney leads to low energy levels, appetite loss, etc., but you can support your kidney health starting today. Naturally support your kidney health without adverse effects and shock your professional on your next visit! To learn more keep reading, see the images and videos
Created by a naturopath and nutritionist, who has an active blog, you tube channel and who has personally gone through it all; risk nothing purchase with a 100% compensated if unhappy. Your kidneys need the proper support for the long term. Kidney Restore makes sure your kidneys have all the nutrition they need to support kidney health for years to come.
Created by a naturopath who personally experienced kidney health challenges, Kidney Restore targets five key areas of kidney support with a unique probiotic-enhanced formula.
Unlike most kidney supplements that rely solely on herbal blends, Kidney Restore includes niacin, sodium bicarbonate, and beneficial probiotics (Lactobacillus acidophilus and B. longum) alongside fructooligosaccharides (prebiotics). This formula addresses kidney detox, acid-base balance, and gut-kidney axis support. Created by Healthy Kidney Inc., a company dedicated exclusively to kidney health products, this supplement comes with access to health coaching and educational resources.
Pros:
Unique probiotic approach addresses the gut-kidney connection
Includes sodium bicarbonate for acid-base balance
Created by kidney health specialists with personal experience
Cons:
Different approach than traditional herbal kidney supplements
Higher price point than basic cranberry-based formulas
Best for: People seeking a specialist-formulated kidney supplement that goes beyond standard herbal blends
How to Choose the Best Kidney Health Supplement
Effective kidney supplements typically contain cranberry extract (for urinary tract protection and antioxidant support), astragalus root (which research suggests may help protect kidney cells), and supportive herbs like nettle leaf, uva ursi, and juniper berry. Look for cranberry products with high PAC (proanthocyanidin) content and astragalus standardized to polysaccharide content for optimal potency.
Recommended daily intake varies by ingredient. Cranberry extract is commonly dosed at 500-1,500mg daily (or the fresh fruit equivalent listed on the label). Astragalus is typically used at 500-1,000mg daily. For products with proprietary blends, look for total blend weights of at least 500mg per serving to ensure meaningful amounts of active ingredients.
Capsules offer the best bioavailability for kidney supplements, though gummies provide a more enjoyable option for daily compliance. Softgels work well for oil-based kidney nutrients. Avoid supplements with excessive fillers, artificial colors, or high sodium content — the kidneys are responsible for processing these additives, which defeats the purpose of kidney support.
Quality certifications matter significantly for kidney supplements. Choose products manufactured in GMP-certified facilities, and prioritize organic ingredients when available. Third-party testing from NSF, USP, or independent labs provides additional quality assurance. People with existing kidney conditions should always consult a nephrologist before starting any supplement.
Frequently Asked Questions
What supplements are best for kidney health?
The most beneficial kidney supplements contain cranberry extract (for urinary tract health and antioxidant protection), astragalus root (for kidney cell protection), stinging nettle (anti-inflammatory support), and uva ursi (antimicrobial properties). Omega-3 fatty acids, vitamin D, and B vitamins also support kidney function. A comprehensive kidney formula combining multiple ingredients typically provides the broadest support.
How much cranberry should I take for kidney health?
Most kidney health supplements provide 500-1,500mg of cranberry extract daily, with concentrated forms (such as 50:1 extracts) delivering the equivalent of 12,500-25,000mg of fresh cranberries. The key active compounds are proanthocyanidins (PACs), with a minimum of 36mg PACs daily recommended for urinary tract maintenance. Higher doses may be beneficial during periods of increased urinary tract concern.
When is the best time to take kidney supplements?
Kidney supplements are best taken with a meal to improve absorption and reduce the chance of stomach upset. Morning or early afternoon is ideal, as this aligns with the body’s peak metabolic activity. For cranberry-based supplements, consistent daily timing helps maintain steady levels of protective compounds in the urinary tract. Stay well-hydrated throughout the day to support kidney function alongside supplementation.
Are there side effects of kidney supplements?
Most kidney supplements are well-tolerated when taken as directed. Cranberry may cause mild stomach upset in some people and can interact with blood-thinning medications like warfarin. Astragalus may affect blood sugar levels and immune function. People with kidney disease, kidney stones, or those taking prescription medications should consult a healthcare provider before starting any kidney supplement to avoid potential interactions.
Can kidney supplements help prevent kidney stones?
Certain supplements may help reduce kidney stone risk. Cranberry extract helps prevent urinary tract infections that can contribute to stone formation. Tart cherry supports healthy uric acid levels, reducing the risk of uric acid stones. Chanca piedra (stone breaker) has traditional use for kidney stone prevention. However, staying well-hydrated and maintaining a balanced diet remain the most important factors in kidney stone prevention.
How long does it take for kidney supplements to work?
Kidney supplements typically require 2-4 weeks of consistent use before noticeable benefits emerge. Urinary tract improvements from cranberry may be felt sooner, often within 1-2 weeks. For general kidney health maintenance, plan on at least 30 days of daily supplementation. Long-term, consistent use provides the most significant kidney-protective benefits, as these supplements work best as part of an ongoing health regimen.