Heart health becomes increasingly important with age, as cardiovascular disease remains the leading cause of death among older adults. The right supplements can support healthy blood pressure, cholesterol levels, arterial flexibility, and overall cardiac function. From CoQ10 and omega-3s to nattokinase and beet root, these are the best heart supplements formulated with seniors in mind.
Quick Comparison
Product
Key Ingredient
Form
Best For
Rating
PurePremium Blood Pressure Support
Hawthorn, Hibiscus, Garlic
Capsules
Best Overall
4.8
Lunakai Nattokinase
Nattokinase 8,000 FU
Capsules
Best for Circulation
4.7
Lunakai CoQ10 Gummies
CoQ10 200mg
Gummies
Best CoQ10
4.7
PurePremium Beet Root Capsules
Beetroot, Hawthorn, CoQ10
Capsules
Best Multi-Ingredient
4.6
Effective Nutra Resveratrol Gummies
Resveratrol 1,500mg
Gummies
Best Antioxidant
4.6
Qunol Ultra CoQ10
CoQ10 100mg
Softgels
Best for Statin Users
4.7
Nordic Naturals Omega-3
EPA/DHA Fish Oil
Softgels
Best Omega-3
4.8
1. PurePremium Blood Pressure Support – Best Overall
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PurePremium Blood Pressure Supplements with Hawthorn Berry, Hibiscus, Garlic & Vitamin B12- Nitric Oxide Supplement for Normal Heart Health, Circulation Health & Blood Pressure Support – 90ct
NORMAL BLOOD PRESSURE SUPPORT: Support normal nitric oxide and blood pressure levels already within the normal range with our advanced herbal formula. Crafted from the finest ingredients, it contains potent vitamins for your wellbeing. Take 1 capsule daily of our natural blood pressure support supplement.
NORMAL NITRIC OXIDE SUPPORT: Unlike other nitric oxide supplements for men, PurePremium offers highly absorbable, fast-acting formula. This makes our blood pressure support supplement a perfect nitric oxide supplement for supporting normal cardiovascular health.
ALL IN ONE FORMULA: Experience a blend of nutrients in our blood pressure supplements, featuring, hawthorn berry, hibiscus, garlic extract, olive leaf, buchu leaf, uva ursi, juniper berry, green tea, vitamin C, niacin, vitamin B6, folate, and vitamin B12.
USA-MADE, LAB TESTED: PurePremium Blood Pressure Support supplement is manufactured in a USA-based facility with globally sourced ingredients. Each batch of our nitric oxide supplement is tested by a third-party lab to ensure safety.
CAUTION: CONSULT A HEALTHCARE PROFESSIONAL BEFORE USE: Individuals with pre-existing medical conditions or those taking prescription medications should consult with a healthcare professional before using this supplement. Follow recommended dosage instructions. Seek medical advice for adverse effects.
A comprehensive multi-ingredient formula combining hawthorn berry, hibiscus, garlic, and vitamin B12 for broad cardiovascular support.
PurePremium’s Blood Pressure Support is a powerhouse formula targeting multiple aspects of heart health simultaneously. It combines hawthorn berry extract — one of the most well-researched botanicals for cardiovascular support — with hibiscus, garlic, and olive leaf extract. The formula also includes vitamin B12 and a nitric oxide-supporting blend to promote healthy blood flow and arterial flexibility. This is an ideal all-in-one supplement for seniors who want comprehensive heart support without taking multiple separate products.
Pros:
Multi-ingredient formula covers blood pressure, circulation, and cholesterol
Includes hawthorn berry, one of the best-studied heart botanicals
Made in the USA in a GMP-certified facility
Cons:
Multiple capsules per serving
Those on blood pressure medication should consult a doctor first
Best for: Seniors looking for a comprehensive, all-in-one heart health supplement
2. Lunakai Nattokinase Supplement – Best for Circulation
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Lunakai USA Made Nattokinase Supplement – 400mg Natto Enzyme, 8000 FU per Serving – Heart & Circulation Support – Non-GMO, 60ct, 4000 FU Capsule
Supports Circulation – Each serving delivers 8000 FU of nattokinase, traditionally sourced to assist in supporting normal blood flow.
Natural Heart Support – Our nattokinase supplement is formulated to complement daily routines focused on overall heart wellness support.
Clean & Simple Ingredients – Each capsule contains 200mg of nattokinase enzyme, delivering 4000 FU, sourced from fermented natto with no artificial flavors or additives.
Vegan-Friendly Formula – Our nattokinase supplement is 100% vegan and plant-based, with no animal-derived ingredients or gelatin.
Made in the USA – Manufactured in the United States in a facility that follows GMP (Good Manufacturing Practices) for quality and consistency.
A potent 8,000 FU nattokinase supplement supporting healthy blood flow and circulatory function.
Nattokinase is a fibrinolytic enzyme derived from natto (fermented soybeans) that has been extensively studied for its ability to support healthy circulation and blood viscosity. Lunakai’s formula delivers 400mg of nattokinase at 8,000 fibrinolytic units (FU) per serving — a clinically meaningful dose. This is particularly relevant for seniors, as circulatory efficiency naturally declines with age. The supplement is USA-manufactured, non-GMO, and free from common allergens.
Pros:
8,000 FU per serving — clinically relevant nattokinase dose
Supports healthy circulation and blood flow
Clean formula with no artificial additives
Cons:
Should not be combined with blood-thinning medications without medical guidance
Derived from soy — not suitable for soy-allergic individuals
Best for: Seniors focused on improving circulation and maintaining healthy blood flow
3. Lunakai CoQ10 Gummies – Best CoQ10
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Lunakai USA Made CoQ10 Gummies for Adults 200mg – Coenzyme Q10 for Heart Health, Cellular Energy & Aging Support – Non-GMO, Vegan, 60ct
CoQ10 Gummies for Heart Health Support – Each orange-flavored gummy contains 200mg of CoQ10 to support heart health and daily wellness.
Supports Cellular Energy – These coq 10 gummies for adults support the body convert nutrients into energy at the cellular level to stay active and energized.
Daily Antioxidant Support – CoQ10 may contribute to your body’s natural antioxidant processes, helping to support overall cellular wellness.
Q10 Vitamins for Women & Men – Specially designed for adult wellness, these co q 10 gummies are suitable for both men and women seeking daily vitality.
Vegan CoQ10 Gummies – Made with non-GMO, plant-based ingredients and no gelatin, these vegan coq10 gummies fit into a variety of dietary lifestyles.
A tasty 200mg CoQ10 gummy designed for heart health, cellular energy, and antioxidant protection.
CoQ10 levels naturally decline with age, and this decline is accelerated by statin medications. Lunakai’s CoQ10 gummies provide 200mg of Coenzyme Q10 per serving in an easy-to-chew format that is particularly appealing for seniors who have difficulty swallowing capsules. CoQ10 plays a critical role in cellular energy production within the mitochondria and acts as a powerful antioxidant to protect cardiovascular tissues from oxidative damage. Made in the USA with no artificial colors or flavors.
Pros:
200mg CoQ10 per serving — well-researched dose for heart support
Gummy format is easy to take for seniors
Supports both heart health and cellular energy
Cons:
Contains added sugars
Ubiquinone form rather than ubiquinol (the active form)
Best for: Seniors who want CoQ10 support in a convenient, chewable gummy
4. PurePremium Beet Root Capsules – Best Multi-Ingredient
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PurePremium Beet Root Capsules – 3-in-1 Blood Pressure Supplements with Beets, CoQ10 & Grapeseed – Beetroot Capsules Nitric Oxide Supplement for Normal Heart Health & Circulation Health – 60ct
3-IN-1 BLOOD PRESSURE SUPPORT FORMULA: Our beets supplements combine the power of Beetroot, CoQ10, and Grape Seed Extract to help support blood pressure levels already within the normal range and normal cardiovascular wellness.*
HEALTHY CIRCULATION & NITRIC OXIDE SUPPORT: Beet root supplements naturally support nitric oxide production, normal circulation, and nutrient delivery throughout the body—helping you feel energized and balanced every day.*
NORMAL HEART HEALTH SUPPLEMENTS: Formulated with CoQ10, a compound essential for normal energy production in heart cells, this supplement supports cardiovascular vitality and helps maintain healthy heart function as part of your daily routine.*
GRAPE SEED FOR ANTIOXIDANT & VASCULAR SUPPORT: Grape Seed Extract provides natural antioxidants that help protect against oxidative stress and support the integrity of healthy blood vessels—supporting normal circulation and heart function.*
PUREPREMIUM QUALITY YOU CAN TRUST: Made in the USA from globally sourced ingredients under strict GMP standards. 3rd-party lab-tested, Non-GMO, plant-based, and free from gluten, soy, dairy, and artificial sweeteners—for purity and potency.*
A 3-in-1 blood pressure formula combining beet root with CoQ10 and grapeseed extract for synergistic heart support.
This PurePremium formula takes a multi-angle approach to cardiovascular health by combining organic beet root powder with CoQ10 and grapeseed extract. Beet root is a natural source of dietary nitrates that convert to nitric oxide in the body, promoting vasodilation and healthy blood pressure. CoQ10 adds cellular energy and antioxidant support, while grapeseed extract contributes polyphenols that protect blood vessels. The capsule format delivers all three ingredients in a single convenient serving.
Pros:
Three synergistic heart-health ingredients in one capsule
Beet root supports natural nitric oxide production
GMP-certified and made in the USA
Cons:
Individual ingredient doses may be lower than standalone supplements
Beet root may cause harmless red discoloration of urine
Best for: Seniors who want a convenient multi-ingredient formula for blood pressure and heart health
5. Effective Nutra Resveratrol Gummies – Best Antioxidant
EFFECTIVE NUTRA Resveratrol Gummies 1500mg | Sugar-Free Supplement for Antioxidant Support, Immunity, Heart Health, and Brain Function | 45-Day Supply, Natural Berry Flavor, Made in USA (90 Count)
#1 RESVERATROL GUMMY: Our sugar free Resveratrol gummies taste great & go down easy. Each serving is packed with 1500mg. 90 Gummies in a bottle for the best value out there!*
GET ALL THE BENEFITS: Packed in a potent blend that may promote Heart Health, Immune System Support, Brain Function, Stress Relief, and Healthy Aging.*
ANTIOXIDANT SUPPORT: Each gummy is loaded with Resveratrol to fight oxidative stress and promote vitality.*
HEALTHY & DELICIOUS: Our Resveratrol gummies are sugar free, naturally raspberry watermelon flavored. No artificial colors or flavors!*
EFFECTIVE NUTRA EXCELLENCE: Vegan, Gluten-Free, Non-GMO, 3rd Party Tested, GMP Certified, Made in USA with Global Ingredients. Quality you can trust!*
A high-potency 1,500mg resveratrol gummy delivering powerful antioxidant and cardiovascular protection.
Resveratrol — the polyphenol found in red wine and grapes — has been extensively studied for its cardiovascular benefits, including support for healthy cholesterol levels, arterial flexibility, and reduced oxidative stress. Effective Nutra’s sugar-free gummies deliver 1,500mg of resveratrol per serving, making this one of the most potent resveratrol supplements available in a gummy format. The sugar-free formula is particularly suitable for seniors managing blood sugar levels.
Pros:
1,500mg per serving — high-potency resveratrol dose
Sugar-free formula suitable for diabetic or pre-diabetic seniors
Powerful antioxidant protection for cardiovascular tissues
Cons:
Resveratrol bioavailability can be limited without fat-based delivery
Gummy format may not appeal to all users
Best for: Seniors focused on antioxidant protection and longevity-oriented heart health
6. Effective Nutra Berberine Gummies – Best for Cholesterol
Effective Nutra Berberine Gummies with Ceylon Cinnamon | Sugar-Free Supplement 1200mg for Blood Sugar Support, Heart Health, Energy | 45-Day Supply, Natural Berry Flavor, Made in USA (90 Count)
Premium Berberine with Ceylon Cinnamon: Crafted with high-quality berberine and premium Ceylon cinnamon, our gummies deliver a potent blend to help you feel your best every day. These ingredients are thoughtfully combined to support energy balance, overall wellness, and a healthy lifestyle. Perfect for both men and women seeking a convenient health solution.*
Metabolism & Heart Wellness Support: Formulated to help maintain healthy metabolic function and promote heart wellness, these gummies offer a clean, effective, and convenient way to support your overall health. Enjoy the benefits of berberine and Ceylon cinnamon in a naturally delicious format.*
Natural Energy & Vitality in Every Bite: Experience the natural benefits of berberine in a delicious and sugar-free gummy form. Designed to support an active, vibrant lifestyle, these gummies make it simple to incorporate essential wellness support into your daily routine.*
Convenient & Easy-to-Take Gummies: No more dealing with messy powders or hard-to-swallow capsules! Our naturally flavored, sugar-free gummies are designed for convenience and taste, making it easier than ever to enjoy the benefits of berberine. Simply take 2 gummies daily or as recommended by your healthcare professional. Each bottle includes 90 gummies, providing a 45-day supply.*
For Every Lifestyle: Vegan, Non-GMO, Gluten-Free, Dairy-Free, Soy-Free, Gelatin-Free, and Pectin-Based. Produced in a GMP-certified facility and rigorously third-party tested, these gummies are crafted with clean ingredients to fit into any wellness routine.*
A 1,200mg berberine formula with Ceylon cinnamon for cardiovascular and metabolic health support.
Berberine has gained significant attention for its ability to support healthy cholesterol levels, blood sugar regulation, and cardiovascular function — often compared to certain prescription medications in clinical studies. Effective Nutra combines 1,200mg of berberine with Ceylon cinnamon for synergistic metabolic support. The sugar-free gummy format makes this supplement accessible for seniors who prefer chewable options. Berberine activates AMPK, a metabolic master switch involved in lipid metabolism and glucose regulation.
Pros:
1,200mg berberine — clinically studied dose for cholesterol and blood sugar
Ceylon cinnamon adds complementary metabolic support
Sugar-free gummy format
Cons:
May interact with diabetes and cholesterol medications
Berberine can cause digestive discomfort in some users
Best for: Seniors managing cholesterol and blood sugar who want a natural support supplement
7. Qunol Ultra CoQ10 – Best for Statin Users
No products found.
A water and fat-soluble CoQ10 with enhanced absorption, specifically designed to replenish CoQ10 depleted by statin drugs.
Qunol Ultra CoQ10 uses patented water-soluble technology to deliver 100mg of CoQ10 with up to 3x better absorption than standard CoQ10 supplements. This is particularly important for seniors taking statin medications, which are known to deplete the body’s natural CoQ10 levels. The softgel format includes natural ingredients to enhance bioavailability without requiring food for absorption. Qunol is the #1 cardiologist-recommended form of CoQ10.
Pros:
Patented water-soluble formula for 3x better absorption
Specifically beneficial for statin medication users
#1 cardiologist-recommended CoQ10 brand
Cons:
100mg dose — some seniors may need a higher amount
Softgels contain bovine gelatin (not vegan)
Best for: Seniors on statin medications who need highly absorbable CoQ10 replenishment
8. Nordic Naturals Ultimate Omega – Best Omega-3
No products found.
A premium triglyceride-form fish oil delivering 1,280mg of EPA/DHA per serving for comprehensive heart and brain support.
Omega-3 fatty acids are among the most well-researched nutrients for heart health, with strong evidence supporting their role in maintaining healthy triglyceride levels, blood pressure, and arterial function. Nordic Naturals Ultimate Omega delivers 1,280mg of combined EPA and DHA in the superior triglyceride form for maximum absorption. The product is third-party tested for purity, molecularly distilled to remove heavy metals and contaminants, and certified by Friend of the Sea for sustainability. Each serving provides a clinically meaningful dose for cardiovascular support.
Pros:
1,280mg EPA/DHA in superior triglyceride form
Third-party tested for purity and potency
Sustainably sourced and Friend of the Sea certified
Cons:
Premium price point
Fish oil may cause fishy aftertaste in some users
Best for: Seniors who want a premium, purity-tested omega-3 for comprehensive heart and brain support
9. Luma Nutrition Nattokinase – Best Budget Nattokinase
Luma Nutrition Nattokinase Supplement – Natto 4000 FU Per Serving, Premium Heart Health Support – Vegan & Gluten Free – 60 Capsules – Made in USA
Premium Natto Extract: Luma Nutrition’s powerful nattokinase supplement boasts superior quality and a powerful dosage of Nattokinase 4000 fu, twice as strong as other nattokinase 2000 fu products. These effective Nattokinase powder capsules promote healthy blood flow and circulation, supporting cardiovascular function and overall heart health.
Natural Heart Support: Nattokinase is an enzyme extracted from natto, a traditional Japanese fermented soybean dish. It’s renowned for its fibrinolytic properties, meaning it helps break down fibrin, a protein involved in restricted blood flow. Without the presence of Serrapeptase or Lumbrokinase, this supplement works for vegan or gluten-free diets.
30 Day Supply: Each bottle of Luma’s nattokinase supplement organic lasts for a month to maintain optimal freshness and provides natural heart health support. This nattokinase supplement for men and women makes the perfect monthly subscription.
3rd Party Tested: All of our products are 3rd party tested for purity and quality. Our Nattokinase is made in the USA in our fully certified facility. Non-gmo and the highest quality.
Proudly USA: All Luma Nutrition supplements are manufactured in GMP certified facilities in the United States to ensure product safety and quality is always upheld. Certificed by NSF December 2023. We are veteran owned and operated.
An affordable nattokinase supplement delivering 4,000 FU per serving for daily circulatory support.
Luma Nutrition’s Nattokinase provides 4,000 FU per serving at a significantly lower price point than premium alternatives. While the dose is lower than some high-potency options, 4,000 FU is still within the range used in clinical research for circulatory support. The capsule format is straightforward and easy to incorporate into a daily routine. This is a solid entry-level nattokinase option for seniors exploring circulatory support supplementation.
Pros:
Affordable price point for daily nattokinase supplementation
4,000 FU per serving — within clinically studied range
Simple, clean formula
Cons:
Lower potency than premium 8,000-10,000 FU options
Less brand recognition than category leaders
Best for: Budget-conscious seniors who want to try nattokinase for circulatory support
How to Choose the Best Heart Supplement for Seniors
The most effective heart supplements for seniors target specific cardiovascular concerns. CoQ10 is essential for anyone over 60, as natural production declines significantly with age and is further depleted by statin medications. Look for ubiquinol (the active, reduced form) or formulas with enhanced absorption technology for maximum benefit. Doses of 100-200mg daily are most commonly recommended.
Omega-3 fatty acids (EPA and DHA) have the strongest evidence base for cardiovascular support, with research showing benefits for triglyceride levels, blood pressure, and arterial inflammation. Choose a fish oil in triglyceride form rather than ethyl ester for better absorption, and aim for a combined EPA/DHA dose of at least 1,000mg daily.
Nattokinase is gaining recognition for circulatory support, with research suggesting it may help maintain healthy blood viscosity and promote arterial health. However, it should not be combined with anticoagulant medications without medical supervision. Hawthorn berry and beet root are additional evidence-based botanicals for blood pressure and vascular health.
Always consult with a healthcare provider before starting any heart supplement, especially if you are taking prescription medications for blood pressure, cholesterol, or blood clotting. Drug-supplement interactions are a real concern for seniors on multiple medications.
Frequently Asked Questions
What is the best supplement for heart health in seniors?
CoQ10 and omega-3 fatty acids have the strongest research backing for senior heart health. CoQ10 supports cellular energy production in heart muscle cells and protects against oxidative damage, while omega-3s help maintain healthy triglyceride levels and arterial function. Many cardiologists recommend both as part of a comprehensive heart health regimen.
Should seniors take CoQ10?
Yes, CoQ10 is one of the most recommended supplements for seniors. Natural CoQ10 production declines significantly after age 40, and statin medications further deplete levels. Supplementing with 100-200mg of CoQ10 daily can support heart function, reduce fatigue, and provide antioxidant protection for cardiovascular tissues.
Is nattokinase safe for seniors?
Nattokinase is generally considered safe for healthy seniors at standard doses of 2,000-8,000 FU daily. However, it has blood-thinning properties and should not be taken alongside anticoagulant medications like warfarin, aspirin, or other blood thinners without medical supervision. Seniors should consult their doctor before starting nattokinase.
How much omega-3 should seniors take daily?
Most health organizations recommend 1,000-2,000mg of combined EPA and DHA daily for cardiovascular benefit. Seniors with elevated triglycerides may benefit from higher doses of 2,000-4,000mg under medical guidance. Choose a triglyceride-form fish oil or algae-based omega-3 for optimal absorption.
Can heart supplements replace medications?
Heart supplements should complement — not replace — prescribed cardiovascular medications. While supplements like CoQ10, omega-3s, and berberine have demonstrated cardiovascular benefits in clinical research, they are not substitutes for prescription drugs treating diagnosed conditions like hypertension, high cholesterol, or heart failure. Always work with your healthcare provider when considering changes to your medication regimen.
When should seniors take heart supplements?
Fat-soluble supplements like CoQ10 and omega-3s are best absorbed when taken with a meal containing dietary fat. Nattokinase is often recommended on an empty stomach for optimal enzymatic activity. Taking heart supplements at a consistent time each day helps establish a routine and supports steady blood levels of the active compounds.