Small Intestinal Bacterial Overgrowth (SIBO) occurs when excessive bacteria colonize the small intestine, causing bloating, gas, abdominal pain, and nutrient malabsorption. While antibiotics like rifaximin are standard treatments, herbal antimicrobials — including berberine, oregano oil, allicin, and peppermint oil — have been shown in research to be comparably effective. Here are the best supplements for managing SIBO naturally.
Quick Comparison
Product
Key Ingredient
Form
Best For
Rating
SIBO | IBS Relief
Peppermint, S. boulardii, Probiotics
Delayed-Release Capsules
Overall SIBO relief
9.5/10
Integrative Therapeutics Berberine Complex
Berberine HCl
Capsules
Hydrogen-dominant SIBO
9.4/10
Atrantil Digestive Supplement
Quebracho, Peppermint, Horse Chestnut
Capsules
Methane-dominant SIBO/bloating
9.3/10
Allimax Pro 450mg Allicin
Stabilized Allicin
Capsules
Methane SIBO antimicrobial
9.2/10
Biotics Research Dysbiocide
Multi-herbal antimicrobial
Capsules
Practitioner-guided protocols
9.1/10
Integrative Therapeutics Peppermint Oil
Enteric-coated peppermint oil
Softgels
Symptom relief (bloating/gas)
9.0/10
BioSchwartz Prebiotics & Probiotics
Multi-strain probiotics
Capsules
Post-treatment gut restoration
8.8/10
1. SIBO | IBS Relief – Best Overall
SIBO | IBS Relief (Clinical Grade Treatment) Bloating, Diarrhea, Leaky Gut, Gas | Delayed Release Peppermint | Supplement Effective On Irritable Bowel Syndrome & Small Intestine Bacteria Overgrowth
Improve abdominal pain. Reduce bloating. Stimulate gut recovery.
Clinically studied ingredients that are safe for sufferers of SIBO and IBS.
Safe with low FODMAP and elemental diets. Safe with antimicrobrials, berberine, and Quebracho products.
Gluten Free – Vegan – Non-GMO – GMP – Made In The USA: DR Caps patented capsule technology delivers the ingredients intact for maximum potency.
Effective against diarrhea and constipation.
This clinical-grade formula is specifically designed for SIBO and IBS sufferers, combining delayed-release peppermint with targeted probiotics for comprehensive symptom relief.
The formula includes peppermint leaf extract, Saccharomyces boulardii, Lactobacillus acidophilus, Lactobacillus plantarum, and Bifidobacterium lactis in DR Caps patented delayed-release capsules that deliver ingredients intact past the stomach. The product is vegan, non-GMO, gluten-free, and GMP-certified. It is designed to be safe alongside low FODMAP and elemental diets, and compatible with antimicrobials and berberine protocols. The delayed-release technology is a major advantage for SIBO sufferers, as standard capsules often break down before reaching the small intestine where they’re needed most.
Pros:
Specifically formulated for SIBO and IBS
Delayed-release capsules deliver ingredients to the small intestine
Compatible with low FODMAP diets and antimicrobial protocols
Cons:
Not a standalone treatment — works best as part of a broader protocol
May not be sufficient for severe SIBO cases
Best for: Anyone seeking targeted SIBO symptom relief from a product designed specifically for small intestinal bacterial overgrowth.
2. Integrative Therapeutics Berberine Complex – Best for Hydrogen-Dominant SIBO
No products found.
Berberine is one of the most well-researched herbal antimicrobials for SIBO, and Integrative Therapeutics delivers a professional-grade formula trusted by practitioners worldwide.
Each capsule contains berberine HCl derived from Oregon grape, barberry, and goldenseal — traditionally used herbs with potent antibacterial properties. Research has shown berberine to be particularly effective against hydrogen-producing bacteria in the small intestine, making it a first-line herbal option for hydrogen-dominant SIBO. Integrative Therapeutics is a practitioner-grade brand distributed primarily through healthcare professionals, which speaks to its quality and formulation integrity. For those also dealing with digestive enzyme insufficiency, pairing berberine with a quality probiotic after the treatment phase can help restore microbial balance.
Pros:
Research-backed for hydrogen-dominant SIBO treatment
Practitioner-grade quality and formulation
Combines well with other antimicrobials in SIBO protocols
Cons:
Can cause diarrhea at higher doses in sensitive individuals
Should be used under practitioner guidance for proper dosing
Best for: Those with hydrogen-dominant SIBO who need a research-backed herbal antimicrobial as part of a structured treatment protocol.
3. Atrantil – Best for Methane-Dominant SIBO & Bloating
Nutra Disc & Joint Support Supplement – Clinically Formulated Restorative Cartilage Ligament and Tendon Supplement with Patented Meriva Curcumin & Glucosamine and Chondroitin for Adults – 90 Servings
Professional Formula: We are proud to offer our one of a kind soft tissue and joint supplements for men and women featuring the reparative Z-Pro Enzyme blend with proprietary proteolytic Serrazimes
Elevate your Comfort: Feel the Nutra Disc difference with our joint tendon and ligament supplements based on clinical studies showing the positive effects of protease enzymes for speeding up recovery
Anabolic Advantage: Unlike generic ligament and tendon supplements for men & women our caps were specifically made for practitioners so you can rest assured you’re getting professional grade products
Trusted Name Since 1924: Anabolic Laboratories has been committed to providing the highest quality nutritional products for 100 years and counting including our glucosamine chondroitin capsules
Guaranteed Potent and Pure: You can rest assured knowing you have a premium product with Anabolic Labs as all of our supplements are cGMP made in our NPA and FDA inspected American labs
Atrantil is a breakthrough botanical supplement that specifically targets methane-producing archaea in the gut — the organisms responsible for methane-dominant SIBO (now called IMO).
The formula combines three botanicals: M. balsamea Willd extract (peppermint) to calm the small bowel, quebracho extract to soak up hydrogen that feeds methane producers, and horse chestnut (conker tree) extract to eliminate the archaea themselves. This three-pronged mechanism makes Atrantil uniquely effective for methane SIBO, which is notoriously harder to treat than hydrogen-dominant forms. The product has been clinically studied and is frequently recommended by SIBO specialists like Dr. Nirala Jacobi and Dr. Mark Pimentel’s peers. Each bottle contains 90 capsules for a 30-day supply at the maintenance dose.
Pros:
Specifically targets methane-producing archaea
Clinically studied three-botanical formula
Frequently recommended by leading SIBO specialists
Cons:
Higher price point than single-ingredient antimicrobials
May require several weeks for noticeable improvement
Best for: Those with methane-dominant SIBO (IMO) characterized by bloating and constipation who need a targeted antimicrobial for archaea.
4. Allimax Pro 450mg Allicin – Best Allicin for SIBO
No products found.
Allimax Pro delivers 450mg of real, stabilized allicin per capsule — not just garlic extract — making it the most potent allicin supplement available for SIBO treatment.
Unlike standard garlic supplements that contain alliin (a precursor), Allimax uses a patented process to deliver actual bioactive allicin that’s immediately available for absorption. Research supports allicin’s effectiveness against methane-producing microbes, and it’s commonly paired with berberine, neem, or oregano oil in SIBO treatment protocols. Each bottle contains 100 capsules. The product is suitable for those on low FODMAP diets since the allicin extract doesn’t contain the fructans that make whole garlic problematic for SIBO patients.
Pros:
Contains real, stabilized allicin — not just garlic extract
Potent 450mg dose per capsule
Safe for low FODMAP diets (no fructans)
Cons:
May cause garlic breath or body odor
Premium pricing for the patented allicin extraction process
Best for: SIBO patients who need potent allicin as part of a multi-herb antimicrobial protocol, especially for methane-dominant forms.
5. Biotics Research Dysbiocide – Best Multi-Herb SIBO Formula
Source Naturals L-Tryptophan, for Mood, Relaxation, and Sleep*, 500mg – 120 Capsules
The essential amino acid l-tryptophan helps support relaxation, restful sleep, and positive mood.*
l-Tryptophan also supports immune functions because it is the body’s precursor to the kynurenines that regulate immunity.
Suggested Use: 1 capsule three times daily, between meals and preferably with fruit juice. To support restful sleep, take an additional 3 capsules before bed.*
Over 40 Years of Trust. Source Naturals was created in 1982 by CEO Ira Goldberg to support everyone’s potential to enjoy optimal health.
Manufactured in the USA. Manufactured in Scots Valley, CA, under the Good Manufacturing Practices (cGMPs) established by the US Food and Drug Administration (FDA).
Dysbiocide is a professional-grade multi-herbal antimicrobial that combines several SIBO-targeting botanicals into a single practitioner-trusted formula.
This broad-spectrum herbal formula includes stemona, artemisia, brucea, and other botanical extracts traditionally used to address intestinal dysbiosis. Biotics Research is one of the most respected practitioner-only brands, and Dysbiocide is frequently included in SIBO treatment protocols alongside their companion product FC-Cidal (which contains French tarragon and other antimicrobials). The 120-capsule bottle provides a 30-day supply at the standard dosing of 4 capsules daily. This is the type of product commonly recommended by naturopathic doctors and functional medicine practitioners who specialize in SIBO treatment.
Pros:
Multi-herbal formula addresses multiple bacterial strains
Practitioner-grade quality from a respected clinical brand
Well-established track record in SIBO treatment protocols
Cons:
Best used under practitioner guidance for proper protocol design
Higher price point than single-ingredient options
Best for: Those working with a healthcare practitioner on a comprehensive SIBO elimination protocol who need a professional-grade multi-herb antimicrobial.
6. Integrative Therapeutics Peppermint Oil – Best for SIBO Symptom Relief
No products found.
Enteric-coated peppermint oil provides fast-acting relief from SIBO symptoms like bloating, gas, and abdominal pain while also offering mild antimicrobial benefits.
Each softgel delivers 200mg of enteric-coated peppermint oil that bypasses the stomach and releases in the small intestine where SIBO occurs. The enteric coating is essential — without it, peppermint oil can cause heartburn and reflux. Research supports peppermint oil’s antimicrobial properties against certain bacteria, and one case study showed improvement in hydrogen levels and symptoms in a SIBO patient using enteric-coated peppermint oil. Integrative Therapeutics manufactures this in GMP-certified facilities. For additional digestive support, consider pairing with a probiotic for bloating after completing an antimicrobial protocol.
Pros:
Enteric coating ensures delivery to the small intestine
Provides fast symptom relief for bloating and gas
Mild antimicrobial properties complement other SIBO treatments
Cons:
Not potent enough as a standalone SIBO treatment
May cause menthol-related side effects in sensitive individuals
Best for: SIBO sufferers who need symptom relief alongside their antimicrobial protocol, especially for bloating and abdominal discomfort.
7. Metagenics Candibactin-AR – Best Oregano Oil Formula for SIBO
No products found.
Candibactin-AR delivers concentrated oregano oil alongside thyme and other botanicals in a formula specifically used in SIBO clinical research.
This professional-grade supplement contains essential oils of oregano, thyme, and lemon balm — all with documented antimicrobial activity against intestinal bacteria. The oregano oil provides carvacrol and thymol, which kill bacteria by disrupting cell membranes while leaving beneficial Lactobacillus and Bifidobacterium strains relatively unharmed. Candibactin-AR is commonly paired with Candibactin-BR (a berberine formula) in what’s become one of the most widely used herbal SIBO treatment protocols in functional medicine. The famous Johns Hopkins study that compared herbal antibiotics to rifaximin used this exact combination and found comparable effectiveness.
Pros:
Used in the landmark Johns Hopkins SIBO herbal antibiotics study
Multi-herb formula with oregano, thyme, and lemon balm
Selectively targets harmful bacteria while sparing beneficial strains
Cons:
Best results when paired with Candibactin-BR (additional cost)
Practitioner-grade product with limited retail availability
Best for: Those following evidence-based herbal SIBO protocols, particularly when paired with a berberine formula for comprehensive antimicrobial coverage.
8. Saccharomyces Boulardii by Pure TheraPro – Best Probiotic for SIBO
No products found.
Saccharomyces boulardii is the one probiotic strain widely considered safe and beneficial during active SIBO treatment, and Pure TheraPro delivers a pharma-grade version.
Unlike bacterial probiotics that can worsen SIBO by adding more bacteria to an already overgrown small intestine, S. boulardii is a beneficial yeast that doesn’t colonize the small intestine. Research supports its use for diarrhea-predominant SIBO, and many SIBO specialists recommend it during and after antimicrobial treatment. Each capsule provides 10 billion CFU of the patented Lynside CNCM I-3799 strain with no fillers. The 120-count bottle provides a generous supply for extended treatment protocols.
Pros:
Safe to use during active SIBO treatment (unlike bacterial probiotics)
Patented pharma-grade strain with documented efficacy
No fillers — pure active ingredient
Cons:
Only one strain — not a comprehensive probiotic
Some individuals with yeast sensitivities should use caution
Best for: SIBO patients who want probiotic support during or after antimicrobial treatment without risking bacterial overgrowth exacerbation.
9. BioSchwartz Prebiotics & Probiotics – Best for Post-SIBO Recovery (15%)
Advanced Prebiotics and Probiotics for Women & Men, Immune, Digestive & Gut Health with L. Reuteri, Inulin Fiber, Digestive Enzymes, Non-GMO, Gluten-Free, Dairy-Free, 60 Capsules
Helps support digestive health: BioSchwartz’s prebiotic + probiotic 60 count mixes the best of both worlds in order to help your digestive tract flourish! The prebiotic can act as a fertilizer for the probiotic which helps to promote the good bacteria in your intestines in order to improve the function of your digestive system
Promotes the restoration of natural balance: Many intestinal issues majorly affect the body’s natural bacterial balance. With the right prebiotic + probiotic, your body can find that sense of balance again to help perform to its maximum potential
Purity tested & allergen free: Each and every batch of these prebiotic + probiotic capsules are third party tested to guarantee high purity, potency, and premium quality. This supplement has been manufactured without gmos, soy, gluten, wheat, tree nuts, peanuts, or sugar. They also don’t include preservatives or artificial colorants
Formulated by professionals: Each one of BioSchwartz’s professional grade supplements is created by a team of highly experienced healthcare professionals in the USA following strict GMP guidelines to ensure the greatest benefits are achieved
Setting a New High Standard for Quality – to ensure our prebiotic and probiotic supplements are effective and deliver on the high standards our customers expect, every capsule is made with care in a cGMP compliant facility in the USA with the finest globally sourced ingredients – with zero GMOs or unnecessary fillers
Once SIBO treatment is complete, restoring a healthy gut microbiome is essential for preventing relapse — and BioSchwartz offers a well-balanced pre/probiotic combination for this phase.
This formula combines multiple probiotic strains with prebiotics for comprehensive microbiome restoration after SIBO treatment. The advanced delivery system helps ensure live cultures reach the intestine. With a solid balance of Lactobacillus and Bifidobacterium strains, it provides the foundation for rebuilding a healthy microbial environment in the gut. This type of broad-spectrum probiotic is recommended by practitioners after the antimicrobial “kill phase” to repopulate the gut with beneficial organisms and reduce the risk of SIBO recurrence.
Pros:
Balanced multi-strain formula for post-treatment gut restoration
Includes prebiotics to feed beneficial bacteria
Helps prevent SIBO recurrence after antimicrobial treatment
Cons:
Should not be used during active SIBO treatment without practitioner guidance
Prebiotics may initially increase bloating in sensitive individuals
Best for: Post-SIBO treatment recovery and relapse prevention after completing an antimicrobial protocol.
10. Ancestral Supplements Digestive Enzymes – Best Enzyme Support for SIBO (15%)
Ancestral Supplements Digestive Enzymes for Women & Men, 90 Capsules, with Probiotics and Grass Fed Beef Organs, Supports Gut Health, Digestive Health & Nutrient Absorption, Allergen Free, Non GMO
SUPPORTS DIGESTIVE EFFICIENCY: Formulated with a blend of digestive enzymes (Amylase, Lipase, Protease, Lactase) and probiotics (Bacillus subtilis) to help the body process fats, carbohydrates, and proteins, offering digestive support and aiding nutrient utilization.
NUTRIENT-DENSE ORGAN BLEND: Features a unique combination of grass-fed and grass-finished organs, including kidney, liver, pancreas, gallbladder, stomach, and duodenum, sourced from pasture-raised animals for a natural source of nutrition.
CRAFTED FOR QUALITY: Our digestive enzymes for men and women are made without common allergens, GMOs, fillers, or artificial additives, offering a clean and natural supplement for those seeking digestive support.
ETHICALLY SOURCED INGREDIENTS: Sourced from 100% grass-fed cows raised without hormones on lush pastures in New Zealand and Australia, and produced in small batches in the USA, ensu1ring high-quality standards and third-party verification.
INSPIRED BY ANCESTRAL WISDOM: Reflecting the principles of the Beef Organ Movement, our supplements are designed to offer vital nutrients that support overall well-being and help fill the nutritional gaps of a modern diet.
Digestive enzyme supplementation addresses a common root cause of SIBO — insufficient enzyme production that allows food to ferment and feed bacterial overgrowth.
Ancestral Supplements takes a whole-food approach with grass-fed, pasture-raised organ-derived enzymes and probiotics in a single capsule. The 90-capsule bottle provides a 30-day supply. By improving the breakdown of proteins, fats, and carbohydrates, digestive enzymes reduce the undigested food substrate that feeds bacterial overgrowth in the small intestine. This is particularly important for SIBO patients who often have concurrent low stomach acid or pancreatic enzyme insufficiency. The whole-food approach aligns with ancestral nutrition principles that many SIBO patients find supportive of their healing journey.
Pros:
Addresses root cause of SIBO by improving food breakdown
Grass-fed, pasture-raised whole-food sourcing
Combines enzymes and probiotics in one supplement
Cons:
Not suitable for vegetarians or vegans (animal-derived)
Enzymes alone won’t eliminate existing bacterial overgrowth
Best for: SIBO patients with concurrent digestive enzyme insufficiency who want a whole-food approach to improving nutrient breakdown and reducing fermentation.
How to Choose the Best SIBO Supplements
The most effective SIBO supplements depend on whether you have hydrogen-dominant, methane-dominant (IMO), or hydrogen sulfide SIBO — identified through a breath test. Berberine and neem are typically recommended for hydrogen-dominant forms, while allicin and oregano oil are preferred for methane-dominant SIBO. Many practitioners recommend combining two or more antimicrobials for broader coverage.
Look for enteric-coated or delayed-release formulations when possible. Since SIBO occurs in the small intestine, supplements need to survive stomach acid to reach the affected area. Products like enteric-coated peppermint oil and delayed-release capsule formats ensure active ingredients reach the small intestine intact.
Quality matters significantly with herbal antimicrobials. Practitioner-grade brands like Integrative Therapeutics, Metagenics, and Biotics Research undergo more rigorous testing than mass-market supplements. When working with berberine, allicin, or oregano oil, potency and purity directly impact treatment outcomes. Cheap alternatives may not deliver therapeutic doses of active compounds.
Timing supplements correctly within a SIBO protocol is essential. Antimicrobials are used during the “kill phase” (typically 4-8 weeks), while probiotics and gut-healing supplements are generally reserved for the rebuilding phase after treatment. Leaky gut repair supplements can be valuable during the recovery phase to restore intestinal barrier function.
Frequently Asked Questions
What is SIBO and what causes it?
SIBO (Small Intestinal Bacterial Overgrowth) is a condition where excessive bacteria colonize the small intestine, which normally has relatively low bacterial populations. Common causes include impaired gut motility (the migrating motor complex), low stomach acid, structural abnormalities, chronic stress, and frequent antibiotic use. Symptoms typically include bloating, gas, abdominal pain, diarrhea or constipation, and nutrient malabsorption.
Can supplements alone cure SIBO?
Research shows that herbal antimicrobial protocols can be as effective as pharmaceutical antibiotics (like rifaximin) for treating SIBO. However, supplements work best as part of a comprehensive approach that includes dietary modifications (such as low FODMAP or elemental diets), prokinetics to improve gut motility, and addressing underlying root causes. Without addressing the root cause, SIBO has a high recurrence rate regardless of treatment method.
How long should I take SIBO supplements?
A typical herbal antimicrobial protocol for SIBO runs 4-8 weeks. Some practitioners extend treatment to 8-12 weeks for stubborn cases, particularly methane-dominant SIBO. Symptom improvement often begins within the first 2-3 weeks, but completing the full course is important to prevent partial treatment and rapid recurrence. Post-treatment, a retesting breath test after 2-4 weeks helps confirm clearance.
Are probiotics safe to take with SIBO?
This depends on the type of probiotic. Saccharomyces boulardii (a beneficial yeast, not bacteria) is generally considered safe during SIBO treatment. However, bacterial probiotics containing Lactobacillus and Bifidobacterium strains are typically reserved for the post-treatment rebuilding phase, as adding more bacteria during active overgrowth can worsen symptoms. Always consult with a practitioner before adding probiotics to an active SIBO protocol.
What diet should I follow while taking SIBO supplements?
The most commonly recommended diets during SIBO treatment are the Low FODMAP diet, the Specific Carbohydrate Diet (SCD), or the SIBO Bi-Phasic Diet. These diets reduce fermentable carbohydrates that feed bacterial overgrowth, helping antimicrobials work more effectively. An elemental diet is sometimes used for severe cases. Post-treatment, foods are gradually reintroduced to identify individual triggers.
How do I know if SIBO has returned after treatment?
Recurrence of symptoms — especially bloating, gas, and altered bowel habits — is the primary indicator. A lactulose or glucose breath test can confirm recurrence by measuring hydrogen and methane levels. SIBO has a recurrence rate of 40-50% within a year if underlying causes aren’t addressed, which is why prokinetics, dietary management, and ongoing gut support are important parts of long-term management.