Nattokinase has become one of the most popular natural supplements for supporting healthy blood flow and circulation. This enzyme, derived from Japanese fermented soybeans, works by breaking down fibrin — a protein that can restrict blood flow when it accumulates in blood vessels. For those specifically seeking nattokinase to improve circulation, the key factors are potency (measured in FU), supporting ingredients that complement circulatory function, and overall formula quality. Clinical research has shown that nattokinase can support healthy fibrinolytic activity, promote normal blood pressure levels, and help maintain smooth, unobstructed blood flow throughout the cardiovascular system.
Quick Comparison
Product
Potency
Form
Best For
Rating
Lunakai Nattokinase 8000 FU
8,000 FU
Capsules
Best Overall
4.6/5
Luma Nutrition Nattokinase 4000 FU
4,000 FU
Capsules
Best Value
4.5/5
Toku Nattokinase 10,800 FU with K2
10,800 FU
Capsules
Most Potent
4.5/5
Vascular Control NAC + CoQ10
Varies
Capsules
Best Circulation Stack
4.4/5
Double Wood Nattokinase 4000 FU
4,000 FU
Capsules
Best Seller
4.5/5
Doctor’s Best Nattokinase 2000 FU
2,000 FU
Veg Caps
Best Trusted Brand
4.6/5
Horbäach Nattokinase 4000 FU
4,000 FU
Capsules
Best Budget Pick
4.5/5
1. Lunakai Nattokinase Supplement 8000 FU – Best Overall for Circulation
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Lunakai USA Made Nattokinase Supplement – 400mg Natto Enzyme, 8000 FU per Serving – Heart & Circulation Support – Non-GMO, 60ct, 4000 FU Capsule
Supports Circulation – Each serving delivers 8000 FU of nattokinase, traditionally sourced to assist in supporting normal blood flow.
Natural Heart Support – Our nattokinase supplement is formulated to complement daily routines focused on overall heart wellness support.
Clean & Simple Ingredients – Each capsule contains 200mg of nattokinase enzyme, delivering 4000 FU, sourced from fermented natto with no artificial flavors or additives.
Vegan-Friendly Formula – Our nattokinase supplement is 100% vegan and plant-based, with no animal-derived ingredients or gelatin.
Made in the USA – Manufactured in the United States in a facility that follows GMP (Good Manufacturing Practices) for quality and consistency.
With 8,000 FU per serving, Lunakai’s nattokinase delivers high-potency fibrinolytic activity specifically formulated to support heart health and healthy blood circulation.
Each serving provides 400mg of nattokinase enzyme delivering 8,000 fibrinolytic units — four times the standard dose found in most competing products. The high FU count means more active enzyme per serving targeting fibrin breakdown, which directly supports improved blood flow. The formula is non-GMO, manufactured in USA GMP-certified facilities, and comes in a 60-count bottle. For anyone prioritizing circulation, this high-potency approach means you get meaningful enzyme activity from a single daily serving rather than having to stack multiple lower-dose capsules.
Pros:
8,000 FU per serving provides strong circulatory support
USA-made with GMP certification and clean manufacturing
Non-GMO formula with no unnecessary fillers
Cons:
Premium pricing compared to lower-dose options
Derived from soy fermentation, contains trace soy
Best for: Those who want maximum nattokinase potency for circulation support from a trusted USA brand
2. Luma Nutrition Nattokinase 4000 FU – Best Value for Circulation
Luma Nutrition Nattokinase Supplement – Natto 4000 FU Per Serving, Premium Heart Health Support – Vegan & Gluten Free – 60 Capsules – Made in USA
Premium Natto Extract: Luma Nutrition’s powerful nattokinase supplement boasts superior quality and a powerful dosage of Nattokinase 4000 fu, twice as strong as other nattokinase 2000 fu products. These effective Nattokinase powder capsules promote healthy blood flow and circulation, supporting cardiovascular function and overall heart health.
Natural Heart Support: Nattokinase is an enzyme extracted from natto, a traditional Japanese fermented soybean dish. It’s renowned for its fibrinolytic properties, meaning it helps break down fibrin, a protein involved in restricted blood flow. Without the presence of Serrapeptase or Lumbrokinase, this supplement works for vegan or gluten-free diets.
30 Day Supply: Each bottle of Luma’s nattokinase supplement organic lasts for a month to maintain optimal freshness and provides natural heart health support. This nattokinase supplement for men and women makes the perfect monthly subscription.
3rd Party Tested: All of our products are 3rd party tested for purity and quality. Our Nattokinase is made in the USA in our fully certified facility. Non-gmo and the highest quality.
Proudly USA: All Luma Nutrition supplements are manufactured in GMP certified facilities in the United States to ensure product safety and quality is always upheld. Certificed by NSF December 2023. We are veteran owned and operated.
Luma Nutrition’s nattokinase balances effective circulatory support at 4,000 FU per serving with an accessible price point, making it ideal for daily long-term use.
Each serving delivers 4,000 FU of nattokinase enzyme — twice the standard dose — in vegan, gluten-free capsules. Luma Nutrition focuses on premium quality at fair prices, with all products third-party tested and manufactured in GMP-certified USA facilities. The 4,000 FU potency provides clinically relevant fibrinolytic activity for blood flow support without the higher cost of ultra-potent formulas. The formula specifically highlights heart health and circulation support on its label. Those looking to support circulation from multiple angles may want to explore dedicated circulation supplements alongside nattokinase.
Pros:
4,000 FU potency at a competitive price
Third-party tested for purity and quality
Vegan, gluten-free, and made in USA
Cons:
30-day supply per bottle
Contains trace soy from nattokinase extraction
Best for: Daily circulation support at an affordable price with verified quality standards
3. Toku Nattokinase 10,800 FU with Vitamin K2 – Most Potent for Circulation
Toku Nattokinase 10,800 FU Supplement with Vitamin K2 MK7 & Oat Beta Glucan, Daily Circulation Support Powder, Plant-Based Drink Mix, Soy-Free, 30 Single-Serve Packets
DAILY WELLNESS SUPPORT: Toku Flow is a once-daily powder designed to support heart and vascular health with functional ingredients rooted in Eastern wellness traditions and backed by science.
CLINICALLY STUDIED NATTOKINASE: Delivers 10,800 FU of nattokinase, an enzyme derived from fermented Japanese natto, to help promote healthy blood flow and encourage natural enzyme activity in the body.
VITAMIN K2 FOR CALCIUM BALANCE: Includes 180 mcg of Vitamin K2 MK7 to help support proper calcium utilization and vascular health by guiding calcium toward the bones and away from soft tissues.
BETA GLUCAN FROM ORGANIC OAT BRAN: Provides 3g of organic oat bran per serving, standardized to 10% beta glucan, a naturally occurring soluble fiber known to help support internal balance and healthy nutrient metabolism.
PURE, PLANT-BASED FORMULA: A vegan-friendly powder that blends easily into water or your favorite beverage, free from soy and synthetic additives—offering gentle, effective support without pharmaceuticals.
Toku’s flagship nattokinase capsule delivers an industry-leading 10,800 FU per serving, paired with vitamin K2 MK-7 and oat beta-glucan for a comprehensive circulatory and arterial health formula.
Each serving provides 10,800 FU of soy-free nattokinase — the highest potency available in a capsule format. The addition of vitamin K2 MK-7 supports arterial flexibility and directs calcium away from blood vessel walls, while oat beta-glucan contributes to healthy cholesterol levels. This multi-pronged approach targets circulation from multiple angles: fibrin breakdown via nattokinase, arterial health via K2, and cardiovascular risk factors via beta-glucan. The soy-free extraction process is a significant advantage for those with soy allergies.
Pros:
Highest potency nattokinase available at 10,800 FU
Soy-free — rare and important for allergy-conscious users
Vitamin K2 and oat beta-glucan add arterial and cholesterol support
Cons:
Vitamin K2 inclusion makes it unsuitable for anticoagulant users
Higher price reflects the premium potency and multi-ingredient formula
Best for: Maximum-potency circulation support with added arterial health benefits in a soy-free formula
4. Vascular Control – NAC, CoQ10, Benfotiamine & Betaine – Best Circulation Stack
DrVmd Vascular Control – NAC, CoQ10, Benfotiamine, Betaine (3 Month Supply) Circulation, Heart Health, Energy & Endurance Support – Antioxidant B Vitamins Supplement
Supports Healthy Blood Flow and Circulation – CoQ10, NAC and betaine (a key nutrient naturally found in beets) promote vascular integrity, nitric oxide activity, and endothelial health to help maintain circulation and oxygen delivery.
Cardiovascular and Heart Health – Benfotiamine, vitamin D3, and a complete B-complex work together to help support vascular flexibility, balanced circulation, and cardiovascular resilience for daily heart wellness.
Energy, Stamina and Endurance – CoQ10, B vitamins and NAC fuel mitochondrial energy production, encouraging vitality, focus, and stamina for both daily performance & healthy aging.
Antioxidant and Metabolic Balance – NAC 300mg and vitamin D3 provide antioxidant defense while supporting healthy lipid metabolism, glucose metabolism, immune balance, and overall vascular health.
Physician-Created Trusted Quality – Developed by Dr. Robert Vogel, practicing physician and professor with 30+ years of clinical expertise. Every DrVMD formula is GMP-certified, third-party tested & made in the USA for quality you can trust.
This comprehensive vascular health formula combines nattokinase-supporting ingredients like NAC, CoQ10, benfotiamine, and betaine to target circulation, endothelial function, and blood vessel health from multiple angles.
Vascular Control takes a different approach from standalone nattokinase by combining multiple ingredients that support vascular function and circulatory wellness. NAC (N-Acetyl Cysteine) supports glutathione production and endothelial health, CoQ10 fuels the energy needs of cardiovascular tissue, benfotiamine protects blood vessels from glycation damage, and betaine supports homocysteine metabolism — all factors that contribute to healthy circulation. The three-month supply makes this an economical choice for long-term vascular support.
Pros:
Multi-ingredient approach targeting circulation from multiple pathways
NAC and CoQ10 support endothelial and cardiovascular function
Three-month supply provides excellent long-term value
Cons:
Does not contain nattokinase directly — complements rather than replaces it
More complex formula may not suit those wanting a single-ingredient approach
Best for: Those who want a comprehensive vascular health stack to pair with or as an alternative to standalone nattokinase
5. Double Wood Nattokinase 4000 FU – Best Seller for Circulation
Nattokinase Supplement 4,000 FU Servings, 120 Capsules (Derived from Japanese Natto) Systemic Enzymes for Cardiovascular and Circulatory Support by Double Wood
CARDIOVASCULAR HEALTH: Nattokinase may help support a healthy circulatory system by lowering plasma levels of certain proteins that affect circulation
CIRCULATORY SUPPORT: Research suggests that Nattokinase may help support cardiovascular health by promoting a healthy circulatory system
DERIVED FROM SOY (JAPANESE NATTO): Since Nattokinase is derived from fermented soybeans (Japanese Natto), there may be trace amounts of soy in the product. Do not take it if you are allergic to soy
TWO-MONTH SUPPLY: Our Nattokinase supplement contains 60 servings of 200 mg (4,000 FU), which equals 120 capsules (100 mg, 2,000 FU per capsule)
ROOTED IN QUALITY: Double Wood’s Nattokinase is manufactured right here in the USA from Globally Sourced Ingredients, Vegetarian, Non-GMO, and gluten-free
One of the highest-reviewed nattokinase supplements on Amazon, Double Wood’s 120-capsule bottle delivers 4,000 FU per serving with a two-month supply that has earned thousands of positive reviews for circulatory support.
Each two-capsule serving provides 200mg (4,000 FU) of nattokinase derived from Japanese natto. The 120-count bottle doubles the supply of most 60-count competitors, and the product holds Amazon’s Choice designation with over 2,000 reviews averaging 4.5+ stars. Many reviewers specifically note improvements in circulation and energy levels. Double Wood manufactures in the USA and the formula is vegetarian, non-GMO, and gluten-free. For those also interested in boosting blood flow through nitric oxide support, L-arginine supplements can complement nattokinase well.
Pros:
120-capsule bottle provides a full two-month supply
Amazon’s Choice with thousands of verified positive reviews
USA-manufactured, vegetarian, non-GMO, and gluten-free
Cons:
Requires two capsules per serving
Contains trace soy from fermentation process
Best for: Anyone who wants a widely trusted, highly reviewed nattokinase with proven consumer satisfaction for circulation
6. Doctor’s Best Nattokinase 2000 FU – Best Trusted Brand for Circulation
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Doctor’s Best delivers research-backed nattokinase at 2,000 FU per capsule with vitamin K2 removed, making it the go-to choice for circulation support among those on blood-thinning medications.
Each vegetarian capsule contains 2,000 FU of nattokinase with vitamin K2 specifically removed during processing. This is critical for people taking anticoagulants like warfarin, where vitamin K intake must be carefully managed. Doctor’s Best has been a trusted supplement brand for over 35 years, and their nattokinase formula is backed by published research on the fibrinolytic properties of the enzyme. The product is vegan, non-GMO, and gluten-free. For comprehensive heart and circulation support, consider pairing this with omega-3 supplements.
Pros:
Vitamin K2 removed — essential for anticoagulant users
35+ year brand reputation with science-backed formulas
Vegan, non-GMO, and gluten-free
Cons:
2,000 FU per capsule is lower than many competitors
May need to take 2 capsules daily for more robust circulation support
Best for: Anticoagulant users and those who want a research-backed nattokinase from a physician-trusted brand
7. NatureBell Nattokinase 8000 FU – Best High-Count Bottle
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NatureBell delivers an impressive 8,000 FU per serving in a massive 240-capsule bottle, providing four months of high-potency nattokinase for sustained circulatory support at exceptional value.
Each serving provides 8,000 FU of nattokinase from fermented natto extract in a 240-capsule bottle — one of the largest supplies available in the category. NatureBell focuses on max-strength formulations with transparent labeling and third-party testing. The high capsule count combined with potent dosing makes this one of the best values per serving for those committed to long-term nattokinase supplementation for circulation. The product is non-GMO and made for both men and women.
Pros:
240-capsule bottle provides up to a four-month supply
8,000 FU per serving matches premium potency standards
Outstanding cost per serving for high-potency nattokinase
Cons:
Large bottle may be overkill for those new to nattokinase
Contains soy from the fermentation source
Best for: Long-term nattokinase users who want a high-count bottle with premium 8,000 FU potency
8. Horbäach Nattokinase 4000 FU – Best Budget Pick for Circulation
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Horbäach Nattokinase Supplement 4000 FU | 150 Capsules | Non-GMO, Gluten Free
NATTOKINASE: This powerful enzyme is derived from the Japanese soybean called Natto
INNOVATIVE SUPPORT: Delivers 4000 FUs of Nattokinase per serving in convenient quick-release capsules
EXPERTLY CRAFTED: Our professional formula is backed by our commitment to purity and potency
HORBAACH MANUFACTURERS: Laboratory Tested, Trusted Ingredients, Superior Quality, 100% Guaranteed!
NATURALLY FREE OF: Gluten, Wheat, Milk, Lactose, Artificial Flavor, Color, Preservatives & Non-GMO
Horbäach’s 150-capsule bottle of nattokinase delivers 4,000 FU per serving at one of the lowest cost-per-serving price points in the category, backed by 40+ years in the supplement industry.
Each two-capsule serving provides 4,000 FU of nattokinase in quick-release capsules designed for efficient absorption. The 150-count bottle provides a 75-day supply — 25% more than standard 60-count bottles — making it an excellent value proposition. Horbäach has been in the natural products industry for over four decades, with all products laboratory tested for quality and purity. The formula is non-GMO, gluten-free, and free from artificial flavors, colors, and preservatives.
Pros:
150-count bottle offers exceptional value per serving
Quick-release capsule format for efficient absorption
40+ year brand heritage with laboratory-tested quality
Cons:
Uses gelatin capsules, not vegan-friendly
Requires two capsules per serving to reach 4,000 FU
Best for: Budget-conscious shoppers who want affordable, reliable nattokinase for daily circulation support
How to Choose the Best Nattokinase for Circulation
When choosing nattokinase specifically for circulation, prioritize potency measured in fibrinolytic units (FU). The enzyme’s circulation-supporting benefits come from its ability to break down fibrin, and higher FU counts mean more fibrinolytic activity per serving. For general circulatory maintenance, 2,000-4,000 FU daily is a solid starting point. For more aggressive circulation support, products delivering 8,000-10,000 FU offer greater enzyme activity. When comparing products, always check the FU per serving rather than just the milligram count, as enzyme activity can vary significantly between manufacturers even at the same milligram dose.
Consider whether you want a standalone nattokinase or a formula with complementary circulation ingredients. Vitamin K2 MK-7 supports arterial flexibility and helps direct calcium away from blood vessel walls and into bones. Omega-3 fatty acids reduce inflammation in blood vessels, CoQ10 fuels cardiovascular cell energy, and ingredients like beetroot and L-arginine boost nitric oxide production for vasodilation. However, if you take anticoagulant medications, choose a nattokinase with vitamin K2 removed (often labeled “K2-free” or “NSK-SD”) to avoid interfering with your medication’s effectiveness.
Timing matters for nattokinase and circulation. Most experts recommend taking nattokinase on an empty stomach for maximum fibrinolytic activity, as food can divert the enzyme toward digestive functions rather than systemic circulation. Some research suggests evening dosing may provide better support for overnight circulation, when blood flow naturally slows and the risk of clot formation may increase. Consistent daily use is important, as the circulatory benefits of nattokinase build cumulatively over time with regular supplementation.
Look for products that are third-party tested, GMP-certified, and transparent about their FU potency per serving. Soy-free options are available for those with allergies, though they tend to come at a higher price point. The NSK-SD form of nattokinase has the most published clinical research specifically supporting its fibrinolytic and circulatory benefits. For a comprehensive approach to circulatory health, nattokinase can be effectively paired with blood pressure support supplements, L-arginine for nitric oxide production, or omega-3 fatty acids for vascular inflammation support.
Frequently Asked Questions
What is nattokinase and how does it help circulation?
Nattokinase is a fibrinolytic enzyme extracted from natto, a traditional Japanese fermented soybean food. It supports circulation primarily by breaking down fibrin, a protein involved in blood clot formation that can restrict blood flow when it accumulates in blood vessels. By reducing fibrin levels, nattokinase helps maintain smoother blood flow and supports overall cardiovascular health. Research also suggests it may support healthy blood pressure levels by helping regulate angiotensin-converting enzyme (ACE) activity. First isolated by Japanese researcher Dr. Hiroyuki Sumi in 1987, nattokinase has become one of the most studied natural fibrinolytic agents available and is widely used in Japan, Korea, and increasingly in the Western world for cardiovascular and circulatory support.
How much nattokinase should I take for circulation?
For circulation support, most research and practitioners recommend 2,000-4,000 FU (fibrinolytic units) daily as a starting dose. Those seeking more intensive support often use products delivering 8,000-10,000 FU. Start with a lower dose and increase gradually based on your response. Always consult a healthcare provider before starting nattokinase, especially if you take blood-thinning medications.
When is the best time to take nattokinase for circulation?
Take nattokinase on an empty stomach between meals for optimal enzyme activity. Many circulation-focused users take it in the evening before bed, as blood flow naturally slows during sleep and nattokinase may help maintain healthy overnight circulation. Some people split their dose, taking half in the morning and half in the evening for more sustained fibrinolytic activity throughout the day.
Are there any side effects of nattokinase?
Nattokinase is generally well-tolerated at recommended doses. The primary safety concern is its blood-thinning properties — do not take nattokinase if you are on anticoagulant medications (warfarin, heparin), have a bleeding disorder, or are preparing for surgery without medical guidance. Mild digestive discomfort can occur when starting. Those with soy allergies should choose soy-free formulations.
Can I take nattokinase with blood pressure medication?
Nattokinase may have a mild blood pressure-lowering effect, so combining it with blood pressure medications could potentially cause blood pressure to drop too low. Always consult your healthcare provider before adding nattokinase to your regimen if you take any blood pressure or blood-thinning medications. Monitoring blood pressure regularly when starting nattokinase is recommended.
How long does it take for nattokinase to improve circulation?
Nattokinase begins fibrinolytic activity within hours of ingestion, with peak blood levels typically occurring 4-6 hours after a dose. However, meaningful improvements in circulation and blood flow are generally noticed after 4-8 weeks of consistent daily use. Studies measuring blood pressure and circulatory markers have typically run 4-12 weeks to show significant improvements.