Memory decline is one of the most common cognitive concerns, whether from aging, stress, or lifestyle factors. The right brain supplement can support neurotransmitter function, protect neurons from oxidative damage, and improve blood flow to the brain. These are the best memory supplements available in 2026, selected for ingredient quality, clinical evidence, and real-world results.
Quick Comparison
Product
Key Ingredient
Form
Best For
Rating
Effective Nutra Mushroom Gummies
Lion’s Mane + 10 Mushrooms
Gummies
Best Overall
4.6/5
Lunakai Super Mushroom Gummies
Lion’s Mane + Adaptogens
Gummies
Best Mushroom Blend
4.5/5
Effective Nutra Shilajit Gummies
Shilajit 1000mg
Gummies
Best for Brain Energy
4.5/5
NATURELO Brain Supplement
Multi-Nutrient Nootropic
Capsules
Best Whole-Food Formula
4.4/5
PYM Attention Chews
L-Carnitine + B12
Chews
Best for Focus + Memory
4.3/5
Vital Nutrients Ultra Pure Fish Oil
DHA + EPA Omega-3
Softgels
Best Fish Oil for Brain
4.6/5
Neviss Focus Brain Gummies
Lion’s Mane + B6 + B12
Gummies
Best Budget
4.3/5
1. Effective Nutra Mushroom Gummies 2500mg – Best Overall
Effective Nutra Mushroom Gummies 2500mg – 10in1 Lion’s Mane, Reishi, Chaga, Cordyceps & More – Focus, Clarity, Memory, Immunity, Energy – Natural Raspberry Flavor, Vegan, Made in USA (90 Count)
SHARPER FOCUS, CLARITY & MEMORY – Our mushroom gummies are specifically formulated to support cognitive function and mental performance. With Lions Mane as the star ingredient plus 9 complementary functional mushrooms, each serving delivers 2500mg of concentrated extracts to help you stay mentally sharp, focused, and clear-headed throughout your day. Just 2 delicious raspberry gummies daily.*
BRAIN, ENERGY & IMMUNITY IN ONE POWERFUL GUMMY – Experience the triple benefits of functional mushrooms: support mental clarity and cognitive performance, enjoy sustained natural energy without jitters or crashes, plus strengthen your immune system. Our comprehensive formula works synergistically to optimize your mental and physical wellness for peak daily performance.*
POTENT 10 MUSHROOM BLEND – Lions Mane leads our formula for brain power and cognitive support, joined by Cordyceps (energy and vitality), Reishi (stress balance and immunity), Chaga (cellular health), Turkey Tail (gut and immune support), Shiitake (heart health), Maitake (metabolic health), White Button (cholesterol support), Black Fungus (antioxidants), and Royal Sun (liver support).*
DELICIOUS & EASY TO TAKE – Forget hard-to-swallow capsules and bitter mushroom powders. Our naturally raspberry-flavored gummies taste amazing with absolutely no earthy mushroom aftertaste. Each bottle contains 90 gummies providing a full 45-day supply – the best value available. Customers love saying “these don’t taste like mushrooms at all!” Making smart supplementation enjoyable and convenient.*
QUALITY YOU CAN TRUST – Made in USA in GMP-certified facilities using concentrated 10:1 fruiting body extracts (250mg each mushroom, never inferior mycelium fillers). Third-party tested for purity and potency with ingredient integrity verified before production. Vegan, Gluten-Free, Non-GMO, Caffeine-Free with no artificial colors or flavors. Fits every healthy lifestyle.*
A 10-in-1 mushroom complex led by lion’s mane that delivers powerful nootropic and neuroprotective benefits in a sugar-free gummy.
Effective Nutra packs 2500mg of functional mushroom blend per serving, including lion’s mane (the most clinically studied mushroom for memory and nerve growth factor production), reishi, chaga, cordyceps, maitake, shiitake, turkey tail, and more. Lion’s mane contains hericenones and erinacines — compounds shown to stimulate nerve growth factor (NGF), which plays a critical role in memory formation and neuroplasticity. The sugar-free formula makes this a clean daily nootropic. Made in the USA under GMP standards.
Pros:
10 functional mushrooms with lion’s mane as the lead ingredient
Sugar-free formula
Supports both memory and overall brain resilience
Cons:
Mushroom dose is split across 10 species
Individual mushroom doses not disclosed
Best for: Anyone seeking a comprehensive mushroom nootropic for memory and cognitive resilience
2. Lunakai Super Mushroom Gummies – Best Mushroom Blend
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Lunakai USA Made Super Mushroom Gummies for Adults – 10-in-1 Adaptogenic Mushroom Supplement with Lion’s Mane – Daily Focus & Brain Support, 60ct
Comprehensive 10 Mushroom Blend – Packed with Lions Mane, Reishi, Cordyceps, and more functional mushrooms, this multi-mushroom supplement is designed to support overall wellness and vitality.
Supports Focus & Cognitive Function – These mushroom gummies are specially crafted to help maintain focus, memory, and brain health with adaptogenic mushrooms like Lions Mane and Reishi.
Energy & Vitality Support – Feel naturally revitalized throughout the day with super mushroom daily gummies designed to support energy levels and overall performance.
Immune System Support – Infused with 10 super mushrooms, including Chaga and Turkey Tail, known for their immune properties to keep you feeling your best.
Delicious & Convenient Gummies – Enjoy the benefits of mushroom vitamins in a tasty watermelon-flavored gummy form, perfect for adults looking for an easy addition to their daily routine.
A 10-in-1 adaptogenic mushroom supplement with lion’s mane and complementary mushrooms for memory, focus, and stress resilience.
Lunakai’s Super Mushroom gummies feature a 10-mushroom blend led by lion’s mane alongside reishi (for stress reduction), cordyceps (for brain energy), and chaga (for antioxidant neuroprotection). The adaptogenic properties of this blend support cognitive function under stress — a major contributor to memory problems. The gummies are naturally flavored, easy to chew, and provide a convenient daily mushroom supplement without the earthy taste of powders or capsules. Made in the USA.
Pros:
Adaptogens reduce stress-related memory impairment
Convenient gummy format with pleasant taste
10 mushroom species for broad cognitive support
Cons:
Less concentrated than capsule mushroom extracts
Contains added sugar
Best for: People who want mushroom-based memory support in a delicious, easy-to-take gummy
3. Effective Nutra Shilajit Gummies 1000mg – Best for Brain Energy
EFFECTIVE NUTRA Shilajit Gummies 1000mg | Pure Shilajit Resin for Energy, Brain & Immunity | Supplement for Men & Women | Sugar-Free, Vegan, Gluten-Free | Natural Berry Flavor, Made in USA (90ct)
Premium Himalayan Shilajit: Made from pure, high-altitude Himalayan shilajit, our gummies deliver essential minerals and natural compounds to help you feel your best every day. Our Shilajit supplement is packed in a potent blend that may aid in boosting energy, enhancing brain function, supporting heart health, and fortifying the immune system. It’s a comprehensive solution for men and women looking to maintain optimal health and vitality.*
Natural Energy & Vitality Boost You Can Trust: Harness the centuries-old benefits of shilajit to feel more energized and vital every day. Our sugar-free gummies are an easy and convenient way to incorporate this natural wellness booster into your routine, supporting active and balanced living.*
Brain Health, Focus, and Immune Support: Designed to promote mental clarity, focus, and immune wellness, these shilajit gummies offer a natural approach to enhancing your day-to-day health without compromising on taste or convenience.*
Convenient & Easy-to-Take Gummies: No more dealing with messy powders or hard-to-swallow capsules! Our naturally flavored, sugar-free gummies are designed for convenience and taste, making it easier than ever to enjoy the benefits of shilajit. Simply take 2 gummies daily or as recommended by your healthcare professional. Each bottle includes 90 gummies, providing a 45-day supply.*
For Every Lifestyle: Effective Nutra Shilajit Gummies are Vegan, Non-GMO, Gluten-Free, Dairy-Free, Soy-Free, Gelatin-Free, and Pectin-Based. Produced in a GMP-certified facility and rigorously third-party tested, these gummies are crafted with clean ingredients to fit into any wellness routine.*
A purified shilajit supplement delivering fulvic acid and trace minerals that support mitochondrial energy production in brain cells.
Effective Nutra provides 1000mg of shilajit resin per serving in a sugar-free gummy. Shilajit contains fulvic acid, which acts as an electron carrier that enhances mitochondrial function — the energy factories inside every brain cell. Research suggests that fulvic acid may also reduce tau protein aggregation, a process associated with cognitive decline. The trace minerals in shilajit (iron, zinc, magnesium) support neurotransmitter synthesis essential for memory encoding.
Pros:
Targets brain energy at the mitochondrial level
Rich in fulvic acid and trace minerals
Sugar-free gummy format
Cons:
Research on shilajit is still emerging
Not as well-studied as omega-3s or lion’s mane
Best for: People experiencing brain fog or mental fatigue who want to support cellular brain energy
4. NATURELO Whole Food Brain Supplement – Best Whole-Food Formula
NATURELO Whole Food Brain Supplement – Brain Health Supplements for Memory & Focus Support – Enhance Brain Health Blend Supplement for Adults – 60 Vegetarian Capsules
MEMORY SUPPLEMENT FOR BRAIN HEALTH: Naturelo Brain Blend is a brain health supplement for memory and focus support, assisting with recalling words and retaining facts can become more challenging with age. Naturelo formula includes BacoMind(R), a standardized Bacopa extract, which has been clinically shown to enhance memory and learning in older adults.
FOCUS SUPPLEMENT: Naturelo cognitive health supplement helps you stay on task without the need for stimulants providing you with natural mental energy support. Naturelo stimulant-free formula features Brain berry(R), a standardized, high potency Aronia berry extract, which has been clinically shown to help support concentration and brain fitness.
BRAIN HEALTH SUPPLEMENT: Essential vitamins like B complex and vitamin C help maintain brain health and support a healthy mood. Naturelo Brain Health vitamin formula includes high potency B12, an especially vital brain nutrient for older adults.
BRAIN HEALTH SUPPLEMENTS FOR ADULTS: Naturelo brain support supplement contains botanicals such as lion’s mane, turmeric, blueberry, and eleuthero, which are rich in antioxidants that can cross the blood-brain barrier and protect cells against free radicals as a result of oxidative stress.
JUST THE GOOD STUFF: Naturelo believes the best supplements come from nature, not from a lab. This plant-based supplement is non-GMO and vegan-friendly, with no preservatives, coloring, or flavoring, and no dairy or soy.
A plant-based nootropic combining whole-food vitamins with clinically studied brain nutrients for comprehensive memory support.
NATURELO takes a whole-food approach to brain health, combining organic plant-based vitamins with targeted nootropic ingredients for memory and focus. The formula includes key B vitamins for neurotransmitter production, antioxidants for neuroprotection, and plant-derived nutrients that support brain blood flow. Free from synthetic fillers, GMOs, soy, and gluten. Each capsule is made with clean, plant-based ingredients aligned with a whole-food nutrition philosophy.
Pros:
Whole-food sourced vitamins for better absorption
Comprehensive formula targeting multiple brain pathways
Clean label with no synthetic fillers
Cons:
Requires multiple capsules per day
Premium price for whole-food ingredients
Best for: Health-conscious individuals who prefer whole-food-sourced brain nutrition over synthetic alternatives
5. PYM Attention Chews – Best for Focus + Memory
PYM Attention Chews Support for Procrastination, Focus & Productivity, 20 Count | 518mg L-Carnitine, 54mg Tyrosine, 11mg L-Taurine, Caffeine-Free | All-Natural Mood Boost Supplement Made in USA
Prepare Your Mind: PYM Attention Chews are formulated with all-natural vegan ingredients to help turn a distracted mind into a productive mind. Take up to two chews to get into a flow state for hours of calm, yet focused productivity.
Mindful Blend Of Ingredients: Our caffeine-free chews are made with 518mg of L-Carnitine and 54mg of Tyrosine to help support your energy, fitness, and focus, as well as 11mg of L-Taurine to help ease stress and support your mood.
Clean & Caffeine-Free: Proudly manufactured in the USA, our mixed berry chews are non-GMO and keto-friendly, with no added sugars.
Everyday Solution To Everyday Focus: Designed by neuroscientists and nutritional psychiatrists, our blend of amino acids target the neurotransmitters that help your body manage stress, allowing you to naturally relax and focus with a calm state of mind.
A Mindful Mission: PYM’s mission is to provide natural and effective mental hygiene products to promote self-care and mental well-being. PYM prepares your mind to produce the naturally occurring neurotransmitters that help you feel like yourself again.
Clinically formulated chews with L-carnitine and B12 that support attention, productivity, and working memory without stimulants.
PYM Attention Chews deliver 518mg of L-carnitine — an amino acid that supports acetylcholine production, the neurotransmitter most directly involved in memory formation and recall. Combined with vitamin B12 for nerve health and energy metabolism, these chews provide stimulant-free cognitive support. The chewable format offers fast absorption without the need for water. Developed with input from mental health professionals and backed by clinical research on the individual ingredients.
Pros:
L-carnitine supports acetylcholine for memory
Stimulant-free formula
Convenient chewable format
Cons:
Smaller serving size (20 count)
Primarily focused on attention rather than long-term memory
Best for: People who need both sharper focus and better working memory without caffeine or stimulants
6. Vital Nutrients Ultra Pure Fish Oil 700 – Best Fish Oil for Brain Health
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Vital Nutrients Ultra Pure Fish Oil 700 – Supports Heart, Brain, and Joint Health* – Sustainably Sourced High EPA & DHA Omega-3 Fatty Acid – Lemon Flavor – Gluten, Dairy & Soy Free – 120 Softgels
Premium Omega-3 Fish Oil Supplements: Support your heart, brain, and joint health, plus promote healthy triglyceride levels.* Ultra Pure Fish Oil 700 offers a potent concentration of EPA (eicosapentaenoic acid) and DHA (docosahexaenoic acid), key omega-3 fatty acid supplements essential for optimal well-being
No Fish Oil Burps or Reflux: Enjoy our sustainably sourced, wild-caught fish oil supplement rich in omega-3 fatty acids, delivering 720mg of EPA and 480mg of DHA in two softgels. Enhanced with a pleasant lemon flavor, it eliminates the common “fishy” aftertaste associated with other fish oil supplements*
Clean Formula: Non-GMO. Made without artificial fillers, coatings, binders, or colors.
Quality You Can Rely on: Our rigorous quality assurance program includes third-party independent laboratory testing of raw ingredients and finished products for purity and potency to ensure what’s on the label is in the bottle.
Trusted by Healthcare Practitioners Worldwide: Vital Nutrients was founded 30 years ago by practitioners who set out to make a positive and lasting impact on the health of people and planet. Today, our premium line of clinically relevant, pure, clean-label formulas is trusted by healthcare practitioners and health-conscious consumers worldwide
A pharmaceutical-grade omega-3 delivering high DHA — the fatty acid that comprises 97% of the brain’s omega-3 content — in ultra-pure triglyceride form.
Vital Nutrients provides 700mg of combined EPA and DHA per softgel, with DHA being the critical omega-3 for brain structure and memory. DHA makes up a significant portion of brain cell membranes, and adequate levels are essential for synaptic plasticity — the process underlying learning and memory. Every batch is third-party tested for heavy metals, PCBs, and oxidation. Triglyceride form ensures superior absorption compared to ethyl ester fish oils.
Pros:
Pharmaceutical-grade purity with third-party testing
High DHA content for brain structure
Triglyceride form for optimal absorption
Cons:
Premium price point
Does not target nootropic pathways directly
Best for: People who want foundational brain nutrition through high-quality omega-3s
7. Effective Nutra Resveratrol Gummies 1500mg – Best Antioxidant for Brain
EFFECTIVE NUTRA Resveratrol Gummies 1500mg | Sugar-Free Supplement for Antioxidant Support, Immunity, Heart Health, and Brain Function | 45-Day Supply, Natural Berry Flavor, Made in USA (90 Count)
#1 RESVERATROL GUMMY: Our sugar free Resveratrol gummies taste great & go down easy. Each serving is packed with 1500mg. 90 Gummies in a bottle for the best value out there!*
GET ALL THE BENEFITS: Packed in a potent blend that may promote Heart Health, Immune System Support, Brain Function, Stress Relief, and Healthy Aging.*
ANTIOXIDANT SUPPORT: Each gummy is loaded with Resveratrol to fight oxidative stress and promote vitality.*
HEALTHY & DELICIOUS: Our Resveratrol gummies are sugar free, naturally raspberry watermelon flavored. No artificial colors or flavors!*
EFFECTIVE NUTRA EXCELLENCE: Vegan, Gluten-Free, Non-GMO, 3rd Party Tested, GMP Certified, Made in USA with Global Ingredients. Quality you can trust!*
A high-dose resveratrol gummy that protects brain cells from oxidative damage and supports cerebral blood flow.
Effective Nutra delivers 1500mg of resveratrol per serving in a sugar-free gummy. Resveratrol is a polyphenol antioxidant found in red grapes and berries that crosses the blood-brain barrier to protect neurons from oxidative stress. Studies suggest resveratrol may improve cerebral blood flow, enhance memory performance, and support neuroprotective pathways. The high dose and sugar-free formulation make this one of the most potent resveratrol supplements available in gummy form.
Pros:
Crosses blood-brain barrier for direct neuroprotection
1500mg high-potency dose
Sugar-free formula
Cons:
Resveratrol bioavailability can be limited
Best combined with other nootropics for memory
Best for: People who want antioxidant brain protection and support for cerebral blood flow
8. Neviss Focus Brain Gummies with Lion’s Mane – Best Budget
Neviss Kids 10+ Focus Brain Gummies w/Lion’s Mane, B6, Methyl B12, Mushroom Filled Gummy for Teen & Adults Memory & Energy, Phosphatidylserine, L-Tyrosine, Choline, Beetroot, Ginkgo Biloba, Sugar Free
[Gluten-free, soy-free, wheat & yeast-free and NON-GMO. 3rd-Party Tested.] [Unique Sugar-Free Filled Gummies for Teens 10+ & Adults] The delicious mushroom gummy features a gelatin-free chewy outer layer and a natural blueberry-flavored filling. Adopting advanced GummieJel Technology that encapsulates active ingredients – mushroom, multivitamin, L-Tyrosine, PS to ensure maximum potency and stability. Additionally, it wraps nutrients- Ginkgo Biloba, Beet Root, ß-zeaxanthin ,making nutrition easier to absorb.
[Your Brain’s Button for Learning & Curiosity.] Studying feel like a struggle? Presentation tomorrow? Struggling to maintain concentration through long lectures? Your brain is your most valuable asset—give it the elite support it deserves. Our mushroom gummies feature Lion’s Mane for cognitive health, w/ L-Tyrosine, Choline, Phosphatidylserine, Ginkgo Biloba Leaf. This powerful duo is designed to help with ment✿l cl✿rity and focus, so you can stay on task and absorb more information naturally.
[Your Daily Ritual for Ment✿l Cl✿rity & Balance.] For the Busy Professional, the 7 in 1 mushroom + multivitamin filled gummies power through your workday with clarity and focus. Power through lectures, dominate your inbox, and finally start that side project—all with the crisp, clean focus of a productivity ninja. Your most efficient self is waiting. Reishi and B-Vitamins and Beet Root work together to fuel your cells, supporting steady energy and composed focus.
[The 7-Mushroom Symphony for Healthy Aging Brain.] Unlock the profound, synergistic power of nature’s most intelligent fungi to protect your aging mind. A masterfully orchestrated blend of seven mushrooms, Lion’s Mane takes the lead, Reishi provides a harmonious foundation, they are powerfully complemented by Maitake, Shiitake, White Button, Enoki, and Oyster, each contributing a unique spectrum of beta-glucans and antioxidants. This powerful alliance works for brain & cellular health.
[Teens Sports & Energy Support: On-Ice Focus & Off-Ice Recvery] Dominate your game and your grades. The mushroom supplement is Game Changer for sports and classroom. Lion’s Mane and Phosphatidylserine synergize to help with focus for split-second game-time decisions and post-game study sessions. B-Vitamins convert your food into clean, natural energy to power through demanding days. Meanwhile, Reishi and crucial Vitamin D3 work behind the scenes to help your body maintain overall well-being.
An affordable lion’s mane gummy with B6 and B12 that delivers core nootropic benefits at a budget-friendly price.
Neviss combines lion’s mane mushroom with vitamin B6 and methyl B12 in a mushroom-filled gummy. B6 is essential for serotonin and dopamine synthesis, while B12 supports myelin sheath maintenance — the insulation around nerve fibers that ensures fast signal transmission. Lion’s mane provides NGF-stimulating compounds for memory and learning. This is a straightforward, no-frills formula that covers the basics of mushroom-based memory support at an accessible price point.
Pros:
Affordable entry point for mushroom nootropics
B6 and B12 support neurotransmitter production
Methyl B12 form for better absorption
Cons:
Lower mushroom dose than premium products
Marketed for kids 10+ but works for adults too
Best for: Budget-conscious buyers who want a simple lion’s mane + B-vitamin memory supplement
9. Zazzee Organic Lion’s Mane 20:1 Extract – Best Pure Lion’s Mane
Zazzee USDA Organic Lion’s Mane 20:1 Extract, 30% Polysaccharides, 16,000 mg Strength, 120 Vegan Capsules, Nootropic for Brain Health, Focus, Memory, Concentration and Immune Support, Made in The USA
OUTSTANDING VALUE: Our Certified Organic Lion’s Mane Extract contains 16,000 mg strength per capsule, is standardized to 30% Polysaccharides AND is USDA Certified Organic – an amazing value! A single bottle contains a 60 day supply. Compare this to other leading brands that are not standardized to 70% Polysaccharides, contain less than 120 capsules, are not organic, and use a much less potent, non-extract powder. Our Certified Organic Lion’s Mane Extract is a bargain not be found elsewhere!
USDA CERTIFIED ORGANIC: Any Lion’s Mane that is not CERTIFIED organic can be highly contaminated and even harmful. With Zazzee Naturals Certified Organic Lion’s Mane, you can be sure your Lion’s Mane is organic, all-natural, vegan, and non-GMO. More, while other competing products use various chemicals as fillers, binders, and excipients, our Organic Lion’s Mane instead uses a unique blend of organic stabilizers.
16,000 MG STRENGTH / POTENT 20:1 EXTRACT: Each capsule contains 16,000 mg strength of Lion’s Mane Extract from a potent, powerful 20:1 extract. Combine that with USDA Organic Certification, and our Extra Strength Organic Lion’s Mane Extract is one of the strongest dosages available!
30% POLYSACCHARIDES: Polysaccharides are the “good stuff”, the beneficial compound in Lion’s Mane that provides the desired results. Our Lion’s Mane Extract has been standardized to contain a minimum of 30% Polysaccharides, which is one of the highest standardization numbers available. The higher the numbers, the more potent the extract. Clearly, not all Lion’s Mane is created equal!
GOLD STANDARD PRODUCTION: Your health and safety mean everything to us. For that reason, our Extra Strength Lion’s Mane Extract is manufactured in the USA, in a fully certified facility with adherence to good manufacturing policies and under the most stringent quality control. You can rest assured that you get the best value for your money!
A concentrated 20:1 lion’s mane extract delivering the equivalent of 16,000mg per serving with 30% polysaccharides for maximum nootropic potency.
Zazzee provides a highly concentrated USDA organic lion’s mane extract standardized to 30% polysaccharides — the active compounds responsible for NGF stimulation. The 20:1 extraction ratio means each capsule delivers the equivalent of 16,000mg of raw lion’s mane mushroom. This is one of the most potent standalone lion’s mane supplements available. Vegan capsules, organic certification, and 120-count bottles (4-month supply) make this an excellent value for dedicated lion’s mane users.
Pros:
20:1 concentrated extract for maximum potency
Standardized to 30% polysaccharides
USDA organic certified
Cons:
Single-ingredient supplement
Capsule form only
Best for: People who want the highest-potency lion’s mane for serious memory and cognitive support
10. Ginkgo Biloba with Phosphatidylserine – Best Traditional Nootropic
Ginkgo Biloba 120mg with Phosphatidylserine – Nootropic Brain Health, Memory, and Focus Supplement – Supports Cognitive Function, Mental Clarity, and Alertness – 60 Non-GMO Capsules, 2 Month Supply
Nootropic Support – Each serving contains 120mg of ginkgo biloba and 100mg of phosphatidylserine to support brain health, memory, and focus, helping you stay sharp throughout the day.
Cognitive Function – Our ginkgo biloba capsules are formulated to support cognitive health, helping to promote mental alertness and clarity without the use of caffeine.
Herbal Supplement for Brain Health – Known for its strong antioxidant properties, ginkgo biloba supports cognitive function by delivering essential nutrients to the brain.
Caffeine-Free Energy Support – Unlike traditional energy supplements, our formula supports energy levels without the crash or jitters, making it ideal for maintaining steady focus and productivity.
Supports Mental Well-Being – Ginkgo biloba is traditionally used to support overall mental well-being, promoting a balanced mood and enhancing cognitive performance for daily mental tasks.
A classic nootropic pairing that combines ginkgo biloba’s circulation benefits with phosphatidylserine’s memory-enhancing properties.
This supplement pairs 120mg of ginkgo biloba extract with phosphatidylserine — a phospholipid that is a key component of brain cell membranes. Ginkgo biloba has been used for centuries to support cerebral blood flow, and modern research confirms it may improve memory and processing speed in older adults. Phosphatidylserine supports memory consolidation, cortisol management, and cognitive function under stress. The combination targets both blood flow and cell membrane health for dual-mechanism memory support.
Pros:
Two well-studied nootropic ingredients in one supplement
Ginkgo improves cerebral blood flow
Phosphatidylserine supports memory consolidation
Cons:
Ginkgo may interact with blood thinners
Results may take 6-8 weeks
Best for: Adults who want a traditional, research-backed nootropic combination for memory support
How to Choose the Best Brain Supplement for Memory
The most effective memory supplements work through one or more key mechanisms: stimulating nerve growth factor (lion’s mane), providing structural brain fats (DHA/omega-3), supporting neurotransmitter production (B vitamins, L-carnitine), improving cerebral blood flow (ginkgo biloba), or protecting neurons from oxidative damage (resveratrol, antioxidants). The best approach often combines two or more of these mechanisms.
Lion’s mane mushroom has emerged as the leading natural nootropic for memory, with studies showing it stimulates NGF production and may improve mild cognitive impairment. Look for extracts standardized to polysaccharides or hericenones/erinacines, with a high extraction ratio (10:1 or 20:1) for concentrated potency. DHA omega-3 is the foundational brain nutrient — it comprises a large portion of brain cell membranes and supports synaptic function essential for memory.
B vitamins (B6, B12, folate) are essential for neurotransmitter synthesis and homocysteine metabolism. Elevated homocysteine is linked to accelerated cognitive decline, making B-vitamin supplementation particularly important for older adults. Phosphatidylserine (100-300mg daily) supports memory consolidation and has FDA-qualified health claims for cognitive function.
Avoid products making extreme claims about reversing memory loss or preventing dementia — no supplement can do this. Look for GMP-certified, third-party tested products. People taking blood thinners should consult a doctor before taking ginkgo biloba or high-dose omega-3s. Allow 4-12 weeks of consistent use before evaluating results, as brain supplements work gradually through structural and biochemical changes.
Frequently Asked Questions
What is the best supplement for memory and brain function?
Lion’s mane mushroom and omega-3 fish oil (high in DHA) are the two most evidence-backed supplements for memory. Lion’s mane stimulates nerve growth factor production, while DHA provides structural support for brain cell membranes. Combining both offers complementary mechanisms — NGF stimulation for neuroplasticity and structural fatty acids for synaptic health.
How long do brain supplements take to work?
Most brain supplements require 4 to 12 weeks of consistent daily use before noticeable improvements in memory and cognitive function. Lion’s mane studies typically show results within 4-8 weeks. Omega-3s may take 8-12 weeks to fully incorporate into brain cell membranes. Ginkgo biloba usually shows effects within 6-8 weeks of daily use.
Can supplements actually improve memory?
Yes, several supplements have clinical evidence supporting memory improvements, particularly lion’s mane mushroom, phosphatidylserine, DHA omega-3, and ginkgo biloba. These supplements support memory through different mechanisms — NGF stimulation, cell membrane health, neurotransmitter production, and cerebral blood flow. Results are generally modest and most pronounced in people with existing nutrient deficiencies or mild cognitive impairment.
Is lion’s mane mushroom good for memory?
Lion’s mane is one of the most promising natural supplements for memory. It contains unique compounds (hericenones and erinacines) that stimulate nerve growth factor production — a protein essential for neuron growth, maintenance, and survival. Clinical trials in older adults with mild cognitive impairment showed significant improvements in cognitive function after 16 weeks of daily lion’s mane supplementation.
Are brain supplements safe for older adults?
Most brain supplements are safe for older adults at recommended doses. However, ginkgo biloba can interact with blood thinners and should be avoided before surgery. High-dose fish oil may also increase bleeding risk. B vitamins, lion’s mane, and phosphatidylserine have excellent safety profiles. Older adults should consult their physician before starting any new supplement, particularly if taking prescription medications.
What vitamins help with brain fog?
Brain fog often responds to B12 (supports nerve function and energy), iron (delivers oxygen to the brain), vitamin D (linked to cognitive function), and omega-3 DHA (maintains brain cell membranes). If brain fog is persistent, getting blood work to check for B12, iron, vitamin D, and thyroid function is recommended before supplementing, as these are the most common nutritional causes.