Alpha-GPC (alpha-glycerylphosphorylcholine) is one of the most bioavailable forms of choline available, supporting cognitive function, memory, and physical performance by boosting acetylcholine production in the brain. Whether you are looking for mental clarity, athletic performance, or neuroprotective support, here are the best alpha-GPC supplements on the market.
Quick Comparison
Product
Dose per Serving
Form
Best For
Rating
Alpha GPC with BioPerine
600 mg
Capsules
Best Overall
4.5/5
Toniiq Ultra High Purity Alpha GPC
600 mg (90%+ purity)
Capsules
Best Purity
4.6/5
Momentous Alpha GPC
300 mg
Capsules
Best for Athletes
4.5/5
Double Wood Alpha GPC
600 mg
Capsules
Best Value
4.4/5
Nutricost Alpha GPC
600 mg
Capsules
Best Budget Pick
4.4/5
Horbäach Alpha GPC
600 mg
Capsules
Best 120-Count Value
4.3/5
NOW Alpha GPC
300 mg
Veg Capsules
Most Trusted Brand
4.4/5
1. Alpha GPC Supplement with BioPerine – Best Overall
Alpha GPC Supplement & BioPerine for Hyper Absorption – 120 Count, Alpha-GPC 600mg per Serving – Nootropics for Memory, Focus, Energy, & Drive – Choline Supplements to Boost Acetylcholine, Made in USA
Boost Memory and Focus: Hyper Absorb Alpha GPC by RevSci enhances memory and focus, making it one of the strongest brain supplements for memory and focus; Experience a dynamic brain boost and improve cognitive function with this powerful nootropic
Enhanced Absorption with BioPerine: Our Alpha GPC formula includes BioPerine for hyper absorption, ensuring your body fully absorbs this choline supplement. Enjoy the benefits of a nootropics brain support supplement designed for maximum bioavailability and effectiveness
Support Physical & Mental Performance: Alpha-GPC supports the natural production of human growth hormone (HGH), enhancing strength, stamina, and recovery; Perfect for athletes and anyone seeking a memory supplement for brain and body performance
Promotes Cognitive Health & Brain Clarity: Supports overall brain health by enhancing acetylcholine levels, improving mental clarity, and reducing brain fog; Ideal for maintaining youthful cognitive function
Scientifically Backed & USA Made – RevSci Alpha GPC supplement is made with research-backed ingredients in a cGMP-certified facility in the USA. This brain supplement is crafted to the highest standards of quality and effectiveness, ensuring it is one of the strongst brain focus and memory supplements.
This alpha-GPC formula pairs a full 600 mg dose with BioPerine black pepper extract for enhanced absorption—a combination most competitors lack.
Delivering 600 mg of alpha-GPC per serving across 120 capsules, this supplement stands out by including BioPerine (piperine), which clinical research has shown can increase the bioavailability of supplemented nutrients by up to 30%. The formula targets memory, focus, energy, and drive by boosting acetylcholine production. Each batch is manufactured in the USA and designed for both cognitive and athletic performance support.
Pros:
BioPerine inclusion significantly boosts absorption
120-count bottle provides excellent supply
Effective 600 mg clinical dose
Cons:
Two capsules per serving
Contains black pepper—may not suit those with GI sensitivities
Best for: Anyone wanting maximum absorption from their alpha-GPC supplement
2. Toniiq Ultra High Purity Alpha GPC – Best Purity
Toniiq Ultra High Purity Alpha GPC Capsules – 600mg Concentrated Formula – 90%+ Highly Purified and Bioavailable Nootropic – 120 Capsules Alpha GPC Supplement
The Highly Purified Form of Alpha GPC – Toniiq Alpha GPC capsules contain 600mg of the highest quality Alpha GPC in each serving. Our Alpha-GPC contains an unprecedented purity level of 90%+ (most alpha gpc and choline products contain less than 50%).
Highly Purified and Bioavailable – Alpha GPC has amazing health benefits, but purity and absorption have always been a major challenge; something most other Alpha GPC powder, Alpha GPC 300mg and Alpha GPC 600mg supplements don’t provide as it requires an extra step (and expense) in the manufacturing process. At 90%+ standardization, Toniiq Alpha GPC provides some of the purest, most potent Alpha GPC available.
Setting a New Standard for Purity – To ensure that you are getting the highest-quality product, each batch is tested for quality and purity both during and after manufacturing.
Quality, First, and Foremost – Toniiq products are produced in a GMP-certified, state-of-the-art manufacturing facility right here in the USA.
Each Batch is Individually Tested – We test each batch both ourselves and through a third-party independent laboratory to ensure our ingredients contain the correct standardized level of purity and active ingredients. We also test each batch for any possible additives, contaminants, and impurities to ensure the highest level of quality.
Toniiq sets the purity standard at 90%+ standardization—far above the sub-50% found in most alpha-GPC products on the market.
Each serving delivers 600 mg of alpha-GPC at an industry-leading 90%+ purity level, meaning you get significantly more active compound per capsule than standard formulations. The 120-capsule bottle provides a 60-day supply. Every batch undergoes Toniiq’s TQ 5-Point Testing Program, which includes screening for heavy metals, microbiology, active ingredient accuracy, and other impurities. The product is manufactured in GMP-certified facilities in the USA and is gluten-free, non-GMO, and vegan.
Pros:
Industry-leading 90%+ purity standardization
Rigorous 5-point third-party testing protocol
Vegan, gluten-free, and non-GMO
Cons:
Premium pricing reflects higher purity
Two capsules per serving
Best for: Users who prioritize maximum purity and potency in their choline supplementation
3. Momentous Alpha GPC – Best for Athletes
Momentous Alpha GPC Supplement – Cognitive Health & Function Support – NSF Certified for Sport – GMO- & Gluten-Free – 60 Servings
Improve Muscle Function – Our Alpha GPC cognitive supplement supports the natural production of acetyl choline for better muscle function, & in athletes prevents exercise-induced reductions in choline levels to help endurance & growth hormone secretion.
Support Cognitive Development – This supplement promotes cognitive development by increasing levels of acetylcholine, a key neurotransmitter involved in memory & learning. It supports mental clarity & cognitive performance.
Enhance Mental Clarity – Alpha GPC contributes to better focus & mental sharpness. It enhances neuronal communication, which is crucial for maintaining mental agility & cognitive health.
Maximize Use – For optimal benefits, take 300-600 mg per day earlier in the day, as tolerated. This dosage helps support muscle function & cognitive development effectively.
Crafted by Experts – We work with some of the greatest minds in science & athletic performance who tap into the latest research & real-world experience to design products with 1 common goal – to help you be your best.
The only alpha-GPC supplement on this list with NSF Certified for Sport status, making it the clear choice for competitive athletes subject to drug testing.
Momentous Alpha GPC delivers 300 mg per capsule (recommended dosage of 300-600 mg daily), designed to support both cognitive function and athletic performance. The supplement is part of the Dr. Andrew Huberman-recommended protocol and supports acetylcholine production, which is critical for muscle contraction and endurance. NSF Certified for Sport means every batch is tested for over 270 banned substances. The formula is also GMO-free and gluten-free. The 60-serving bottle provides one to two months of use depending on dosage.
Pros:
NSF Certified for Sport—verified free of banned substances
Flexible dosing at 300 mg per capsule
Backed by Huberman Lab protocol recommendations
Cons:
Higher cost per serving than most alternatives
300 mg per capsule means two needed for standard 600 mg dose
Best for: Athletes, especially those subject to anti-doping testing, who need verified-clean supplementation
4. Double Wood Alpha GPC – Best Value
Alpha GPC Choline Brain Supplement for Acetylcholine (60 Count, 600mg Servings) Advanced Memory Formula, Focus and Brain Support, Focus Supplement (Manufactured in The USA) by Double Wood
POWERFUL BIOAVAILABLE CHOLINE SUPPORT: Alpha GPC is the most bioavailable form of Choline currently available. Choline is a water-soluble nutrient which acts as a precursor to the neurotransmitter Acetylcholine, making Double Wood’s Alpha GPC Choline Capsules easily absorbed by the body and fast-acting
ADVANCED MEMORY FORMULA: Double Wood Supplements’ Alpha GPC Choline may help support cognitive function, including memory, learning and focus
SUPPORTS ACETYLCHOLINE LEVELS: Our Alpha GPC is a precursor to the neurotransmitter Acetylcholine, which supports memory and brain function. Alpha GPC brain pills may help support brain health, especially as one ages
ROOTED IN QUALITY: Manufactured and Tested in the USA from Globally Sourced Ingredients. Double Wood’s Alpha GPC is manufactured and tested for microbes and heavy metals right here in the USA from Globally Sourced Ingredients
WE BOTTLE WELLNESS: At Double Wood we provide pure, potent supplements that deliver exceptional value, all backed by careful sourcing and rigorous third-party testing
Double Wood delivers a straightforward, high-potency alpha-GPC at one of the most competitive prices in the category.
Each bottle contains 60 capsules delivering 600 mg of alpha-GPC per two-capsule serving (300 mg per capsule at 50% potency). Double Wood is a well-established nootropics brand based in Philadelphia with a strong reputation for consistent quality. The product is manufactured and third-party tested in the USA for both heavy metals and microbial contamination. The formula is non-GMO and gluten-free, keeping the ingredient list clean and simple with no unnecessary fillers.
Pros:
Excellent price-to-quality ratio
Third-party tested for heavy metals and microbes
Established nootropics brand with strong reviews
Cons:
Only 30 servings per bottle at the 600 mg dose
Standard 50% potency—lower than Toniiq’s 90%+
Best for: First-time alpha-GPC users looking for a reliable, affordable option from a trusted brand
5. Nutricost Alpha GPC – Best Budget Pick
Nutricost Alpha GPC 600mg, 120 Vegetarian Capsules – Non-GMO and Gluten Free, 300mg Per Capsule
300mg Per Capsule of High Quality Alpha GPC (Glycerophosphocholine)
120 Vegetarian Capsules of Alpha GPC Per Bottle
Third Party Tested, Soy Free, Gluten Free, and Non-GMO
Rich in Choline, Vegetarian Friendly
Made in a NSF Certified, GMP Compliant, FDA Registered Facility
Nutricost offers one of the best per-serving values for alpha-GPC with a clean, no-frills formula in a generous 120-capsule bottle.
Each bottle provides 120 vegetarian capsules with 300 mg of alpha-GPC per capsule (600 mg per two-capsule serving), delivering 60 full servings. Nutricost manufactures all products in a GMP-compliant, FDA-registered facility, and every batch is tested by independent, ISO-accredited laboratories. The formula is non-GMO and gluten-free with minimal fillers—just rice flour, cellulose capsule, stearic acid, magnesium stearate, and silica. The straightforward formulation keeps costs low without sacrificing quality.
Pros:
120 capsules per bottle for outstanding value
ISO-accredited third-party lab testing
Clean, minimal ingredient list
Cons:
Standard 50% potency
Contains rice flour as a filler
Best for: Cost-conscious buyers who want a reliable, well-tested alpha-GPC at the lowest price per serving
6. Horbäach Alpha GPC – Best 120-Count Value
Sale
Horbäach Alpha GPC 600mg | 120 Capsules | Vegetarian, Non-GMO & Gluten Free Choline Supplement | Supports Healthy Memory, Focus and Clarity
ALPHA GPC: A bioavailable form of choline that is used to support normal cognitive function*
ADVANCED FORMULA: Provides 600mg per serving of this beneficial compound in vegetarian capsules
EXPERTLY CRAFTED: Our professional formula is backed by our commitment to purity and potency
HORBAACH MANUFACTURERS: Laboratory Tested, Trusted Ingredients, Superior Quality, 100% Guaranteed!
NATURALLY FREE OF: Gluten, Wheat, Yeast, Milk, Lactose, Artificial Flavor & Artificial Sweetener
Horbäach brings over 40 years of supplement expertise to a well-formulated, high-count alpha-GPC offering.
This 120-capsule bottle delivers 600 mg of alpha-GPC per two-capsule serving, providing 60 servings at a competitive price point. Horbäach has been in the natural products industry for over four decades, and their alpha-GPC is manufactured with the same quality standards they apply across their extensive supplement line. The formula is non-GMO, gluten-free, and soy-free, with vegetarian capsules. The scientifically designed formulation aims to provide the most bioavailable source of choline available.
Pros:
Backed by 40+ years of supplement manufacturing experience
120 capsules for a two-month supply
Non-GMO, gluten-free, soy-free
Cons:
Contains rice powder and dicalcium phosphate as fillers
Less specialized than nootropic-focused brands
Best for: Users who prefer supplements from established, long-running health brands
7. NOW Alpha GPC – Most Trusted Brand
Sale
Green Coffee Bean Extract for Uric Acid Cleanse & Detox – Green Coffee Beans with Turmeric, Tart Cherry & Celery Seed for Adults – Daily Uric Acid Flush for Joints Support & Kidney Cleanser – 90 Ct
ADVANCED URIC ACID CLEANSE & JOINT SUPPORT – Designed to help flush excess uric acid, support joint comfort, and promote kidney health, this powerful daily detox kidney support supplement with green coffee beans is ideal for men and women looking for natural help and balance.
PROMOTES HEALTHY URIC ACID LEVELS & MOTION – Our uric acid support formula with green coffee extract helps maintain healthy uric acid levels, easing discomfort in joints, hands, feet, and muscles. This uric acid supplement also supports kidney function for optimal detox.
PREMIUM HERBAL BLEND FOR MAXIMUM EFFECTIVENESS – Featuring Turmeric, Tart Cherry, Green Coffee Extract, Celery Seed, Chanca Piedra, Quercetin, Bromelain, Vitamin B6 & Citric Acid, these potent ingredients work together to support immune balance, healthy circulation, and kidney detox & health.
HOW TO USE & IMPORTANT WARNINGS – Take two capsules of our kidney health supplement with green coffee bean powder daily with food or as directed by your healthcare provider. Consult your doctor before use if you have kidney disease, are on medication, are pregnant, or nursing.
MADE WITH GLOBALLY SOURCED INGREDIENTS – Our supplements with green coffee extract powder for men & women are manufactured in a GMP-compliant facility & non-GMO. This third-party tested formula provides purity, potency & safety, delivering a relief for uric acid and healthy joints.
NOW Foods applies its rigorous quality standards to a clean, vegan-friendly alpha-GPC formula with 300 mg per capsule.
NOW’s Alpha GPC provides 300 mg of bioavailable choline per vegetarian capsule, making it easy to customize dosing from 300-600 mg daily. As one of the most recognized names in dietary supplements, NOW brings GMP-certified manufacturing, extensive third-party testing, and decades of quality assurance to every product. The formula is vegan, non-GMO, and free from common allergens. The 60-count bottle provides one to two months of supply depending on dosing preferences. NOW’s family-owned operation has been producing quality supplements since 1968.
Pros:
One of the most trusted supplement brands globally
Flexible 300 mg per capsule dosing
Vegan-friendly with clean ingredient profile
Cons:
Lower dose per capsule means more capsules for full 600 mg serving
60-count bottle runs out faster at higher doses
Best for: Anyone who prioritizes buying from an established, family-owned supplement brand with proven quality standards
8. Sports Research Alpha GPC – Best Liquid Capsule
Nutricost Alpha GPC 600mg, 60 Vegetarian Capsules – Non-GMO and Gluten Free, 300mg Per Capsule
300mg Per Capsule of High Quality Alpha GPC (Glycerophosphocholine)
60 Vegetarian Capsules of Alpha GPC Per Bottle
30 Servings of Alpha GPC Per Bottle
Third Party Tested, Vegetarian Friendly, Gluten Free, Soy Free, and Non-GMO
Made in a GMP Compliant, FDA Registered Facility
Sports Research delivers alpha-GPC in a liquid softgel format for potentially faster absorption and easier swallowing.
Offering 630 mg of alpha-GPC per serving in a liquid capsule format, Sports Research provides a slightly higher dose than most standard 600 mg products. The liquid capsule design may offer improved absorption compared to traditional powder-filled capsules. The product is Vegan Certified, non-GMO verified, and gluten-free. Sports Research has built a solid reputation in the supplement space, particularly with athletes and active individuals. Available in both 60-count and 120-count bottles.
Pros:
Liquid capsule format for potentially better absorption
Slightly higher 630 mg dose per serving
Vegan Certified and non-GMO verified
Cons:
Liquid capsules are larger than standard capsules
Premium pricing for the liquid delivery format
Best for: Users who prefer liquid capsule delivery for faster absorption
How to Choose the Best Alpha-GPC Supplement
The standard effective dose of alpha-GPC for cognitive support is 300-600 mg per day, while studies on athletic performance have used 300-600 mg taken 30-60 minutes before exercise. For cognitive decline, research has used up to 1,200 mg daily divided into three 400 mg doses. Most quality supplements provide 600 mg per serving, which covers the effective range for general brain health and performance.
Purity is a critical factor that varies widely across products. Standard alpha-GPC supplements contain 50% active compound, meaning a 600 mg capsule delivers about 300 mg of actual alpha-GPC. Premium products like Toniiq offer 90%+ purity, providing significantly more active compound per milligram. Check the label for standardization percentages when comparing products.
Capsules dominate the alpha-GPC market, though powder forms are available for those who prefer mixing into beverages. Be aware that alpha-GPC powder is highly hygroscopic—it absorbs moisture from the air and can turn into a gel-like substance if not stored properly in airtight containers. For most users, capsules are the more convenient and stable choice.
Third-party testing and GMP certification should be non-negotiable. Look for products tested by independent laboratories for heavy metals, microbes, and active ingredient verification. Athletes subject to drug testing should specifically look for NSF Certified for Sport products like Momentous to ensure their supplement is free of banned substances.
Frequently Asked Questions
What is alpha-GPC and how does it work?
Alpha-GPC is a highly bioavailable form of choline that crosses the blood-brain barrier efficiently. Once in the brain, it serves as a precursor to acetylcholine—a neurotransmitter critical for memory formation, learning, focus, and muscle contraction. It occurs naturally in small amounts in foods like eggs, fish, meat, and dairy, but supplementation provides much higher concentrations for targeted cognitive and performance support.
How much alpha-GPC should I take daily?
For general cognitive support, 300-600 mg daily is the most commonly studied and recommended range. For athletic performance, 300-600 mg taken 30-60 minutes before exercise has shown benefits in power output and growth hormone response. For cognitive decline, clinical research has used 1,200 mg daily divided into three doses of 400 mg. Start with a lower dose and adjust based on your response.
When is the best time to take alpha-GPC?
For cognitive benefits, take alpha-GPC in the morning or early afternoon with food—this aligns with the brain’s peak acetylcholine demand periods. For athletic performance, take it 30-60 minutes before training. Avoid taking it late in the evening, as increased acetylcholine activity may interfere with sleep in some individuals.
Are there side effects of alpha-GPC?
Alpha-GPC is generally well tolerated at standard doses. Potential side effects at higher doses include headaches, dizziness, heartburn, insomnia, and skin rash. Headaches are the most commonly reported side effect and may indicate the dose is too high. Starting with 300 mg and gradually increasing can help minimize any initial side effects.
Can I stack alpha-GPC with other nootropics?
Yes, alpha-GPC is one of the most popular stacking nootropics. It pairs well with racetams (which increase acetylcholine demand), lion’s mane mushroom (which supports nerve growth factor), caffeine and L-theanine (for focused energy), and huperzine A (which prevents acetylcholine breakdown). The choline support from alpha-GPC often enhances the effects of other cognitive supplements.
How long does it take for alpha-GPC to work?
Many users report noticeable effects on focus and mental clarity within 30-60 minutes of taking alpha-GPC, making it one of the faster-acting nootropics. Physical performance benefits are also relatively quick, which is why pre-workout timing is effective. Long-term neuroprotective benefits build over weeks to months of consistent use.