Saffron extract is one of the most promising natural ingredients for mood support, backed by multiple clinical trials showing benefits comparable to conventional mood-enhancing options. The key is choosing a supplement with a clinically relevant dose of genuine saffron extract. Here are the top saffron-based mood supplements worth considering.
Quick Comparison
Product
Key Ingredient
Form
Best For
Rating
Effective Nutra Saffron Gummies
Saffron + Vitamin D2 + Passion Flower
Gummies
Overall Best
4.5/5
Luma Nutrition Saffron Extract
Saffron Extract 88.5mg
Capsules
Best Pure Extract
4.4/5
Saffron Supplements Gummies 100mg
Saffron + Magnesium + L-Theanine
Gummies
Best Calming Stack
4.3/5
Saffron Gummies for Kids & Adults
Saffron 88.5mg + Magnesium 300mg
Gummies
Best for Families
4.3/5
Dorado Nutrition Saffron Capsules
Saffron Extract 88.5mg
Capsules
Best USA Made
4.3/5
SOLARAY Affron® Saffron Extract
Affron® Saffron (Lepticrosalides®)
VegCaps
Best Clinically Proven
4.5/5
Nutricost Saffron Extract
Saffron Extract 88.5mg
Capsules
Best Value
4.4/5
1. Effective Nutra Saffron Gummies – Best Overall
Effective Nutra Saffron Gummies | Sugar-Free Supplement with Vitamin D2, Passion Flower, St. John’s Wort & GABA | Positive Mood, Digestion, Energy | Natural Berry Flavor, Made in USA (90 Count)
#1 ULTIMATE SAFFRON GUMMY: Not a fan of swallowing large capsules? Our sugar free saffron gummies taste good & go down easy. 90 Gummies in a bottle for the best value out there!*
GET ALL THE BENEFITS: Our saffron supplement is packed with a 5-in-1 blend that may promote positive mood and attitude, digestion, physical fitness, increase in energy and focus, stress relief, heart health and brain function.*
SUPPORTS HEALTHY MOOD: Saffron extract has a long history of traditional use for supporting a healthy mood and promoting emotional balance. A great way to maintain a positive attitude and mood all day long!*
HEALTHY & DELICIOUS: Yes, we did it! At Effective Nutra we want to provide a healthy and enjoyable experience. Our saffron gummies are naturally berry flavored. With no artificial colors or flavors, you can be sure you’re getting the most nourishing health gummies out there!*
EFFECTIVE NUTRA’S SEAL OF EXCELLENCE: QUALITY YOU CAN TRUST: Our supplements are Vegan, Gluten-Free, Non-GMO, Third Party Tested, GMP Certified and proudly Made in USA with Globally Sourced Ingredients. That’s the Effective Nutra seal of excellence!*
A sugar-free saffron gummy combining saffron extract with vitamin D2 and passion flower for multi-pathway mood support.
Effective Nutra’s saffron gummies stand out by combining three mood-supporting ingredients in one chewable supplement. Saffron extract works on serotonin pathways, vitamin D2 addresses a common nutritional deficiency linked to low mood, and passion flower promotes GABA activity for natural relaxation. The sugar-free formulation avoids the blood sugar spikes that can worsen mood instability. Manufactured in a GMP-certified facility with quality ingredients, this is the most well-rounded saffron gummy available.
Pros:
Three mood-supporting ingredients in one gummy
Sugar-free — avoids mood-disrupting blood sugar spikes
Convenient gummy format with good taste
Cons:
D2 form of vitamin D is less efficiently used than D3
Individual saffron dose may be lower than capsule alternatives
Best for: People who want a tasty, comprehensive mood gummy built around saffron
2. Luma Nutrition Saffron Extract – Best Pure Saffron Capsule
Luma Nutrition Saffron Extract Capsules – Premium Saffron Supplements – 88.50 mg Pure Saffron Pills – Mood Support – Eye Support – Made in The USA – 60 Capsules
Potent & Effective – Elevate Health Naturally: Unleash the power of our natural saffron extract, a top-tier supplement for improved macular eye health, mood enhancer, brain support and energy support. Elevate your wellness journey with proven efficacy.
Many Health Benefits: Our optimized saffron powder is used by many as an effective eye supplement for both men and women. It may also help support overall metabolic function for healthy weight management.
Mood Boosting Marvel – Elevate Positivity: Transform your mood with Luma Nutrition saffron pills, a renowned mood support supplement. Embrace a natural mood boosting that promotes serotonin and positive energy support without the added sugar of Saffron gummies.
Easy 1-Month Supply: Create a solid daily routine with Luma’s 30-day supply of premium saffron supplements for kids and adults. Makes the perfect monthly subscription! Always stay in stock and save money at the same time!
USA-Made Excellence – Veteran Owned: Trust Luma Nutrition’s saffron capsules, crafted in GMP certified US facilities. We’re family-owned, committed to quality, and here to support your well-being journey.
A focused 88.5mg saffron extract capsule delivering the clinically studied dose with no unnecessary additions.
Luma Nutrition keeps it simple with 88.5mg of pure saffron extract per capsule — the exact dose used in most clinical mood studies. This no-frills approach appeals to supplement users who want precise dosing without proprietary blends or filler ingredients. The formula is designed specifically for mood and emotional well-being, and the capsule format ensures consistent delivery of the active saffron compounds crocin and safranal. Well-reviewed by thousands of customers for mood support.
Pros:
88.5mg clinically studied dose — precisely what research supports
Pure saffron extract with no unnecessary additives
Strong customer review track record
Cons:
Capsule only — no gummy or liquid option
Lacks complementary mood ingredients
Best for: Minimalists who want a clean, clinically dosed saffron capsule and nothing more
3. Saffron Supplements Gummies 100mg with Magnesium Glycinate & L-Theanine – Best Calming Stack
Saffron Supplements Gummies 100mg – 100% Pure Saffron Extract with Magnesium Glycinate, L-Theanine, Turmeric, Ashwagandha, Honey & Vitamin B Complex for Mood & Power, Antioxidant, Vitality – 60 Count
Organic Saffron Extract for Maximum Purity & Potency >>> Our saffron supplements each serving delivers 100mg of 0.3% Safranal extract from 100% certified organic saffron silk grown in Spain. Unlike many brands that use blends, or lower-grade saffron, we use only authentic Spanish saffron for reliable results. Specially designed for those seeking natural mood balance, focus, energy well-being.
Mood & Energy Support >>> Known as the “happy spice,” saffron has long been celebrated for its uplifting effects and ability to brighten the brain. Each saffron gummy paired with a synergistic blend of magnesium glycinate, ashwagandha, L-theanine & rhodiola rosea. This unique formula works to calm mood, keep natural energy & brain clarity—caffeine free. Whether you’re powering through a busy day or simply want a gentle lift in mood energy, our saffron offers a delicious way to feel your best.
LESS OF HUNGER, CLOSER TO GOALS >>> Surprisingly, saffron can support healthy eating habits, help keep your body healthy, provide energy support, making it more efficiently as the management gummies to help you eat healthy portions, reduce mood snacking frequency due to temporary bad mood, and consume less calories. In addition enriched with Vitamin C, D3, Folate, Vitamin B6, and Vitamin B12, they also help maintain immune strength and natural energy—keeping you balanced and motivated every day.
HEALTHY LIFESTYLE ON THE GO >>> Enjoy the power of saffron every day—without the hassle of capsules, pills, teas, or powders. Our convenient formula makes it easy to get your daily dose, wherever life takes you. Packed with the antioxidant-rich benefits of Saffron & Turmeric, our supplement helps support your overall wellness, including mood balance, eye health, antioxidant support and cellular protection. Take 1 gummy a day help keep you feeling and seeing your best.
UNMATCHED QUALITY & SUPPORT >>> Our gummies infused with Manuka Honey for added wellness, these gummies are a tasty, on-the-go alternative. All of our whole herb saffron extract gummies are manufactured, tested, and bottled in a 3rd-party tested facility for superior quality and consistency. Please contact us if you have any questions, we offer “always online” support and will take care of you.
A mood and relaxation gummy pairing 100mg saffron with magnesium glycinate and L-theanine for calm, balanced mood.
This gummy delivers 100mg of saffron extract — slightly above the standard clinical dose — alongside magnesium glycinate and L-theanine. The combination is strategic: saffron supports serotonin for positive mood, magnesium glycinate calms the nervous system, and L-theanine promotes relaxed focus without drowsiness. This three-ingredient approach makes it particularly effective for people who experience both low mood and anxiety, as it addresses the emotional and physical tension simultaneously.
Pros:
Saffron + magnesium + L-theanine is a synergistic mood stack
100mg saffron exceeds the clinical minimum
Addresses both mood and anxiety in one product
Cons:
Gummy format limits the magnesium dose compared to capsules
May cause mild drowsiness due to calming ingredients
Best for: Those dealing with both low mood and anxious feelings who want a single-product solution
4. Saffron Gummies for Kids & Adults with Magnesium Glycinate 300mg – Best Family Supplement
Sale
Saffron Gummies for Kids&Adults with Saffron 88.5mg + Magnesium Glycinate 300mg | Max Strength Saffron Supplements with St. John’s Wort, L-Theanine, Rhodiola , Rosemary – Supports Mood & Focus
Ultra-High Content–Our saffron supplements leverage cutting-edge herbal extraction technology. Each serving saffron gummy delivers 88.5 mg of premium saffron extract, standardized to 0.5% Safranal. This high-quality saffron extract in our saffron supplements is chosen to provide noticeable mood and cognitive benefits.
Proprietary Mental Clarity & Calm Blend– Our saffron gummies supplement include an exclusive mix of St. John’s Wort, L-Theanine, Rhodiola, Rosemary, and Passion Flower extracts. This potent blend in our saffron supplements is formulated to foster mental clarity and relaxation, helping you navigate daily challenges with ease.
Superior Absorption and Bioavailability–Our saffron extract gummies are made using cutting-edge 10:1 extraction technology for rapid absorption and efficacy. The premium formula is designed for relaxation and a calm mood.Perfect for maintaining a positive outlook and sharp focus throughout your busy day.
Powerful Antioxidant Support–Each serving saffron gummy is packed with 300mg of highly bioavailable Magnesium Glycinate. Saffron extract and magnesium glycinate are crafted for relaxation and restful sleep. Additionally, our saffron supplements include essential vitamins B6, B12, D3, and Zinc to aid in melatonin synthesis, offering a melatonin-free option for regulating circadian rhythm, ensuring restful sleep and refreshed mornings without grogginess.
Premium, Trusted Quality & Purity– We are committed to pure and effective ingredients. Non-GMO, gluten-free, and gelatin-free. Produced in a GMP-certified facility, every batch is crafted to meet our high standards for quality and safety. Each bottle contains a convenient 30-day supply.
A family-friendly saffron and magnesium gummy with 88.5mg saffron and 300mg magnesium glycinate per serving.
This versatile formula is designed for the whole family, combining saffron at the standard 88.5mg clinical dose with a substantial 300mg of magnesium glycinate. Magnesium deficiency is extremely common and directly impacts mood, sleep, and stress response — pairing it with saffron creates a powerful daily mood supplement. The gummy format ensures compliance for kids and adults alike, and the magnesium glycinate form is one of the gentlest on the stomach.
Pros:
300mg magnesium glycinate — a therapeutically meaningful dose
Suitable for kids and adults
Two proven mood ingredients in one serving
Cons:
Check age-specific dosing recommendations on label for children
Contains added sugar typical of gummy supplements
Best for: Households where multiple family members need mood and stress support
5. Dorado Nutrition Saffron Extract 88.5mg – Best USA Made
Saffron Supplements for Mood, Energy & Vision Support (3 Month Supply) Pure Saffron Extract 88.5mg Per Serving – Vegan Safe, Gluten Free, Third Party Tested & Non GMO – USA Made (90 Veggie Capsules)
SAFFRON SUPPLEMENT CAPSULES – Each serving provides 88.5mg of saffron extract, offered in an easy capsule format. A simple way for adults to include saffron flower in their daily wellness routine.
MOOD, ENERGY & VISION SUPPORT – Saffron has long been valued for its traditional uses. Our saffron capsules are crafted to support focus, balance, and overall vitality, making them a versatile addition to your supplement stack.
EASY TO TAKE CAPSULES – No need for teas or powders. Our saffron capsules are convenient, tasteless, and provide a consistent serving size to fit seamlessly into your routine.
Manufactured in the USA from Globally Sourced Ingredients – Dorado Nutrition is proudly a 100% American owned company creating jobs & better futures for all our employees & stakeholders. All of our supplements are manufactured in the USA! Our Saffron Flower Extract Supplement capsules
MANUFACTURED IN A GMP CERTIFIED FACILITY – Our Saffron Flower Extract Supplement capsules are GMP compliant to ensure premium quality. Our supplements are always free from unnecessary additives or preservatives and are third-party independently tested.
A USA-manufactured saffron capsule delivering 88.5mg per serving from a 100% American-owned company.
Dorado Nutrition delivers 88.5mg of saffron extract in an easy-to-take capsule format, manufactured entirely in the USA. The formula is designed to support mood, energy, and vision — the three primary areas where saffron has shown clinical benefits. The company is 100% American-owned and manufactures in GMP-compliant facilities. The 90-capsule bottle provides a full three months of daily supplementation, making it a practical and patriotic choice for long-term mood support.
Pros:
100% USA-made by an American-owned company
Three-month supply per bottle
Standard 88.5mg clinical dose
Cons:
Newer brand with fewer reviews compared to established competitors
No patented saffron extract used
Best for: Buyers who prioritize USA manufacturing and American-owned brands
6. SOLARAY Saffron Extract with Affron® – Best Clinically Proven
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SOLARAY Saffron Extract – Sleep and Positive Mood Support – Vegan and Gluten Free Saffron Supplements – Lab Verified – 60-Day Guarantee – 30 Servings, 30 VegCaps
Mood Support Supplement – Made with clinically studied Affron (R) Saffron, a saffron extract that uses a proprietary process to ensure the highest quality, our Vital Extracts Saffron supplement is designed to help support a positive mood.*
Sweet Dreams – With powerful plant compounds, Saffron extract may help provide many health benefits including sleep support to help you start each day feeling revitalized.*
Powerfully Potent – Every 1-VegCap serving size is standardized to contain 1 mg or 3.5% Lepticrosalides (R), a key compound of saffron believed to be responsible for its beneficial properties.
Making a Difference – To reduce our carbon footprint, Solaray bottles are made from post-consumer recycled resin, helping keep plastic out of our landfills and oceans; we’ve also installed solar panels as an additional energy source at our Ogden, Utah facility—to power the processes and products that help you Live Brighter.
Trusted Brand – Vegan, gluten free, made in our GMP-certified facility, and always tested in our own state-of-the-art lab in Utah to bring you the best possible quality.
Features the patented Affron® extract standardized to Lepticrosalides® — the most researched form of saffron for mood.
SOLARAY’s saffron supplement uses Affron®, a proprietary saffron extract that has been the subject of multiple randomized, double-blind clinical trials for mood support. Each VegCap is standardized to contain 3.5% Lepticrosalides® — the specific bioactive compounds in saffron responsible for its mood-enhancing effects. SOLARAY tests every batch in their own state-of-the-art lab in Utah and manufactures in a GMP-certified facility. The Affron® extract also shows promise for sleep quality support, adding a secondary benefit for mood recovery.
Pros:
Affron® is the most clinically validated saffron extract globally
Standardized to 3.5% Lepticrosalides® for guaranteed efficacy
In-house lab testing and GMP-certified production
Cons:
30-day supply only — smaller bottle
Higher per-serving cost due to patented ingredient
Best for: Evidence-driven consumers who want the most scientifically backed saffron extract
7. Pure Micronutrients Saffron Extract – Best NSF Certified
Saffron Supplements – 100% Pure Saffron Extract Capsules – Boost Energy & Mood, Support Eye & Heart Health
GOOD VIBES; BOOST ENERGY, ATTITUDE & MOOD – Rich in antioxidants, the ‘Sunshine Spice’ supports dopamine levels in the brain, protects brain cells against oxidative stress, which in turn supports memory & learning ability, energy levels and a healthy mood – the perfect supplement to sustain energy levels and a healthy outlook throughout the whole day!
SUPPORT METABOLISM – Pure Saffron is known to promote a healthy metabolism; calming indigestion, cramping, bloating and/or constipation.
SUPPORT HEART HEALTH – Known for its powerful antioxidant properties, Pure Saffron supports the heart. These rich antioxidants further support a stronger immune system by helping neutralize harmful free radicals – A vibrant little spice that packs a powerful punch!
EYE HEALTH – With high concentrations of Carotenoids, saffron supports optimal eye health and macular degeneration; supporting the structure and function of retinal cells by protecting the lens and retina light-sensitive cells from breakdown. Saffron supplementation can support by protecting the lens and retina from aging, promoting good eye health long-term
PURE, NATURAL & TRUSTED – Pure Saffron is natural, it contains no Magnesium Stearate, caffeine, GMOs, gluten, dairy, soy, preservatives, artificial colors or flavors. Made with Kosher & Halal ingredients. So you can reap the benefits without any of the Nasties. Practitioner Grade, USA Made, NSF Certified, Third Party Tested with a Satisfaction Guarantee.
An NSF-certified, practitioner-grade saffron supplement delivering 88.5mg per capsule with third-party verification.
Pure Micronutrients offers a practitioner-grade saffron extract at 88.5mg per capsule, NSF-certified and third-party tested. The formula is free from magnesium stearate, caffeine, GMOs, gluten, dairy, soy, preservatives, and artificial colors — one of the cleanest labels in the saffron category. Co-founded by a nutritionist, the brand emphasizes bioavailability and therapeutic dosing. The NSF certification provides an extra layer of quality assurance that most competitors don’t offer.
Pros:
NSF certified — rigorous independent quality verification
Practitioner-grade formulation with clean ingredients
Kosher and Halal certified
Cons:
Two capsules per day required (most competitors need only one)
Premium pricing
Best for: Health professionals and quality-focused consumers who demand NSF-certified supplements
8. Ultra6 Saffron Supplements by ZuvaLabs – Best for Mood & Vision
Ultra6 Saffron Supplements – 100% Pure Saffron Extract Capsules and Mood Enhancer for Women and Men – Natural Supplement for Eye Health (90 Servings)
BOOST YOUR MOOD: Feeling down? Our saffron extract capsules are here to lift your spirits. These saffron supplements boost mood and energy naturally, offering daily positivity and calm. Ideal for promoting a happier, balanced life.
SUPPORT YOUR EYES: Keep your eyes healthy with our saffron supplement. They help maintain clear vision and protect against eye strain, supporting better eye health and clarity, whether you’re spending long hours in front of screens or just want to keep your eyes sharp.
BETTER DIGESTION: Experience smooth digestion with our mood support supplement. These capsules reduce bloating, cramping, and constipation for a healthier digestive system. Enjoy improved digestion and fewer issues with regular use.
MADE IN THE USA: Trust the quality of our saffron capsules, made in a GMP-certified USA facility. Non-GMO and vegan, they ensure purity and safety in every capsule. Enjoy a premium, effective, and ethically produced energy support supplement.
CLEAN AND PURE: They’re 100% vegan and non-GMO, providing a natural and wholesome health option. Free from artificial additives and animal products, our capsules offer a clean, responsible choice for your wellness. Feel good about taking a clean, pure saffron supplement!
A dual-benefit saffron capsule at 88.5mg targeting both mood enhancement and long-term eye health.
Ultra6 (by ZuvaLabs) positions their saffron supplement as a dual-purpose product for both mood and eye health. The 88.5mg dose per capsule aligns with clinical research, and saffron’s high carotenoid content — particularly crocin — provides antioxidant support for retinal cells alongside its mood-enhancing effects. The 90-capsule bottle delivers a full three months of daily supplementation. The formula is clean and focused, with saffron as the sole active ingredient.
Pros:
Mood and vision support from a single ingredient
90 capsules — three-month supply
Well-reviewed with strong customer satisfaction
Cons:
No additional mood-supporting nutrients
Capsule form may not suit gummy preference
Best for: Adults wanting saffron’s mood benefits plus proactive eye health support
9. Nutricost Saffron Extract 88.5mg (240 Capsules) – Best Budget Pick
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The most cost-effective saffron supplement on the market with 240 capsules providing up to 8 months of mood support.
Nutricost delivers pure saffron extract at 88.5mg per capsule in a massive 240-count bottle. At just pennies per serving, this is far and away the best value for anyone committed to daily saffron supplementation. The formula is veggie-cap based, non-GMO, and gluten-free. Nutricost is a well-known brand in the supplement industry for offering no-nonsense formulations at aggressive prices. The 8-month supply eliminates the hassle of frequent reordering.
Pros:
240 capsules — up to 8 months in a single bottle
Unbeatable price per serving
Standard 88.5mg clinical dose with clean formula
Cons:
No-frills packaging and brand presentation
Single ingredient — no mood stack benefits
Best for: Value-oriented buyers who already know saffron works for them and want maximum supply per dollar
10. Pink Stork Cortisol Supplements for Women – Best for Stress-Related Mood
Pink Stork Cortisol Supplements for Women – Adaptogenic Adrenal Support & Hormone Balance with Organic Ashwagandha, Omega 3 DHA, Saffron, Multivitamins – Mood Support – 60 Count
Healthy Adrenal Function: Pink Stork ‘s Cortisol Complex is designed for women who are tired of feeling stressed or burnt out. Support healthy adrenal gland function with just 2 easy-to-swallow capsules daily. Non-drowsy formula, suitable for daytime use.
Consistency is Key: For best results, take 2 capsules daily with food or whenever it fits your wellness ritual. Whether at home or on the go, can be taken on an empty stomach if preferred, but consistency for 90 days supports the best results.
Holistic Support: This adrenal complex features Organic Ashwagandha, Omega-3 DHA, and Saffron. Enhanced with Vitamin D, B12, and Folate for cortisol support. Perfect for hormone harmony from PMS to menopause. Pair with other Pink Stork products like Cortisol Probiotic or Hormone Balance Multi for comprehensive wellness.
Trusted Quality: Third-party tested for purity. Gluten-free, dairy-free, and non-GMO. Breastfeeding-friendly and berry scented for a pleasant experience. No refrigeration needed, making it perfect for busy women.
Women-Owned & Run: Founded by Amy Suzanne, Pink Stork empowers women with scientifically backed cortisol support. Designed to fit your wellness journey, our products are expert-formulated for adrenal health. Join a community that supports your hormone balance.
An adaptogenic blend featuring saffron alongside ashwagandha and other botanicals for women’s cortisol and mood management.
Pink Stork takes a cortisol-first approach to mood support, incorporating saffron into an adaptogenic formula with ashwagandha and other organic botanicals. High cortisol is a primary driver of mood disruption in women, and this formula targets cortisol regulation to improve mood, energy, and hormonal balance simultaneously. The adaptogenic ingredients work together to build stress resilience over time. Designed specifically for women’s biochemistry and hormonal patterns.
Pros:
Addresses the cortisol-mood connection directly
Saffron + ashwagandha is a clinically supported combination
Formulated specifically for women’s needs
Cons:
Individual saffron dose may be lower within the blend
Not suitable for men or general-use scenarios
Best for: Women experiencing mood changes driven by high cortisol and chronic stress
How to Choose the Best Saffron for Mood Supplement
Look for supplements that deliver 88.5mg of saffron extract per serving — this is the dose supported by the most clinical evidence for mood benefits. Products using patented extracts like Affron® offer additional assurance of quality and standardized bioactive content, though they come at a higher price point.
Saffron quality varies significantly between products. Since saffron is the world’s most expensive spice by weight, cheaper supplements may contain adulterated or low-potency extracts. Third-party testing, NSF certification, and GMP manufacturing are reliable indicators that the saffron content is genuine and accurately labeled.
Decide whether you want a pure saffron supplement or a combination formula. Pure saffron capsules (88.5mg) are ideal for people who want to control their exact dosage. Combination products with magnesium glycinate, L-theanine, or vitamin D address mood from multiple angles but may deliver lower saffron doses per serving.
Consider the format that supports your daily consistency. Capsules deliver the most precise and potent doses, while gummies are easier to take and more enjoyable. Liquid drops offer the fastest absorption. The best supplement is the one you’ll take every single day, since saffron’s mood benefits depend on consistent use over 4-8 weeks.
Frequently Asked Questions
What is saffron and why is it used for mood support?
Saffron is a spice harvested from the stigma of the Crocus sativus flower. Its active compounds — primarily crocin, safranal, and crocetin — have been shown in multiple clinical trials to support serotonin metabolism in the brain, promoting positive mood and emotional balance. It has been used in traditional Persian medicine for centuries and is now one of the most clinically studied natural mood ingredients.
How much saffron should I take daily for mood?
Clinical studies consistently use 88.5mg of saffron extract per day, usually taken as one or two doses. Some products offer 100mg per serving with similar safety profiles. Doses above 200mg daily are not recommended due to potential side effects. The 88.5mg dosage has shown meaningful mood improvements in multiple peer-reviewed trials.
When should I take saffron supplements?
Saffron can be taken morning or evening, with or without food. Morning dosing may support a positive mood throughout the day, while evening dosing may benefit sleep quality if using a formula like Affron® that has sleep-supporting properties. What matters most is taking it at the same time daily for consistent blood levels.
Are there side effects of taking saffron for mood?
At the standard 88.5mg daily dose, side effects are rare and mild. Some users report dry mouth, drowsiness, or mild digestive upset during the first week. Saffron should be avoided during pregnancy in supplement doses and should not be combined with prescription antidepressants without medical guidance, as both affect serotonin pathways.
Can saffron be taken with antidepressants?
Saffron affects serotonin levels similarly to some antidepressant medications (SSRIs). Combining saffron with prescription antidepressants without medical supervision could theoretically lead to excessive serotonin activity. Always consult a healthcare provider before adding saffron supplements to an existing medication regimen for mood or mental health.
How long before saffron starts working for mood?
Most people notice improvements within 2-4 weeks of consistent daily use, with full benefits typically emerging by 6-8 weeks. Clinical trials evaluating saffron for mood typically run 6-12 weeks. Saffron is not a fast-acting supplement — it works through gradual modulation of neurotransmitter pathways and requires patience and consistency.